Results 281 to 290 of about 129,913 (308)

Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to Rejuvenate Aging Chondrocytes

ACS Nano, 2023
As chondrocytes from osteoarthritic cartilage usually exhibit aging and senescent characteristics, targeting aging chondrocytes could be a potential therapeutic strategy. In this study, exosomes derived from umbilical cord-derived mesenchymal stem cells (
Xiaolin Cui, Tun Yuan, Yujiang Fan
exaly   +2 more sources

Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

ACS Applied Materials & Interfaces, 2020
Targeted delivery to the diseased cell or tissue is the key to the successful clinical use of nucleic acid drugs. In particular, delivery of microRNA-140 (miRNA-140, miR-140) into chondrocytes across the dense, nonvascular extracellular matrix of ...
Yujie Liang, Xiao Xu, Jianyi Xiong
exaly   +2 more sources

Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7

Annals of the Rheumatic Diseases, 2022
Objectives To investigate the role of mechanical stress in cartilage ageing and identify the mechanistic association during osteoarthritis (OA) progression.
Haiyan Zhang, Yan Shao, Zihao Yao, Liangliang Liu, Hongbo Zhang, J. Yin, Haoyu Xie, Kai Li, Pinglin Lai, Hua Zeng, G. Xiao, C. Zeng, D. Cai, X. Bai   +13 more
semanticscholar   +1 more source

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis

International Journal of Molecular Sciences, 2015
Apoptosis is a highly-regulated, active process of cell death involved in development, homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as cancer, developmental anomalies and degenerative diseases. Osteoarthritis (OA),
Hyun Ah Kim
exaly   +2 more sources

The art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification

Bone Research, 2018
There is a worldwide epidemic of skeletal diseases causing not only a public health issue but also accounting for a sizable portion of healthcare expenditures.
Patrick Aghajanian, Subburaman Mohan
exaly   +2 more sources

Runx2, an inducer of osteoblast and chondrocyte differentiation

Histochemistry and Cell Biology, 2018
Toshihisa Komori
exaly   +2 more sources

A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation

Development (Cambridge), 2015
Andrew B Lassar, Elazar Zelzer
exaly   +2 more sources

SOX9 and the many facets of its regulation in the chondrocyte lineage

Connective Tissue Research, 2017
Véronique Lefebvre, Mona Dvir-Ginzberg
exaly   +2 more sources

Chondrocyte dedifferentiation and osteoarthritis (OA).

Biochemical Pharmacology, 2019
E. Charlier, C. Deroyer, F. Ciregia, O. Malaise, S. Neuville, Z. Plener, M. Malaise, D. de Seny   +7 more
semanticscholar   +1 more source

The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis

Ageing Research Reviews, 2021
Ziji Zhang, Puyi Sheng, Ali Mobasheri
exaly