Results 111 to 120 of about 213,570 (404)
Recent progress in cartilage lubrication [PDF]
arXiv, 2023 Healthy articular cartilage, covering the ends of bones in major joints such as hips and knees, presents the most efficiently-lubricated surface known in nature, with friction coefficients as low as 0.001 up to physiologically high pressures. Such low friction is indeed essential for its well being.
arxiv
Advanced Healthcare Materials, EarlyView.Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia +7 more
wiley +1 more source
Discerning the spatio-temporal disease patterns of surgically induced OA mouse models [PDF]
, 2019 Osteoarthritis (OA) is the most common cause of disability in ageing societies, with no effective therapies available to date. Two preclinical models are widely used to validate novel OA interventions (MCL-MM and DMM).
Becker, Jessica +8 more
core +3 more sources
Are Paralysed Chondrocytes Really Dying? [PDF]
arXiv, 2017 The aims of the current study were to establish a system of culture for induction of paralysed chondrocytes and to investigate if these cells are really dying. Chondrocytes were isolated from the growth cartilage of fetal equines, centrifuged and cultured as pellets in either 10% fetal calf serum or 10% horse serum for 28 days and processed for light ...
arxiv
Time-of-flight secondary ion mass spectrometry-based molecular distribution distinguishing healthy and osteoarthritic human cartilage [PDF]
, 2013 Osteoarthritis (OA) is a pathology that ultimately causes joint destruction. The cartilage is one of the principal affected tissues. Alterations in the lipid mediators and an imbalance in the metabolism of cells that form the cartilage (chondrocytes) have been described as contributors to the OA development.
arxiv +1 more source
Chondrocytes and their matrix [PDF]
Nature, 1980 Biology of Cartilage Cells. By R.A. Stockwell. Pp.329. (Cambridge University Press: London, New York and Melbourne, 1979.) £25.
openaire +1 more source
Effects of mechanical stress on chondrocyte phenotype and chondrocyte extracellular matrix expression [PDF]
Scientific Reports, 2016 AbstractMechanical factors play a key role in regulating the development of cartilage degradation in osteoarthritis. This study aimed to identify the influence of mechanical stress in cartilage and chondrocytes. To explore the effects of mechanical stress on cartilage morphology, we observed cartilages in different regions by histological and ...
Xiaoning Duan +6 more
openaire +3 more sources
Pyrophosphate‐Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality
Advanced Healthcare Materials, EarlyView.The role of calcium pyrophosphate (Ca‐PP) in heterotopic bone formation and material degradation is investigated using calcium phosphate (CaP) compositions with varying Ca‐PP content. Results show that Ca‐PP does not impede heterotopic bone formation, minimally affects CaP degradation at non‐osseous sites, and increases phagocytosis.
Martina Jolic +7 more
wiley +1 more source
CCL2 induces articular chondrocyte MMP expression through ERK and p38 signaling pathways
Osteoarthritis and Cartilage Open, 2021 Objective: In previous studies, we determined an association between increased serum and articular cartilage levels of CCL2 with osteoarthritis (OA) progression, cartilage damage and increased MMP13 in cartilage.
Helen Willcockson +4 more
doaj
Mediators of Inflammation, 2021 Background. In the past decade, mesenchymal stem cells (MSCs) have been widely used for the treatment of osteoarthritis (OA), and noncoding RNAs in exosomes may play a major role. Aim.
Honggang Xu, Bin Xu
doaj +1 more source