Results 181 to 190 of about 15,622 (209)

FAM20B Gain-of-Function Blocks the Synthesis of Glycosaminoglycan Chains of Proteoglycans and Inhibits Proliferation and Migration of Glioblastoma Cells. [PDF]

Cells
Barré L, Shaukat I, Ouzzine M.
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Neurocan: a brain chondroitin sulfate proteoglycan

Cellular and Molecular Life Sciences, 2001
Neurocan is a chondroitin sulfate proteoglycan of the lectican family and a component of the extracellular matrix of the central nervous system. It is mainly expressed during modeling and remodeling stages of this tissue. Neurocan can bind to various structural extracellular matrix components, such as hyaluronan, heparin, tenascin-C and tenascin-R, and
Xiao-Hong Zhou, Uwe Rauch, K Feng
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Inhibition of Chondroitin Sulfate Proteoglycans by APRIL

2020
Chondroitin sulfate proteoglycans (CSPGs) are major constituents of the extracellular matrix and well-established obstacles to regeneration in the central nervous system. As such, they are promising targets for therapy in neurological pathologies where repair is needed, such as spinal cord injuries, and multiple sclerosis.
Bertrand Huard, Mashal Claude Ahmed
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Biosynthesis of chondroitin sulfate: Microsomal proteoglycans

Biochemical and Biophysical Research Communications, 1978
Abstract A microsomal preparation from chick embryo epiphyseal cartilage was incubated with UDP-[ 14 C]glucuronic acid and UDP-N-acetylgalactosamine to form [ 14 C] chondroitin-labeled proteoglycan. Two [ 14 C]proteoglycan populations were obtained which differed in size, [ 14 C]glycosaminoglycan content, and susceptibility to alkali.
Jeremiah E. Silbert, Jeremiah E. Silbert, Connie R. Faltynek, Connie R. Faltynek   +3 more
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Chondroitin Sulfate Proteoglycans in the Brain

2006
Publisher Summary Chondroitin sulfate proteoglycans (CSPGs) play important roles in the morphogenesis and maintenance of various tissues, including the central nervous system (CNS), through the interactions of their core proteins and/or chondroitin sulfate (CS) chains with cell adhesion molecules, extracellular matrix (ECM) molecules, and growth ...
Sachiko Aono, Atsuhiko Oohira
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Chondroitin Sulfate Proteoglycans in Tumor Progression

2006
Publisher Summary This chapter discusses the implication of stromal and cell surface chondroitin sulfate proteoglycans (CSPGs) to the different aspects of tumor growth and metastasis. In a developing tumor, several CSPGs are overexpressed and deposited into extracellular matrix (ECM) during the stromal reaction. The accumulated PGs participate in the
Wegrowski, Y., F.X., Maquart
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Biosynthetic Precursors of Cartilage Chondroitin Sulfate Proteoglycan

Collagen and Related Research, 1987
Early steps in the biosynthesis of chondroitin sulfate proteoglycan (CSPG) and collagenous cartilage matrix molecules were examined by the comparison of products translated in mRNA-directed cell-free reactions and those synthesized by intact cartilage cells.
Barbara M. Vertel, Youssef Hitti
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The inhibitory effects of chondroitin sulfate proteoglycans on oligodendrocytes

Journal of Neurochemistry, 2011
J. Neurochem. (2011) 119, 176–188.AbstractThe formation of the glial scar following a spinal cord injury presents a significant barrier to the regenerative process. It is primarily composed of chondroitin sulfate proteoglycans (CSPGs) that can inhibit axonal sprouting and regeneration.
Donna J. Osterhout, Justin R. Siebert
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Deglycosylation of chondroitin sulfate proteoglycan and derived peptides

Biochemistry, 1990
In order to define the domain structure of proteoglycans as well as identify primary amino acid sequences specific for attachment of the various carbohydrate substituents, reliable techniques for deglycosylating proteoglycans are required. In this study, deglycosylation of cartilage chondroitin sulfate proteoglycan (CSPG) with minimal core protein ...
Richard C. Krueger, S. C. Campbell, Nancy B. Schwartz   +2 more
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Hydraulic conductivity of chondroitin sulfate proteoglycan solutions

Archives of Biochemistry and Biophysics, 1989
The hydraulic conductivity of solutions of Swarm rat chondrosarcoma proteoglycan subunit and of chondroitin 4- and 6-sulfate up to concentrations of 80 mg ml-1 have been measured under physiological conditions using sedimentation velocity and membrane ultrafiltration techniques.
Wayne D. Comper, Oliver Zamparo
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