Results 91 to 100 of about 64,099 (195)

Osteochondrosis in horses: An overview of genetic and other factors

Equine Veterinary Journal, EarlyView.
Abstract Osteochondrosis (OC) is a frequent manifestation of developmental orthopaedic disease, and its severe clinical presentation is known as OC dissecans (OCD). OC is defined as a disruption of the endochondral ossification process in the epiphyseal cartilage, and this disease has been reported in different mammalian species, including humans, dogs,
Lola Martinez‐Saez, Pablo J. Marín‐García, M. Lola Llobat   +2 more
wiley   +1 more source

Role of chondroitin sulfate proteoglycans (CSPGs) in synaptic plasticity and neurotransmission in mammalian spinal cord. [PDF]

, 2009
Chronic unilateral hemisection (HX) of the adult rat spinal cord diminishes conduction through intact fibers in the ventrolateral funiculus (VLF) contralateral to HX.
Arsen S. Hunanyan, Guillermo Garcia-Alias, James W. Fawcett, Joel M. Levine, Lorne M. Mendell, Victor L. Arvanian   +5 more
core   +1 more source

Classification of Platelet‐Activating Anti‐Platelet Factor 4 Disorders

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The prototypic anti‐platelet factor 4 (PF4) disorder—heparin‐induced thrombocytopenia and thrombosis (HITT)—features immunoglobulin G (IgG) class antibodies that activate platelets, monocytes, and neutrophils in a mainly heparin‐dependent fashion via Fcγ receptor‐dependent cellular activation.
Theodore E. Warkentin
wiley   +1 more source

Neurotrophic extracellular matrix proteins promote neuronal and iPSC astrocyte progenitor cell‐ and nano‐scale process extension for neural repair applications

Journal of Anatomy, Volume 246, Issue 4, Page 585-601, April 2025.
The extracellular matrix plays a critical role in modulating cell behaviour in the central nervous system influencing neural cell morphology and growth. However, a better understanding of the impact of individual matrix proteins on both neurons and astrocytes is critical for advancing the development of matrix‐based neural repair strategies.
Cian O'Connor, Rena E. Mullally, Sarah F. McComish, Julia O'Sullivan, Ian Woods, Ingmar Schoen, Massimiliano Garre, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +9 more
wiley   +1 more source

Heterologous Surface Display Reveals Conserved Complement Inhibition and Functional Diversification of Borrelia burgdorferi Elp Proteins

Molecular Microbiology, EarlyView.
A novel approach using the Pseudomonas syringae ice nucleation protein (INP) system to present Borrelia burgdorferi lipoproteins on the surface of Escherichia coli reveals conservation of complement inhibitory functions among uncharacterized OspE/F‐like leader peptide (Elp) proteins.
Nathan Hill, Lara M. Matulina, Cameron MacIntyre, M. Amine Hassani, Sheila Thomas, Matteo Luban, Isabelle Ward, Amina Abdalla, John M. Leong, Brandon L. Garcia, Jacob E. Lemieux   +10 more
wiley   +1 more source

Electroanalysis and electrophysiological recording of bio‐doped conducting polymer‐modified neural electrodes

Annals of the New York Academy of Sciences, EarlyView.
Neural electrodes were modified with poly(3,4‐ethylenedioxythiophene) (PEDOT) doped with chondroitin sulfate or dextran sulfate. Electrochemical and acute electrophysiological recordings were undertaken. The effective electrode area had the strongest correlation with electrophysiological response.
Alexander R. Harris, Ben J. Allitt, Antonio G. Paolini   +2 more
wiley   +1 more source

Physical activity and joint health: Implications for knee osteoarthritis disease pathophysiology and mechanics

Experimental Physiology, EarlyView.
Abstract Knee osteoarthritis is experienced by hundreds of millions of people worldwide and is a major cause of disability. Although enhancing physical activity levels and the participation in exercise programmes has been proved to improve the debilitating illness of osteoarthritis, many do not engage in recommended levels of physical activity.
Karl Morgan, Joshua Carter, Dario Cazzola, Jean‐Philippe Walhin   +3 more
wiley   +1 more source

Microfluidic Characterization and Analysis of Circulating Tumor Cells From Patients With Metastatic Melanoma

Pigment Cell &Melanoma Research, Volume 38, Issue 4, July 2025.
ABSTRACT Circulating tumor cells (CTCs) can provide non‐invasive insight into how a cancer patient responds to therapy. Their role in disease monitoring of advanced melanoma patients treated with immune checkpoint inhibitors (ICI) is unknown. CTC protein expression of human leukocyte antigen class‐I (HLA I) and programmed death ligand‐1 (PD‐L1) may ...
Matthew C. Mannino, Shuang G. Zhao, Benjamin K. Gibbs, Jennifer L. Schehr, Isabella G. Fernandez, Diego A. Eyzaguirre, Alyssa M. Hintz, Stephanie J. Davis, Manushi N. Vatani, Jacob C. Caceres, Alexander Birbrair, Joshua M. Lang, Vincent T. Ma   +12 more
wiley   +1 more source

Histological Evaluation of Subcutaneous Tissue Reactions to a Novel Bilayer Polycaprolactone/Silk Fibroin/Strontium Carbonate Nanofibrous Membrane for Guided Bone Regeneration: A Study in Rabbits

Clinical and Experimental Dental Research, Volume 11, Issue 3, June 2025.
ABSTRACT Objectives The selection of appropriate biomaterial for guided bone regeneration is challenging. The blending of polymers is a simple method to retain their characteristics and to compensate for the drawbacks of each component. The release of Sr+2 (strontium) ions from the polycaprolactone/strontium carbonate (PCL/SrC) nanocomposite is the ...
Lida Kheiri, Arash Golestaneh, Mehdi Mehdikhani, Sayed Mohammad Razavi, Niloofar Etemadi   +4 more
wiley   +1 more source

Identification of chemically sulfated/desulfated glycosaminoglycans in contaminated heparins and development of a simple assay for the detection of most contaminants in heparin [PDF]

, 2010
Contaminated heparin was linked to at least 149 deaths and hundreds of adverse reactions. Published report indicates that heparin contaminants were a natural impurity, dermatan sulfate, and a contaminant, oversulfated chondroitin sulfate (OSCS). OSCS was
Frazier, Sarah B, Lu, Hong, Pan, Jing, Pazandak, Andrew, Qian, Yi, Weiser, Peter, Zhang, Lijuan, Zhou, Xiaodong   +7 more
core   +1 more source