Results 111 to 120 of about 97,024 (315)

Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function

Advanced Science, EarlyView.
Nestin localizes to the mitochondrial IMS through its MTS and the TOM20 import machinery. Within the mitochondria, Nestin interacts with Mic60 via its C‐terminal Tail3 domain. Loss of mitochondrial Nestin disrupts cristae architecture, leading to mitochondrial swelling, bioenergetic dysfunction, and ultimately the senescence of hMSCs.
Hainan Chen, Jinsi Chen, Li Huang, Xingqiang Lai, Kai Xia, Qiying Lu, Bingbing Xie, Yinong Huang, Yuan Qiu, Tao Wang, Jianqi Feng, Yuanjun Guan, Siyao Che, Jiancheng Wang, Andy Peng Xiang   +14 more
wiley   +1 more source

Regulation of ferroptosis in osteoarthritis and osteoarthritic chondrocytes by typical MicroRNAs in chondrocytes

Frontiers in Medicine
Osteoarthritis (OA) is a progressive degenerative disorder impacting bones and joints, worsened by chronic inflammation, immune dysregulation, mechanical stress, metabolic disturbances, and various other contributing factors. The complex interplay of cartilage damage, loss, and impaired repair mechanisms remains a critical and formidable aspect of OA ...
Qingyuan Yu, Yanan Xiao, Mengqi Guan, Guohui Zhou, Xianshuai Zhang, Jianan Yu, Mingze Han, Wei Yang, Yan Wang, Zhenhua Li   +9 more
openaire   +3 more sources

A Novel Therapeutic Strategy for Bone Marrow Failure: Niche Rejuvenation Using Costal Cartilage‐Derived Stem Cells

Advanced Science, EarlyView.
CDSCs exhibit the potential to differentiate into endothelial cells, vascular pericytes, and osteoblasts. These differentiated cells are capable of secreting additional pro‐hematopoietic cytokines. Furthermore, CDSCs can inhibit apoptosis and reduce DNA damage in injured hematopoietic stem and progenitor cells (HSPCs, including RHSCs and RHPCs), while ...
Rui Dong, Zhiguo Ling, Pengyuan Fan, Debao Li, Jinsong Wang, Wenjiong Shi, Rui Zuo, Runfeng Chen, Xuemin Sun, Lang Xiao, Yushi Ran, Shucheng Huang, Yi Tian, Chao Zhang, Yuzhang Wu, Bing Ni, Yi Zhang   +16 more
wiley   +1 more source

Smart Gated Hollow Mesoporous Silica Hydrogel for Targeting Endoplasmic Reticulum Stress and Promoting Periodontal Tissue Regeneration

Advanced Science, EarlyView.
The hollow mesoporous silica loaded with quercetin (HM‐QU@PEG) is combined with a thermosensitive anti‐bacterial matrix (TF127) to prepare HQUP@TF127. HQUP@TF127 effectively eliminates excessive ROS, alleviates endoplasmic reticulum stress, relieves mitochondrial calcium overload, and blocks the p53‐dependent apoptotic cascade. Furthermore, it enhances
Guichun Wang, Yuxiao Wang, Yang Ding, Xiang Chen, Shuhan Li, Wenqi Zhou, Rui Ma, Maomao Tang, Xinyuan Shao, Zixuan Shu, Ning He, Xiaodong Ma, Jian Guo, Chengjun Peng, Shuangying Gui   +14 more
wiley   +1 more source

Differential localization of mRNAs of collagen types I and II in chick fibroblasts, chondrocytes, and corneal cells by in situ hybridization using cDNA probes. [PDF]

, 1986
Miyuki Hayashi, Y Ninomiya, J. Parsons, K. HAYASHI, Bjørn R. Olsen, Robert L. Trelstad   +5 more
openalex   +1 more source

Effect of Somatomedin-C/Insulin-Like Growth Factor I and Growth Hormone on Cultured Growth Plate and Articular Chondrocytes [PDF]

, 1989
Stephen B. Trippel, M.T. Corvol, M.-F. Dumontier, R Rappaport, Hsin‐I Hung, Henry J. Mankin   +5 more
openalex   +1 more source

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen, Chenhao Che, Lingjie Wu, Changjie Sun, Dongming Xu, Qinyang Hua, Yunzhong Zhang, Yi‐Quan Tang, Peng Shi, Shan Sun   +9 more
wiley   +1 more source

Type X collagen synthesis during in vitro development of chick embryo tibial chondrocytes. [PDF]

, 1986
Patrizio Castagnola, G Moro, Fiorella DESCALZI‐CANCEDDA, Ranieri Cancedda   +3 more
openalex   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Synthesis of Proteochondroitin Sulfate by Normal, Nanomelic, and 5-Bromodeoxyuridine-Treated Chondrocytes in Cell Culture

, 1972
Marshall J. Palmoski, Paul F. Goetinck
openalex   +1 more source