Fucosylated Chondroitin Sulfates with Rare Disaccharide Branches from the Sea Cucumbers Psolus peronii and Holothuria nobilis: Structures and Influence on Hematopoiesis [PDF]
Pharmaceuticals, 2023 Two fucosylated chondroitin sulfates were isolated from the sea cucumbers Psolus peronii and Holothuria nobilis using a conventional extraction procedure in the presence of papain, followed by anion-exchange chromatography on DEAE-Sephacel.
Nadezhda E. Ustyuzhanina +12 more
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Low-Molecular-Weight Chondroitin Sulfates Alleviate Simulated Microgravity-Induced Oxidative Stress and Bone Loss in Mice [PDF]
Current Issues in Molecular Biology, 2023 (1) Background: Many studies have shown that microgravity experienced by astronauts or long-term bedridden patients results in increased oxidative stress and bone loss.
Rong Lan +6 more
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Chondroitin Sulfates Control Invasiveness of the Basal-Like Breast Cancer Cell Line MDA-MB-231 Through ROR1 [PDF]
Frontiers in Oncology, 2022 Extracellular and cell surface chondroitin sulfates (CSs) regulate cancer cell properties, including proliferation and invasion. Thus, it is necessary to understand the mechanisms underlying their roles in cancer.
Satomi Nadanaka +2 more
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Holothurian Fucosylated Chondroitin Sulfate [PDF]
Marine Drugs, 2014 Fucosylated chondroitin sulfate (FucCS) is a structurally distinct glycosaminoglycan found in sea cucumber species. It has the same backbone composition of alternating 4-linked glucuronic acid and 3-linked N-acetyl galactosamine residues within ...
Vitor H. Pomin
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Biosynthesis of Chondroitin Sulfate
Journal of Biological Chemistry, 1969 Abstract A microsomal preparation from chick embryo cartilage has been shown to catalyze the incorporation of sulfate-35S from 3'-phosphoadenosine 5'-phosphosulfate-35S into microsomal glycosaminoglycan. This enzyme preparation is the same preparation that previously has been shown to catalyze the formation of chondroitin (nonsulfated) from sugar ...
J E Silbert, S DeLuca
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THE OCCURRENCE OF INTRACELLULAR CHONDROITIN SULFATE [PDF]
The Journal of Cell Biology, 1963 Suspensions of chondrocytes were prepared by treatment with trypsin of the epiphyses of tibias and femurs of 13-day-old chick embryos. After washing to remove the matrix, such suspensions readily incorporate radioactive sulfate into both intracellular and extracellular chondroitin sulfate.
Frank K. Thorp, Albert Dorfman
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Conformational Analysis of the Oligosaccharides Related to Side Chains of Holothurian Fucosylated Chondroitin Sulfates [PDF]
Marine Drugs, 2015 Anionic polysaccharides fucosylated chondroitin sulfates (FCS) from holothurian species were shown to affect various biological processes, such as metastasis, angiogenesis, clot formation, thrombosis, inflammation, and some others.
Alexey G. Gerbst +3 more
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Targeting nanoparticles to lung cancer-derived A549 cells based on changes on interstitial stiffness in biomimetic models [PDF]
iScienceSummary: The mechanical properties and forces of the extracellular environment modulate alveolar epithelial cell behavior. To model cancer/fibrosis associated stiffening and dynamic stretch, a biomimetic device was developed that imitates the active ...
Afia Ibnat Kohon +8 more
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Synthesis of the Oligosaccharides Related to Branching Sites of Fucosylated Chondroitin Sulfates from Sea Cucumbers [PDF]
Marine Drugs, 2015 Natural anionic polysaccharides fucosylated chondroitin sulfates (FCS) from sea cucumbers attract great attention nowadays due to their ability to influence various biological processes, such as blood coagulation, thrombosis, angiogenesis, inflammation ...
Nadezhda E. Ustyuzhanina +4 more
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Engineering of Substrate-Binding Domain to Improve Catalytic Activity of Chondroitin B Lyase with Semi-Rational Design [PDF]
Current Issues in Molecular BiologyDermatan sulfate and chondroitin sulfate are dietary supplements that can be utilized as prophylactics against thrombus formation. Low-molecular-weight dermatan sulfate (LMWDS) is particularly advantageous due to its high absorbability.
Miao Tian +6 more
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