Results 71 to 80 of about 435,081 (300)

Human Bone‐Derived Endothelial Cells Mediate Bone Regeneration via Distinct Expression of KIT Ligand

Advanced Science, EarlyView.
Bone‐specific endothelial cells (b‐ECs) uniquely express KITLG, which recruits c‐Kit+/CD34+ hematopoietic progenitors (HPCs) to the osteovascular niche, initiating a cascade that culminates in the osteogenic differentiation of bone marrow‐derived mesenchymal stem cells (bm‐MSCs) and subsequent ossification.
Xiang Li, Hwan D. Kim, Allen C. Luo, Liyan Gong, Yonglin Zhu, Chin Nien Lee, Xuechong Hong, Christopher L. Sudduth, Michal Ad, Young‐Hyeon An, Mihn Jeong Park, Do‐Gyoon Kim, Arin K. Greene, Bonnie L. Padwa, Nathaniel S. Hwang, Ruei‐Zeng Lin, Juan M. Melero‐Martin   +16 more
wiley   +1 more source

Effect of diclofenac sodium on the cartilage-regeneration potential of the chitosan-gelatin-chondroitin sulphate scaffold [PDF]

Iraqi Journal of Veterinary Sciences
Osteoarthritis (OA) is a joint disorder that results in decreased chondrocyte function, leading to degradation of the extracellular matrix. Tissue engineering, mainly using scaffolds as implants at the affected joints, has emerged as an effective way to ...
Aniek S. Budiatin, Mutiara P. Pramesti, Wa O. Nurfinti, Yusuf A. Pratama, Dinda M. Ratri, Chrismawan Ardianto   +5 more
doaj   +1 more source

The effect of increasing the sulfation level of chondroitin sulfate on anticoagulant specific activity and activation of the kinin system. [PDF]

PLoS ONE, 2018
Oversulfated chondroitin sulfate (OSCS) was identified as a contaminant in certain heparin preparations as the cause of adverse reactions in patients. OSCS was found to possess both plasma anticoagulant activity and the ability to activate prekallikrein ...
J Hogwood, A Naggi, G Torri, C Page, P Rigsby, B Mulloy, E Gray   +6 more
doaj   +1 more source

A “turn on” fluorescent probe for heparin and its oversulfated chondroitin sulfate contaminant

Chemical Science, 2015
The conjugation of tetraphenylethene and a heparin binding peptide afforded a “turn on” fluorescent probe for reliable determination of heparin and its contaminant oversulfated chondroitin sulfate.
Yubin Ding, Leilei Shi, Hui Wei
semanticscholar   +1 more source

Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity

Advanced Science, EarlyView.
Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi, Claudia Corbo, Julia Enterria‐Rosales, John Otto Martinez, Silvia Minardi, Laura Pandolfi, Xing Wang, Ennio Tasciotti, Kavindra V. Singh, Cesar A. Arias, Bruna Corradetti   +10 more
wiley   +1 more source

Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity

Nanomaterials, 2016
The in situ formation of silver nanoparticles (AgNPs) aided by chondroitin sulfate and the preparation of a hierarchically structured silver-polymer nanocomposite with antimicrobial activity is shown.
María Jesús Hortigüela, Luis Yuste, Fernando Rojo, Inmaculada Aranaz   +3 more
doaj   +1 more source

Establishment and Selection of Indicator Materials for Cervi Parvum Cornu Pharmacopuncture [PDF]

Journal of Acupuncture Research, 2017
Background Recently, Cervi Parvum Cornu pharmacopuncture has been widely used. But no studies on the indicator materials for Cervi Parvum Cornu pharmacopuncture have been conducted.
Kyu-Jin Yang, Ki-Beom Lee, No-Hyeon Kim, Tae-Gyu Kim, Yu-Mi Gi, Hwan-Soo Joo, Chang-Yong Suh, In-Hee Lee, Hwa-Jin Chung, In-Hyuk Ha, Jae-Woong Lee   +10 more
doaj   +1 more source

Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala

Translational Psychiatry, 2015
Perineuronal nets (PNNs) are specialized extracellular matrix aggregates surrounding distinct neuronal populations and regulating synaptic functions and plasticity.
H. Pantazopoulos, M. Markota, F. Jaquet, D. Ghosh, A. Wallin, A. Santos, B. Caterson, S. Berretta   +7 more
semanticscholar   +1 more source

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures

Advanced Science, EarlyView.
This study developed a 3D brain vascular niche model that capture the key features of glioblastoma including perivascular infiltration, gene signature, dormancy and chemo resistance, by comparing 3D model with in vivo condition using identical glioma stem cells.
Vivian K. Lee, Rut Tejero, Nathaniel Silvia, Anirudh Sattiraju, Aarthi Ramakrishnan, Li Shen, Alexandre Wojcinski, Santosh Kesari, Roland H. Friedel, Hongyan Zou, Guohao Dai   +10 more
wiley   +1 more source

Anti‐Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Protein Corona, GP130 Interaction, and Transcriptomic Profile

Advanced Science, EarlyView.
SeNSs provide a biocompatible, anti‐inflammatory UC therapy. SeNSs form protein coronas enriched with AKT/PI3K/NF‐κB pathway proteins, suppress GP130 via hydrophobic interactions, and inhibit pro‐inflammatory cytokines. In DSS‐induced UC mice, SeNSs reduce inflammation, tissue damage, and disease activity by modulating cytokine, chemokine, and ...
Dingyi Shen, Li Gong, Wei Yang, Jiaqi Luo, Zhen Jin, Youzhi Tang   +5 more
wiley   +1 more source