Results 311 to 320 of about 222,465 (345)

The role of FoxO3a in the pathogenesis of osteoarthritis and its therapeutic applications. [PDF]

Front Immunol
Wu Z, Wang X, Yang Y, Xia C, Lou L, Fei W, Wang J, Dai J.   +7 more
europepmc   +1 more source

Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases

Small Science, EarlyView.
This review analyzes immunomodulatory biomaterial strategies for treating chronic inflammatory disorders in bone and soft tissues. It explores emerging mechanisms for resolving inflammation while promoting tissue regeneration, offering insights for developing targeted immunotherapeutic approaches that bridge material science with immunology for ...
Yiming Li, Xudong Xie, Chong Ding, Shengming Zhang, Liangcong Hu, Bobin Mi, Mengfei Liu, Guohui Liu   +7 more
wiley   +1 more source

Properties and Functions of Myochondrocytes and Myochondroblasts in Different Human Cartilage Tissues-An Overview. [PDF]

Cells
Povýšil C, Kaňa R, Horák M, Kaňa M.
europepmc   +1 more source

Exosome‐Based Cartilage‐Targeted Delivery System: Strategies and Applications

Small Science, EarlyView.
Construction strategies and applications of cartilage‐targeting exosomes. With the ageing of the global population, cartilage‐related diseases, such as osteoarthritis (OA) and intervertebral disc degeneration (IVDD), have increasingly become significant social problems threatening human health. Therefore, targeted therapy for cartilage is becoming more
Yao Wang, Bo Chen, Haodong Zhu, Zhenyu Sun   +3 more
wiley   +1 more source

Chondrocyte‐Targeted Nanoparticles Loaded with N‐Acetylcysteine Protect Articular Cartilage and Attenuate Osteoarthritis by Inhibiting Ferroptosis via Glutathione Maintenance

Small Science, EarlyView.
Chondrocyte‐targeted CS‐NAC nanoparticles restore redox balance, inhibit ferroptosis, and protect cartilage under mechanical stress. This nanoplatform enhances joint retention, elevates GPX4 activity, and attenuates osteoarthritis progression, offering a promising disease‐modifying therapeutic strategy.
Shaoyi Wang, Fujian Zhang, Xiaocong Zhou, Jie Yang, Zhe Li, Songlin Li, Qunshan Lu, Houyi Sun, Peilai Liu   +8 more
wiley   +1 more source

CAP-CD56⁺CD271⁺ BMSCs exos-loaded PVA/SA sustained-release hydrogel attenuates chondrocyte senescence and ameliorates lumbar facet joint osteoarthritis. [PDF]

Bioact Mater
Xie Y, Liu Q, Tan J, Lu Y, Li Y, Ye H, Xu Z, Wang M, Wang C, Li X, Xue J, Yan Y.   +11 more
europepmc   +1 more source

Emerging roles of long non-coding RNAs in osteoarthritis: from molecular mechanisms to therapeutic opportunities. [PDF]

RNA Biol
Zhao Y, Zhang Y, Peng Y, Zheng Z, Li Q, Shen J, Wang H, Liu F.   +7 more
europepmc   +1 more source

Retinoic Acid-Loaded Cartilage Organoids Attenuate Chondrocyte Senescence in Osteoarthritis. [PDF]

J Inflamm Res
Xi L, Chen Y, Luo Z, Zhang D.
europepmc   +1 more source

FKBP38 Alleviates Osteoarthritis Progression by Inhibiting Chondrocyte Senescence. [PDF]

Cartilage
Wu J, Chen W, Zou Z, Li H, Zhou T, Liao Z, Rao Z, Li K, Tan X, Cao H, Wang H.   +10 more
europepmc   +1 more source

IRS2/FOXO1 mitigates osteoarthritis by regulating chondrocyte autophagy and mitochondrial function. [PDF]

Mol Med
Qin C, Chen K, Sun Y, Wang C, Yu Y, Zhu H, Zou G.   +6 more
europepmc   +1 more source