Results 191 to 200 of about 95,525 (355)

Physical activity and joint health: Implications for knee osteoarthritis disease pathophysiology and mechanics

Experimental Physiology, EarlyView.
Abstract Knee osteoarthritis is experienced by hundreds of millions of people worldwide and is a major cause of disability. Although enhancing physical activity levels and the participation in exercise programmes has been proved to improve the debilitating illness of osteoarthritis, many do not engage in recommended levels of physical activity.
Karl Morgan, Joshua Carter, Dario Cazzola, Jean‐Philippe Walhin   +3 more
wiley   +1 more source

The role of chondroitin sulfate in venous thrombosis, organization, and resolution. [PDF]

Am J Physiol Heart Circ Physiol
Lamenza FF, Kessinger CW.
europepmc   +1 more source

Structural basis of chemokine interactions with heparan sulfate, chondroitin sulfate, and dermatan sulfate [PDF]

, 2019
Krishna Mohan Sepuru, Krishna Rajarathnam   +1 more
openalex   +1 more source

Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 1, March 2026.
This study investigated the combined effects of dynamic compression and torsion with major pro‐catabolic cytokine interleukin‐1 beta (IL‐1β) and its inhibitor: interleukin‐1 receptor antagonist (IL‐1Ra), on bovine IVD in an ex vivo organ culture system and further evaluated the mechanical effects using a subject‐personalized finite element model based ...
Katherine B. Crump, Estefano Muñoz‐Moya, Kim de Graaf, Paola Bermudez‐Lekerika, Nicole Schwendener, Wolf‐Dieter Zech, Christine L. Le Maitre, Jérôme Noailly, Benjamin Gantenbein   +8 more
wiley   +1 more source

Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
Non‐canonical glycopeptides of the proteoglycan linkage region are accessible by the enzymes B3GalT6 and GlcAT‐1 confirming a recently discovered rescue mode in glycosaminoglycan (GAG) biosynthesis. The crystal structure of B3GalT6 revealed a covalent dimer linked by a disulfide. Abstract We selected the N,O‐glycosylated proteoglycan bikunin as a model
Sascha Weidler, Ole Bundgaard, Markus Hessefort, Marisa Rädisch, Christopher Günther Franz Graf, Kevin Lam, Vanessa J. Neubauer, Johanna Eisenreich, Leonhard Köhler, Kelley W. Moremen, Catharina Steentoft, Henrik Clausen, Teng‐Yi Huang, Shang‐Cheng Hung, Clemens Steegborn, Michael Weyand, Carlo Unverzagt   +16 more
wiley   +2 more sources

Structural basis for human chondroitin sulfate chain polymerization. [PDF]

Nat Commun
Dutta P, Cordeiro RL, Friedel-Arboleas M, Bourgeais M, Vallet SD, Weber M, Molinas M, Shu H, Grønset MNN, Miller RL, Boeri Erba E, Wild R.   +11 more
europepmc   +1 more source

Subcellular localization of the synthesis and glycosylation of chondroitin sulfate proteoglycan core protein.

, 1984
M. Geetha-Habib, Steven C. Campbell, Nancy B. Schwartz   +2 more
openalex   +1 more source

Influence of the Intervertebral Disc Microenvironment on Matrix Synthesis and Metabolism in Goat Nucleus Pulposus Cells

JOR SPINE, Volume 9, Issue 1, March 2026.
Goat nucleus pulposus cells cultured under clinically relevant oxygen, glucose, pH, and osmolarity revealed pH to have the most influential impact on viability and glycosaminoglycan synthesis. Interactions between factors showed that disc cell behavior is shaped by the microenvironment, highlighting its importance in regenerative therapy design for the
Niamh Wilson, Tara Ní Néill, Jake McDonnell, Emily McDonnell, Pieter A. J. Brama, Conor T. Buckley   +5 more
wiley   +1 more source

Mucopolysaccharidoses: A biochemical study under limited resources. [PDF]

Mol Genet Metab Rep
Bouzid F, El Fissi H, Karim K, Sebbar MS, Jabir B, Chuis N, Msanda F, Alif N.   +7 more
europepmc   +1 more source

Peptide and Drug‐Protected Gold Nanoclusters as Promising Biomaterials: Synthesis, Properties, and Applications

Aggregate, Volume 7, Issue 2, February 2026.
The integration of atomically precise gold nanoclusters with peptides or drugs represents a cutting‐edge class of nanomaterials in the biomedical field, owing to their unique physicochemical properties such as water solubility, excellent biocompatibility, low toxicity, and good renal clearance.
Rebeca Garcia Moura, M. Terêsa Machini, Rongchao Jin   +2 more
wiley   +1 more source