Results 111 to 120 of about 1,182,907 (370)

Decellularized Membrane Derived from the Cell-Produced Extracellular Matrix of 1-Day-Old Porcine Cartilage Can Be a Substitute for Periosteal Patches in Autologous Chondrocyte Implantation

Applied Sciences
(1) Autologous chondrocyte implantation (ACI) is a prominent method for treating cartilage damage, but periosteal patches can cause chondrocyte leakage.
Minh-Dung Truong, Thanh-Tam Nguyen-Thi, Thanh-Tan Nguyen-Ngoc, Bich-Tram Vo-Ngoc, Hoang-Yen Duong-Thi, Hoang-Vinh Nguyen, Duc-Quy Mai Hoang, Phuong-Vy Bui, Khanh Hong-Thien Bui, Phuong Le Thi, Dieu Linh Tran, Vo Thi Xuyen   +11 more
doaj   +1 more source

Exposure of a tendon extracellular matrix to synovial fluid triggers endogenous and engrafted cell death: A mechanism for failed healing of intrathecal tendon injuries [PDF]

, 2016
Aim: The purpose of this study was to investigate the effect of normal synovial fluid (SF) on exposed endogenous tendon-derived cells (TDC) and engrafted mesenchymal stem cells (MSCs) within the tendon extracellular matrix. Methods: Explants from equine
Dudhia, J, Garvican, E R, Salavati, M, Smith, R K W   +3 more
core   +3 more sources

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Similarities and differences between rat and mouse chondrocyte gene expression induced by IL-1β

Journal of Orthopaedic Surgery and Research, 2022
Background Osteoarthritis (OA) is the most prevalent degenerative joint disease. In vitro experiments are an intuitive method used to investigate its early pathogenesis.
Dao-Fang Ding, Yan Xue, Jun-Peng Zhang, Zeng-Qiao Zhang, Wen-Yao Li, Yue-Long Cao, Jian-Guang Xu   +6 more
doaj   +1 more source

Dehydrocorydaline Accelerates Cell Proliferation and Extracellular Matrix Synthesis of TNFα-Treated Human Chondrocytes by Targeting Cox2 through JAK1-STAT3 Signaling Pathway [PDF]

, 2022
Yongqiang Sha, Beibei Zhang, Liping Chen, Chunli Wang, Tao Sun   +4 more
openalex   +1 more source

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage. [PDF]

, 2019
The type I TGFβ receptor TGFβRI (encoded by Tgfbr1) was ablated in cartilage. The resulting Tgfbr1 Col2 mice exhibited lethal chondrodysplasia. Similar defects were not seen in mice lacking the type II TGFβ receptor or SMADs 2 and 3, the intracellular ...
Baek, Jongseung, Chun, Hyelim, Lopez, Noah, Lyons, Karen M, Razavi, Peyman, Sadik, Joshua Elyahu, Shirazyan, Anna, Wang, Weiguang   +7 more
core  

Expression and Localization of aquaporin‐1 in Temporomandibular Joint Disc with Internal Derangement [PDF]

, 2012
Background: Internal derangement is the most frequent arthropathy affecting the temporomandibular joint, where its commonest form is anterior disc displacement with or without reduction.
Almeida, Luis Eduardo, Caltabiano, Rosario, Carnazza, Maria Luisa, Galanti, Concetta, Leonardi, Rosalia, Loreto, Carla, Musumeci, Giuseppe, Pannone, Giuseppe   +7 more
core   +2 more sources

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Periodic Mechanical Stress Activates PKCδ-Dependent EGFR Mitogenic Signals in Rat Chondrocytes via PI3K-Akt and ERK1/2

Cellular Physiology and Biochemistry, 2016
Background/Aims: The present study aimed to analyze the mechanisms by which periodic mechanical stress is translated into biochemical signals, and to verify the important role of signaling molecules including phosphatidylinositol-3-kinase (PI3K)-Akt ...
Peng He, Nan Shen, Gongming Gao, Xuefeng Jiang, Huiqing Sun, Dong Zhou, Nanwei Xu, Luming Nong, Kewei Ren   +8 more
doaj   +1 more source

LOXL2 in anabolic response to chondrodysplasia mice progressive TMJ and knee osteoarthritis [PDF]

, 2019
Osteoarthritis (OA) is a degenerative joint disease that affects an estimated 9.6 % of men and 18 % of women over 60 years of age. However, there is no chondroprotective agent that is approved for clinical application.
Alsaqer, Saqer
core