Fucosylated Chondroitin Sulfates with Rare Disaccharide Branches from the Sea Cucumbers Psolus peronii and Holothuria nobilis: Structures and Influence on Hematopoiesis [PDF]
Pharmaceuticals, 2023 Two fucosylated chondroitin sulfates were isolated from the sea cucumbers Psolus peronii and Holothuria nobilis using a conventional extraction procedure in the presence of papain, followed by anion-exchange chromatography on DEAE-Sephacel.
Nadezhda E. Ustyuzhanina +12 more
doaj +2 more sources
Low-Molecular-Weight Chondroitin Sulfates Alleviate Simulated Microgravity-Induced Oxidative Stress and Bone Loss in Mice [PDF]
Current Issues in Molecular Biology, 2023 (1) Background: Many studies have shown that microgravity experienced by astronauts or long-term bedridden patients results in increased oxidative stress and bone loss.
Rong Lan +6 more
doaj +2 more sources
Chondroitin Sulfates Control Invasiveness of the Basal-Like Breast Cancer Cell Line MDA-MB-231 Through ROR1 [PDF]
Frontiers in Oncology, 2022 Extracellular and cell surface chondroitin sulfates (CSs) regulate cancer cell properties, including proliferation and invasion. Thus, it is necessary to understand the mechanisms underlying their roles in cancer.
Satomi Nadanaka +2 more
doaj +2 more sources
Holothurian Fucosylated Chondroitin Sulfate [PDF]
Marine Drugs, 2014 Fucosylated chondroitin sulfate (FucCS) is a structurally distinct glycosaminoglycan found in sea cucumber species. It has the same backbone composition of alternating 4-linked glucuronic acid and 3-linked N-acetyl galactosamine residues within ...
Vitor H. Pomin
doaj +3 more sources
Structural basis for human chondroitin sulfate chain polymerization [PDF]
Nature CommunicationsChondroitin sulfates are complex polysaccharide chains that regulate various biological processes at the cell surface and within the extracellular matrix.
Poushalee Dutta +11 more
doaj +2 more sources
Conformational Analysis of the Oligosaccharides Related to Side Chains of Holothurian Fucosylated Chondroitin Sulfates [PDF]
Marine Drugs, 2015 Anionic polysaccharides fucosylated chondroitin sulfates (FCS) from holothurian species were shown to affect various biological processes, such as metastasis, angiogenesis, clot formation, thrombosis, inflammation, and some others.
Alexey G. Gerbst +3 more
doaj +2 more sources
Synthesis of the Oligosaccharides Related to Branching Sites of Fucosylated Chondroitin Sulfates from Sea Cucumbers [PDF]
Marine Drugs, 2015 Natural anionic polysaccharides fucosylated chondroitin sulfates (FCS) from sea cucumbers attract great attention nowadays due to their ability to influence various biological processes, such as blood coagulation, thrombosis, angiogenesis, inflammation ...
Nadezhda E. Ustyuzhanina +4 more
doaj +2 more sources
Targeting nanoparticles to lung cancer-derived A549 cells based on changes on interstitial stiffness in biomimetic models [PDF]
iScienceSummary: The mechanical properties and forces of the extracellular environment modulate alveolar epithelial cell behavior. To model cancer/fibrosis associated stiffening and dynamic stretch, a biomimetic device was developed that imitates the active ...
Afia Ibnat Kohon +8 more
doaj +2 more sources
Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons [PDF]
Neural Development, 2012 Background Establishing correct neuronal circuitry is crucial to proper function of the vertebrate nervous system. The abundance of chondroitin sulfate (CS) proteoglycans in embryonic neural environments suggests that matrix proteoglycans regulate axonal
Kwok Jessica CF +6 more
doaj +2 more sources
Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc [PDF]
Signal Transduction and Targeted Therapy, 2017 Michelle Kilcoyne +2 more
exaly +2 more sources