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Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Single-cell transcriptome profiling reveals the heterogeneity of ossification of the posterior longitudinal ligament (OPLL) and its immune microenvironment. [PDF]

Cell Biol Toxicol
He Z, Zhou J, Wang F, Guo P, Li J, Zhu Z, Tang T, Tung NTC, Kawaguchi Y, Liu S, Gao M, Liu X, Zhou Z.   +12 more
europepmc   +1 more source

Critical role of Sirtuin 6 (SIRT6) in osteoarthritis chondrocytes: the interaction among various biological processes. [PDF]

Ann Med
Ding N, He Z, Yang Q.
europepmc   +1 more source

Unveiling the potential use of bioprinting materials in directing stem cell fate for cartilage regeneration: Focusing on induced pluripotent stem cells and enhanced lubrication (Review). [PDF]

Med Int (Lond)
Kaushalya GWN, Rajapakse S.
europepmc   +1 more source

Combination of hypoxia and hyperosmolarity reduces <i>in vitro</i> chondrocyte de-differentiation. [PDF]

Front Vet Sci
De Angelis E, Saleri R, Marcotti F, Ferrari L, Cavalli V, Di Lecce R, Zoboli M, Ravanetti F, Passeri B, Martelli P, Borghetti P.   +10 more
europepmc   +1 more source

Mitochondrial quality control modulating chondrocyte behavior and fate in knee osteoarthritis: mechanistic insights and therapeutic prospects. [PDF]

Front Immunol
Li Y, Zhong W, Li L, Zhang F, Duan X, Si H.   +5 more
europepmc   +1 more source

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Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to Rejuvenate Aging Chondrocytes.

ACS Nano, 2023
As chondrocytes from osteoarthritic cartilage usually exhibit aging and senescent characteristics, targeting aging chondrocytes could be a potential therapeutic strategy. In this study, exosomes derived from umbilical cord-derived mesenchymal stem cells (
Hongfu Cao, Manyu Chen, X. Cui, Yuan Liu, Yuhan Liu, Siyan Deng, T. Yuan, Yujiang Fan, Qiguang Wang, Xingdong Zhang   +9 more
semanticscholar   +1 more source

Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis.

Free Radical Biology & Medicine, 2023
Osteoarthritis (OA) is a common degenerative disease of articular cartilage, and there is currently no effective treatment. Baicalein, a flavonoid extracted from plants of the Scutellaria genus, has frequently been used in the past as an anti ...
Yunpeng Wan, K. Shen, Haiyang Yu, Weimin Fan   +3 more
semanticscholar   +1 more source