Results 121 to 130 of about 38,240 (159)

Influence of ion channels on the proliferation of human chondrocytes

Biorheology: The Official Journal of the International Society of Biorheology, 2002
The goal of the study was to examine connections between ion channel activity and the proliferation of human chondrocytes. Chondrocytes were isolated form human osteoarthritic knee joint cartilage. In this study the concentration‐dependent influence of the ion channel modulators tetraethylammonium (TEA), 4‐aminopyridine (4‐AP), 4
David, Wohlrab, Susanne, Lebek, Thomas, Krüger, Heiko, Reichel   +3 more
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FBLN1 promotes chondrocyte proliferation by increasing phosphorylation of Smad2

Journal of Orthopaedic Science, 2022
The role of fibulin-1 or FBLN1 in chondrocyte proliferation has not been reported so far. In this study, we aimed to verify whether FBLN1 promotes chondrocyte proliferation in elderly patients with knee osteoarthritis by phosphorylating Smad2.Chondrocytes were isolated from cartilage samples collected from elderly patients with osteoarthritis (n = 6 ...
Gang, Xu, Xiang, Geng, Fan, Yang, Haijiao, Zhang   +3 more
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Mechanical compression modulates proliferation of transplanted chondrocytes

Journal of Orthopaedic Research, 2000
AbstractThe presence of an appropriate number of reparative cells in an articular cartilage defect is probably necessary for consistent and successful repair. Following the transplantation of chondrocytes into a defect, cell proliferation may modulate local defect cellularity.
K W, Li, Y H, Falcovitz, J P, Nagrampa, A C, Chen, L M, Lottman, J Y, Shyy, R L, Sah   +6 more
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Cell cycle genes in chondrocyte proliferation and differentiation

Matrix Biology, 1999
Coordinated proliferation and differentiation of growth plate chondrocytes controls longitudinal growth of endochondral bones. While many extracellular factors regulating these processes have been identified, much less is known about the intracellular mechanisms transducing and integrating these extracellular signals. Recent evidence suggests that cell
F, Beier, T A, Leask, S, Haque, C, Chow, A C, Taylor, R J, Lee, R G, Pestell, R T, Ballock, P, LuValle   +8 more
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Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation

Journal of Bone and Mineral Metabolism, 2010
Runx2 plays important roles in the regulation of chondrocyte differentiation and proliferation; however, the Runx2 target molecules still remain to be investigated. We searched the genes upregulated by the introduction of Runx2 into Runx2(-/-) chondrocytes using microarray and found that Tcf7 is upregulated by Runx2.
Masaki, Mikasa, Satoshi, Rokutanda, Hisato, Komori, Kosei, Ito, Ying Sze, Tsang, Yuki, Date, Carolina A, Yoshida, Toshihisa, Komori   +7 more
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Suppression of growth plate chondrocyte proliferation by corticosteroids

Pediatric Nephrology, 2000
Growth depression is a side effect of high-dose glucocorticoid therapy in childhood. It is partially mediated by alterations of the somatotropic hormone axis and partially by direct local effects on growth plate chondrocytes. The mechanisms of interaction of corticosteroids and somatotropic and calciotropic hormones at the cellular level were recently ...
G, Klaus, C, Jux, P, Fernandez, J, Rodriguez, R, Himmele, O, Mehls   +5 more
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Inhibition effect of osthole on proliferation of rat chondrocytes

Journal of Chinese Integrative Medicine, 2012
To investigate the effects of osthole on chondrocyte proliferation in vitro.Primary rat chondrocytes were isolated from the femoral head of newborn rats using collagenase digestion and cultured in Dulbecco's modified Eagle's medium. The proliferation of primary chondrocytes was assessed in second-passage cultures using cell counting kit-8 and the ...
Dao-fang, Ding, Song-pu, Wei, Xiao-feng, Li, Xiao-gang, Zhang, Hong-sheng, Zhan, Tie-li, Duan, Yue-long, Cao   +6 more
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Modulation of chondrocyte proliferation by ascorbic acid and BMP‐2

Journal of Cellular Physiology, 1998
Chondrocytes show an unusual ability to thrive under serum-free conditions as long as insulin, thyroxine, and cysteine are present. Studies with sternal chondrocytes from chick embryos indicate that thymidine incorporation in chondrocytes cultured under serum-free conditions is 30-50% of that seen with fetal bovine serum (FBS).
R, Venezian, B J, Shenker, S, Datar, P S, Leboy   +3 more
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GDF15 enhances proliferation of aged chondrocytes by phosphorylating SMAD2

Journal of Orthopaedic Science, 2022
Aging is one of the primary factors influencing development of osteoarthritis, and the TGF-β pathway plays an important role in age-related osteoarthritis. Specifically, GDF15 phosphorylates SMAD2/3 in the TGF-β pathway to inhibit cardiomyocyte hypertrophy, and promote proliferation of chondrocytes.
Dongming, Wang, Xiaochun, Wei, Xiang, Geng, Pengcui, Li, Lu, Li   +4 more
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Autologous chondrocyte implantation: cells phenotype and proliferation analysis

Knee Surgery, Sports Traumatology, Arthroscopy, 2001
AbstractThe phenotype and proliferation of human chondrocytes in culture were analyzed before they were implanted as autologous graft in cartilage lesions. During ten autologous chondrocyte implantations in articular cartilage lesions of the knee in ten patients, small amounts of cells to be implanted were collected and analyzed by morphology ...
A, Gigante, C, Bevilacqua, C, Zara, M, Travasi, C, Chillemi   +4 more
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