Results 131 to 140 of about 21,815 (286)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Activity of chondroitin ABC lyase and hyaluronidase on free-radical degraded chondroitin sulfate

open access: yes, 1995
High molecular mass-chondroitin sulfate was characterized for M(r), charge density and constituent disaccharides. This glycosaminoglycan was depolymerized by a controlled free-radical process mediated by hydrogen peroxide in the absence or presence of ...
VOLPI, Nicola, Venturelli T., Sandri I
core  

Diverse reactivity of maleimides in polymer science and beyond

open access: yesPolymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick   +2 more
wiley   +1 more source

Chondroitin 4-O-sulfotransferase-2 regulates the number of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1

open access: yes, 2011
Recently, it has been shown that a deficiency in ChGn-1 (chondroitin N-acetylgalactosaminyltransferase-1) reduced the numbers of CS (chondroitin sulfate) chains, leading to skeletal dysplasias in mice.
Toshiyasu Koike   +2 more
core   +1 more source

Combining radiotherapy with CAR‐T cell therapy for solid tumors: Challenges, mechanisms, and future directions

open access: yesPrecision Radiation Oncology, EarlyView.
Radiotherapy enhances CAR‐Tcell therapy by increasing antigenicity, improving trafficking, and reshaping the tumor microenvironment. Despite its dual effects, including potential immune suppression, understanding these mechanisms enables the development of strategies to maximize synergy in solid tumors.
Leran Qiu   +4 more
wiley   +1 more source

Chondroitin sulfate and joint disease

open access: yes, 1998
SummaryChondroitin sulfate is an important and major component of articular cartilage, where it occurs as part of the large proteoglycan, aggrecan. In the early stages of joint disease, both in animal models and in man, there are change in chondroitin ...
Hardingham, Tim
core   +1 more source

Systematic review of systematic reviews on the effect of orally administered glucosamine and/or chondroitin sulfate on osteoarthritis outcomes

open access: yesZhongguo shipin weisheng zazhi
ObjectiveTo track recent progress in the evaluation of orally administered glucosamine and/or chondroitin sulfate for osteoarthritis-related outcomes, and reanalyze the evaluation results.MethodsDatabase (CNKI, PUBMED and Cochrane Library) were searched ...
ZHI Yuan   +3 more
doaj   +1 more source

The pharmacokinetics of chondroitin sulfate

open access: yes, 2005
The pharmacokinetics of chondroitin ...
VOLPI, Nicola
core  

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