Results 361 to 370 of about 214,417 (382)
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Current Protocols in Pharmacology, 2001
AbstractChondrocytes constitute the sole cell type found within cartilage, and control the formation and composition of cartilage. Cellular, biochemical and pharmacological studies of arthritis and other cartilage disorders have increasingly focused on chondrocyte function.
Ronald L. Goldberg, Jeffrey M. Liebman
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AbstractChondrocytes constitute the sole cell type found within cartilage, and control the formation and composition of cartilage. Cellular, biochemical and pharmacological studies of arthritis and other cartilage disorders have increasingly focused on chondrocyte function.
Ronald L. Goldberg, Jeffrey M. Liebman
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Chondrocytes in Aging Research
1979Publisher Summary Chondrocytes or cells derived from cartilaginous tissues represent a highly differentiated cell type and they synthesize and secrete a unique and specific protein, Type II collagen. Collagen synthesis is studied in a variety of systems utilizing cells derived from different tissues of a number of species. Populations of chondrocytes
E J, Miller, S, Gay
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Arthritis & Rheumatism, 2013
OBJECTIVE To examine the effect of different sources of good manufacturing practice clinical grade adipose-derived mesenchymal stem cells (AD-MSCs) on inflammatory factors in osteoarthritic (OA) chondrocytes and synoviocytes.
C. Manferdini +11 more
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OBJECTIVE To examine the effect of different sources of good manufacturing practice clinical grade adipose-derived mesenchymal stem cells (AD-MSCs) on inflammatory factors in osteoarthritic (OA) chondrocytes and synoviocytes.
C. Manferdini +11 more
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The breakdown of collagen by chondrocytes
The Journal of Pathology, 1980The chondrocytes of pure articular cartilage from young pigs display collagenolytic activity when the cartilage is cultivated by an organ culture method in medium containing 5--10 IU retinol/ml. Breakdown of collagen occurs in all regions of the cartilage; in the thicker explants it is greatest and most frequent in those that contain the deepest zone ...
Honor B. Fell, R. W. Jubb
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Autophagy modulates osteoarthritis-related gene expression in human chondrocytes.
Arthritis & Rheumatism, 2012OBJECTIVE Autophagy, an evolutionarily conserved process for the bulk degradation of cytoplasmic components, serves as a cell survival mechanism. The purpose of this study was to elucidate the role of autophagy in human chondrocytes and pathophysiology ...
H. Sasaki +9 more
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Culture of Immortalized Chondrocytes and Their Use As Models of Chondrocyte Function
2004Immortalization of chondrocytes increases life span and proliferative capacity but does not necessarily stabilize the differentiated phenotype. Expansion of chondrocyte cell lines in continuous monolayer culture may result in the loss of phenotype, particularly if high cell density is not maintained. This chapter describes strategies for maintaining or
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Journal of Cellular Physiology, 1994
AbstractThe objectives of this study were to establish a growth factor response profile for adult human articular chondrocytes, to determine whether this is unique for chondrocytes or influenced by the differentiation status of the cells, and to characterize growth factor interactions.
Pierre-André Guerne +2 more
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AbstractThe objectives of this study were to establish a growth factor response profile for adult human articular chondrocytes, to determine whether this is unique for chondrocytes or influenced by the differentiation status of the cells, and to characterize growth factor interactions.
Pierre-André Guerne +2 more
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Transplantation of Isolated Chondrocytes
Clinical Orthopaedics and Related Research, 1991Intramuscular transplantation of isolated syngeneic chondrocytes from hyaline and elastic cartilage results in formation of cartilage with various degrees of similarity to the original tissue. Cells from cartilage with a simple structure, such as nasal septal cartilage, form islands of tissue with flattened chondrocytes at the periphery and more ...
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Chondrocyte Proliferation and Differentiation
2011The skeletal elements of the axial and appendicular skeleton are preformed as cartilage templates by a mechanism called endochondral ossification. During this process, a cartilage template is formed in which chondrocytes proliferate and differentiate into hypertrophic chondrocytes and are gradually replaced by bone.
Manuela Wuelling, Andrea Vortkamp
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2005
We have little systematic information to explain the heterogeneity of cartilage and bones as tissue, or of chondrocytes and osteocytes as differentiated cells. Does heterogeneity originate in the initial determination or setting-aside of precursor cells for chondrogenesis or is it an aspect of later stages of chondrocyte differentiation?
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We have little systematic information to explain the heterogeneity of cartilage and bones as tissue, or of chondrocytes and osteocytes as differentiated cells. Does heterogeneity originate in the initial determination or setting-aside of precursor cells for chondrogenesis or is it an aspect of later stages of chondrocyte differentiation?
openaire +3 more sources