ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro +5 more
wiley +1 more source
The ontogenetic development, innervation, and morphology of the shoulder joint and forelimb muscles were investigated in 11 anuran species. The results reveal largely conserved splitting patterns of the dorsal and ventral pre‐muscle masses, alongside interspecific variation in muscle subdivision and morphology.
Robin Saulnier Masson, Karolin Engelkes
wiley +1 more source
ABSTRACT This study evaluated the effects of puerarin and adipose‐derived stem cells (ADSCs), alone or combined, on p38MAPK activity, alveolar bone preservation, and inflammatory responses in a rat periodontitis (PD) model and in vitro. ADSCs were exposed to various puerarin concentrations to assess cell proliferation, osteogenic differentiation, and ...
Ting Yang, Xu Zhang, Liang‐Fu Zhang
wiley +1 more source
ABSTRACT Background Postoperative complications substantially increase morbidity, mortality and healthcare costs. Understanding prognostic factors is essential for risk stratification, targeted prevention strategies, and development of prediction models.
Anders Peder Højer Karlsen +15 more
wiley +1 more source
Revisiting Pluripotency Acquisition: A Unified Framework for Reprogramming Strategies
ABSTRACT The traditional hierarchical view of totipotent cells generating diverse lineages of terminally differentiated cells was challenged by the discovery of induced pluripotent stem cells (iPSCs). This breakthrough demonstrated that the ectopic expression of four transcription factors, Oct4, Sox2, Klf4, and c‐Myc (OSKM), can reprogram somatic cells
Anamika Datta, Kunimasa Ohta
wiley +1 more source
ABSTRACT Background The mid‐palatal suture is a key growth site for transverse maxillary expansion, yet the cellular mechanisms governing its postnatal development and response to mechanical loading remain poorly defined. This study investigated the contribution of chondrocyte‐derived osteogenesis to maxillary bone formation and the influence of ...
Michael Stark +5 more
wiley +1 more source
Species-specific roles of cellular communication network proteins in cartilage development: A comparative study using in vitro chondrogenic models. [PDF]
Wang Z +9 more
europepmc +1 more source
Role of external forces in the mechanobiology of stem and differentiated chondrogenic cells embedded in a tissue-engineered construct for cartilage repair. [PDF]
Cordeiro MC +3 more
europepmc +1 more source
Fibroblast Growth Factor 2-Immobilized Biointerfaces Drive Exogenous Transforming Growth Factor β1-Independent Chondrogenesis of Human Mesenchymal Stem Cell and Ectopic Cartilage Tissue Formation. [PDF]
Jeong JH +10 more
europepmc +1 more source
Dichotomous SMAD2/3 regulation and selective antihypertrophic activity of heparin during in vitro chondrogenesis of mesenchymal stromal cells. [PDF]
Schmidt S +8 more
europepmc +1 more source

