Results 91 to 100 of about 222,465 (345)

Development of a peptide-siRNA nanocomplex targeting NF- κB for efficient cartilage delivery [PDF]

, 2019
Delivery of therapeutic small interfering RNAs (siRNAs) in an effective dose to articular cartilage is very challenging as the cartilage dense extracellular matrix renders the chondrocytes inaccessible, even to intra-articular injections. Herein, we used
Akk, Antonina, Duan, Xin, Pan, Hua, Pham, Christine T. N., Rai, Muhammad Farooq, Sandell, Linda J., Wickline, Samuel A., Yan, Huimin   +7 more
core   +3 more sources

The Synergy of Artificial Intelligence and 3D Bioprinting: Unlocking New Frontiers in Precision and Tissue Fabrication

Advanced Functional Materials, EarlyView.
Advances in integrating artificial intelligence into 3D bioprinting are systematically reviewed here. Machine learning, computer vision, robotics, natural language processing, and expert systems are examined for their roles in optimizing bioprinting parameters, real‐time monitoring, quality control, and predictive maintenance.
Joao Vitor Silva Robazzi, Irem Deniz Derman, Deepak Gupta, Logan Haugh, Yogendra Pratap Singh, Vaibhav Pal, Yasar Ozer Yilmaz, Suihong Liu, Andre Luis Dias, Rogerio Andrade Flauzino, Ibrahim Tarik Ozbolat   +10 more
wiley   +1 more source

Kaempferol Alleviates the Interleukin-1β-Induced Inflammation in Rat Osteoarthritis Chondrocytes via Suppression of NF-κB

Medical Science Monitor, 2017
Background This study was designed to examine the anti-inflammatory and anti-osteoarthritis (OA) effects of kaempferol in rat articular chondrocytes stimulated with interleukin-1β.
Zhengling Zhuang, Guang-ming Ye, Bin Huang   +2 more
semanticscholar   +1 more source

A Twist in the Diagnosis: Chronic Arthropathy Without Inflammation

Arthritis Care &Research, EarlyView.
María Á. Puche‐Larrubia, Inmaculada C. Aranda‐Valera, Alejandro Escudero‐Contreras, Rosa Roldán‐Molina   +3 more
wiley   +1 more source

Revealing the Auxetic Behavior of Biomimetic Multimaterial and Region‐Specific Nanofibrous Fascicle‐Inspired Scaffolds via Synchrotron Multiscale Digital Volume Correlation: Innovative Building Blocks for the Enthesis Regeneration

Advanced Functional Materials, EarlyView.
Enthesis injuries are a worldwide healthcare problem. Biomimetic electrospun enthesis fascicle‐inspired scaffolds, with and without nano‐mineralization are developed. Human Mesenchymal Stromal cells (hMSCs) express the most balanced enthesis markers on the non‐mineralized scaffolds.
Alberto Sensini, Francesca Giacomini, Olga Stamati, Bratislav Lukic, Julie Villanova, Henry Proudhon, Maryse Gille, Zeinab Tahmasebi Birgani, Roman Truckenmüller, Gianluca Tozzi, Martijn van Griensven, Lorenzo Moroni   +11 more
wiley   +1 more source

ACTIVITY OF CANONICAL WNT SIGNAL SYSTEM IN HYALINE CARTILAGE ARTICULAR CHONDROCYTES IN PROCESS OF SYNOVIAL JOINT DEVELOPMENT [PDF]

Саратовский научно-медицинский журнал, 2009
Canonical and non-canonical Wnt systems are essential regulators of chondrogenesis and bone development. However, the roles of these systems in synovial joint development are not well studied.
A.O. Molotkov, S.L. Kuznetsov
doaj  

Cell Death in Chondrocytes, Osteoblasts, and Osteocytes

International Journal of Molecular Sciences, 2016
Cell death in skeletal component cells, including chondrocytes, osteoblasts, and osteocytes, plays roles in skeletal development, maintenance, and repair as well as in the pathogenesis of osteoarthritis and osteoporosis.
T. Komori
semanticscholar   +1 more source

Thyroxine is the serum factor that regulates morphogenesis of columnar cartilage from isolated chondrocytes in chemically defined medium. [PDF]

, 1994
Epiphyseal chondrocytes cultured in a medium containing 10% serum may be maintained as three dimensional aggregates and differentiate terminally into hypertrophic cells.
Ballock, RT, Reddi, AH
core  

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

MicroRNA-34a and MicroRNA-181a Mediate Visfatin-Induced Apoptosis and Oxidative Stress via NF-κB Pathway in Human Osteoarthritic Chondrocytes

Cells, 2019
Current evidence suggests a complex interaction between adipokines and microRNA (miRNA) in osteoarthritis (OA) pathogenesis. The present study explored the role of miR-34a and miR-181a in regulating apoptosis and oxidative stress induced by visfatin in ...
Sara Cheleschi, Sara Tenti, Nicola Mondanelli, Claudio Corallo, Marcella Barbarino, Stefano Giannotti, Ines Gallo, Antonio Giordano, Antonella Fioravanti   +8 more
doaj   +1 more source