Results 261 to 270 of about 118,322 (313)

A biography of the chondrocyte

Annals of the Rheumatic Diseases, 2008
Significant gaps persist in our understanding of chondrocyte biology. We do not know when, how, or even whether these cells are replenished throughout the normal, human life span. We are taught that as much as 90% of the cartilage is "metabolically inert" interterritorial matrix, but we do not know how this substance is regularly replaced (as it is ...
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Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018
BACKGROUND Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily results in warm, swollen, and painful joints. In this study, we investigate the potentially therapeutic role of artesunate (Art) on chondrocyte proliferation ...
Fabo Feng, Hai-Yan Qiu
semanticscholar   +1 more source

Tissue Engineering with Chondrocytes

Facial Plastic Surgery, 2002
Tissue engineering of cartilage, using chondrocytes based on the use of synthetic biodegradable polymer cell delivery vehicles (scaffolds), is an alternate treatment modality for replacing missing cartilage. Cartilage tissue engineering has an important role to play in the generation of graft material for head and neck reconstruction. It is an approach
R James, Koch, Goutham Krishna, Gorti
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Phenotype of chondrocytes in osteoarthritis

Biorheology, 2008
Articular cartilage is composed by a unique cell population, the chondrocytes, embedded in an abundant extra-cellular matrix (ECM). Growth, differentiation and homeostasis of the cartilage are regulated by an intricate interplay between the chondrocytes and ECM, which allows the matrix to send signals to the chondrocytes and the chondrocytes to sense ...
IANNONE, Florenzo, LAPADULA, Giovanni
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Prevention of Chondrocyte Apoptosis

The Journal of Bone and Joint Surgery-American Volume, 2001
The occurrence of chondrocyte apoptosis may be cri­tical in determining the extent of a lesion and sub­sequent repair after mechanical injury to articular cartilage. Agents that prevent apoptosis and increase chondrocyte survival may prove beneficial in the treatment of these ­lesions.
D D, D'Lima, S, Hashimoto, P C, Chen, M K, Lotz, C W, Colwell   +4 more
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In situ chondrocyte viscoelasticity

Journal of Biomechanics, 2012
It has been proposed, based on theoretical considerations, that the strain rate-dependent viscoelastic response of cartilage reduces local tissue and cell deformations during cyclic compressions. However, experimental studies have not addressed the in situ viscoelastic response of chondrocytes under static and dynamic loading conditions. In particular,
Sang-Kuy, Han, Ryan, Madden, Ziad, Abusara, Walter, Herzog   +3 more
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The breakdown of collagen by chondrocytes

The Journal of Pathology, 1980
The chondrocytes of pure articular cartilage from young pigs display collagenolytic activity when the cartilage is cultivated by an organ culture method in medium containing 5--10 IU retinol/ml. Breakdown of collagen occurs in all regions of the cartilage; in the thicker explants it is greatest and most frequent in those that contain the deepest zone ...
R W, Jubb, H B, Fell
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Mitochondrial granules in chondrocytes

Calcified Tissue Research, 1969
Rat and mice epiphyseal growth plates were studied with the electron microscope. A gradient of mitochondrial electron-dense granules was found. Chondrocytes in the proliferative zone had few granules, while those of the succeeding zones showed a gradual increase in number and density until the zone of provisional calcification was reached.
J H, Martin, J L, Matthews
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Culture of Immortalized Chondrocytes and Their Use As Models of Chondrocyte Function

2004
Immortalization of chondrocytes increases life span and proliferative capacity but does not necessarily stabilize the differentiated phenotype. Expansion of chondrocyte cell lines in continuous monolayer culture may result in the loss of phenotype, particularly if high cell density is not maintained. This chapter describes strategies for maintaining or
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Autologous Chondrocyte Transplantation

Clinical Orthopaedics and Related Research, 1999
The intrinsic capacity of cartilage to repair chondral injuries is poor. Different techniques to induce cartilage repair with the use of extrinsic chondrogeneic cell sources have been explored in experimental models. Cells can be harvested autologously or as allografts from a healthy part of the donor tissue, isolated, expanded in vitro, and finally ...
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