cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis. [PDF]
Cell Death DisZhang Y, Zhu Z, Ji P, Ming J, Zhou Y.
europepmc +1 more source
A Clinical Study of the Distribution and Morphology of Harris Lines
Archaeometry, EarlyView.ABSTRACT Harris lines are commonly used in bioarcheology to infer lifestyle in ancient populations; however, their etiology and identification parameters are still under debate. The aim of this study is to observe the distribution of the lesions in a contemporary clinical sample to address their association with etiological factors, age, biological sex,
Claudia Moro +7 more
wiley +1 more source
IMMT downregulation promotes osteoarthritis development by inducing mitochondrial dysfunction. [PDF]
J Orthop Surg ResYang L, Wang B, Ma Q, Wang J, Cheng Y.
europepmc +1 more source
Biochemical bone biomarkers in plasma cell dyscrasias
British Journal of Haematology, EarlyView.Visual abstract depicting that bone turnover markers reflect dynamic alterations in bone remodelling across the spectrum of plasma cell dyscrasias but remain limited by assay variability, biological confounding and incomplete integration with imaging and risk stratification.
Guido Nador +4 more
wiley +1 more source
Effect of lncRNA Zeb1-As1 on Il-1B-Induced Chondrocyte Injury by Regulating Mir-330-3p Expression
, 2020 Wei Dai +4 more
openalex +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
Propionate attenuates osteoarthritis progression by regulating the gut-joint axis. [PDF]
Front ImmunolHan S +7 more
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mTOR signaling in skeletal development and disease [PDF]
, 2018 Chen, Jianquan, Long, Fanxin
core +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Role of WIF-1 in regulating chondrocyte dedifferentiation and matrix production through WNT pathway. [PDF]
Regen TherChu YY +6 more
europepmc +1 more source