Results 271 to 280 of about 129,913 (308)

Neutrophil membrane-camouflaged SiRNA nanoplatform targeting IL-33 attenuates osteoarthritis through autophagy-dependent senescence regulation. [PDF]

J Nanobiotechnology
Fu Z, Chen J, Sun D, Zhang S, Chen J.
europepmc   +1 more source

Chondrocyte‐Targeted Nanoparticles Loaded with N‐Acetylcysteine Protect Articular Cartilage and Attenuate Osteoarthritis by Inhibiting Ferroptosis via Glutathione Maintenance

Small Science, EarlyView.
Chondrocyte‐targeted CS‐NAC nanoparticles restore redox balance, inhibit ferroptosis, and protect cartilage under mechanical stress. This nanoplatform enhances joint retention, elevates GPX4 activity, and attenuates osteoarthritis progression, offering a promising disease‐modifying therapeutic strategy.
Shaoyi Wang, Fujian Zhang, Xiaocong Zhou, Jie Yang, Zhe Li, Songlin Li, Qunshan Lu, Houyi Sun, Peilai Liu   +8 more
wiley   +1 more source

Activating Endogenous Condylar Stem Cells to Enhance TMJ Repair. [PDF]

J Dent Res
Tuwatnawanit T, Anthwal N, Tucker AS.
europepmc   +1 more source

Role of Pyroptosis in the Pathogenesis of Osteoarthritis: An Updated Review. [PDF]

J Inflamm Res
Yang F, Li D, Long W, Li E, Wei B.
europepmc   +1 more source

Integration of Network Pharmacology, Molecular Docking, and Experimental Validation to Identify the Effect of EGCG on Alleviating Chondrocyte Inflammatory Damage by Targeting ER Stress-STAT3 Crosstalk. [PDF]

J Inflamm Res
Zhao MJ, Yin JL, Luo JH, Ge YS, Huang CM, Meng TT, Wang XZ, Huang XH, Chen LL, Zhai YQ, Wu XB, Ding DF.   +11 more
europepmc   +1 more source

Three-dimensional human mucopolysaccharidosis IVA chondrocyte culture reveals significant impairments in the lysosomal-mitochondrial crosstalk. [PDF]

Sci Rep
Leal AF, Saikia S, Khan SA, Tomatsu S.
europepmc   +1 more source

Conjoint analysis of single-cell sequencing and high-throughput virtual screening regarding DDR2 in osteoarthritis disease models. [PDF]

Eur J Med Res
Mei H, Wang J, Zheng X, Yan R, Li W, Wang P, Wang X, Liu L.   +7 more
europepmc   +1 more source

Microenvironmental response-based treatment of osteoarthritis is a highly effective and durable program: a review. [PDF]

J Orthop Surg Res
Meng Y, Wu S, Liu S, Yang Y.
europepmc   +1 more source

The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression

International Journal of Molecular Sciences, 2020
Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage.
Yeri Alice Rim, Yoojun Nam, Ji Hyeon Ju
exaly   +2 more sources