Results 21 to 30 of about 10,804 (272)

Chondroitin sulfate metabolism in the brain [PDF]

Acta Neurobiologiae Experimentalis, 2020
Over the last twenty years chondroitin sulfate (CS) has become a focus of interest of neuroscience due to its indubitable role in shaping axonal growth, synaptic plasticity and glial scar forming. Various patterns of sulfation give rise to various CS molecules with different properties that are capable of interactions with a plethora of molecules ...
Anna Katarzyna Greda, D Nowicka
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Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A [PDF]

Carbohydrate Polymers, 2012
Chondroitin sulfate-E (chondroitin-4, 6-disulfate) was prepared from chondroitin sulfate-A (chondroitin-4 - sulfate) by regioselective sulfonation, performed using trimethylamine sulfur trioxide in formamide under argon. The structure of semi-synthetic chondroitin sulfate-E was analyzed by PAGE, (1)H NMR, (13)C NMR, 2D NMR and disaccharide analysis and
Amanda Weyers, Chao Cai, Julie M. Beaudet, Fuming Zhang, Robert J. Linhardt, Kemal Solakyildirim, Bo Yang   +6 more
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Glycosaminoglycans – types, structure, functions, and the role in wound healing processes

Annales Academiae Medicae Silesiensis, 2023
Glycosaminoglycans (GAGs) are a group of heteropolysaccharides, which include: chondroitin sulfates, dermatan sulfates, heparan sulfates, heparin, keratan sulfates, and hyaluronic acid.
Kinga Orlińska, Katarzyna Komosińska-Vassev, Krystyna Olczyk, Aleksandra Kowalczyk, Paweł Olczyk   +4 more
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Retinal Proteoglycans Act as Cellular Receptors for Basement Membrane Assembly to Control Astrocyte Migration and Angiogenesis

Cell Reports, 2016
The basement membrane is crucial for cell polarity, adhesion, and motility, but how it is assembled on the cell surface remains unclear. Here, we find that ablation of glycosaminoglycan (GAG) side chains of proteoglycans in the neuroretina disrupts the ...
Chenqi Tao, Xin Zhang
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Neuroactive Chondroitin Sulfate Glycomimetics [PDF]

Journal of the American Chemical Society, 2008
We report the generation of chondroitin sulfate (CS) glycomimetics with tunable chemical and biological properties. Our approach greatly simplifies the synthesis of complex glycosaminoglycans, providing synthetically accessible, bioactive structures of programmable sulfation sequence.
Rawat, Manish, Gama, Cristal I., Matson, John B., Hsieh-Wilson, Linda C.   +3 more
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The effect of increasing the sulfation level of chondroitin sulfate on anticoagulant specific activity and activation of the kinin system. [PDF]

PLoS ONE, 2018
Oversulfated chondroitin sulfate (OSCS) was identified as a contaminant in certain heparin preparations as the cause of adverse reactions in patients. OSCS was found to possess both plasma anticoagulant activity and the ability to activate prekallikrein ...
J Hogwood, A Naggi, G Torri, C Page, P Rigsby, B Mulloy, E Gray   +6 more
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Peculiarities of the structural and functional state of bone tissue in children during the second growth spurt

Bolʹ, Sustavy, Pozvonočnik, 2022
Background. Bone health is relevant for patients of all age groups. Special attention is paid to childhood and adolescence, since it is during this period that bone mass is actively accumulated, which depends on the structural and functional state of the
T.V. Frolova, N.S. Osman, N.F. Stenkova, I.I. Tereshchenkova, I.R. Siniaieva, A.V. Senatorova, A.H. Amash   +6 more
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Modulation of inflammation by chondroitin sulfate [PDF]

Osteoarthritis and Cartilage, 2010
To evaluate the immune-modulator effect of chondroitin sulfate (CS) by means of the review of the literature.Inflammatory reactions are primarily originated by infectious agents, immune reactions and by sterile tissue lesions that activate membrane receptors by means of pathogen-associated molecular patterns, tissue breakdown products and cytokines ...
P. du Souich, M. Vallières
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Evaluation of an Amniotic Membrane-Collagen Dermal Substitute in the Management of Full-Thickness Skin Defects in a Pig [PDF]

Archives of Plastic Surgery, 2013
BackgroundTo minimize the inflammatory reaction and improve healing, a new modified dermal substitute composed of an atelocollagen, chondroitin-6-sulfate, and amniotic membrane (AM) was applied to full-thickness skin defects in a pig.
Hyunji Kim, Daegu Son, Tae Hyun Choi, Samhyun Jung, Sunyoung Kwon, Junhyung Kim, Kihwan Han   +6 more
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Effect of glycosaminoglycans on the structure and composition of articular cartilage and bone of broilers

Poultry Science, 2023
: This study aimed to assess the influence of glycosaminoglycan (chondroitin and glucosamine sulfates) supplementation in the diet of broilers on the expression of matrix metallopeptidase 9 (MMP-9) and metallopeptidase inhibitor 2 (TIMP-2) genes, the ...
Julyana M.S. Martins, Lindolfo D. dos Santos Neto, Sarah Sgavioli, Itallo C.S. Araújo, Angela A.S. Reis, Rodrigo S. Santos, Eugênio G. de Araújo, Nadja S.M. Leandro, Marcos B. Café   +8 more
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