Results 51 to 60 of about 38,056 (264)
Mutant IDH1 Depletion Downregulates Integrins and Impairs Chondrosarcoma Growth
Cancers, 2020 Chondrosarcomas are a heterogeneous group of malignant bone tumors that produce hyaline cartilaginous matrix. Mutations in isocitrate dehydrogenase enzymes (IDH1/2) were recently described in several cancers, including conventional and dedifferentiated ...
Luyuan Li +12 more
semanticscholar +1 more source
Laryngeal Chondrosarcoma [PDF]
Head and Neck Pathology, 2013 Laryngeal chondrosarcoma is a rare tumor requiring clinical, histologic, and radiographic correlation for definitive diagnosis. Although it typically presents with low-grade histology, even high-grade histology has a fairly indolent progression in this location, with a relatively low-likelihood for metastatic potential or recurrence.
Evelyn M. Potochny, Aaron R Huber
openaire +3 more sources
Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications
Advanced Science, EarlyView.HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang +5 more
wiley +1 more source
Cell Death and Disease, 2019 Resistin is an adipokine that is associated with obesity, inflammation, and various cancers. Chondrosarcomas are primary malignant bone tumors that have a poor prognosis.
Shiou-Sheng Chen +11 more
semanticscholar +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Hereditary multiple osteochondromas (HMO) is an autosomal dominant disorder caused by heterozygous deleterious variants in the EXT1 or EXT2 genes. While the clinical core phenotype is well established and mainly consists of bone deformities, limb length discrepancies, multiple benign bone neoplasms, and increased risk of chondrosarcoma, the ...
Francesco Comisi +7 more
wiley +1 more source
Scientific Reports, 2017 Chondrosarcoma is a malignant primary bone tumor. Sirtuin-1 (SIRT1), which is a member of sirtuin family, plays a dual role either in cancer promotion or suppression.
Sung-Chuan Chao +9 more
doaj +1 more source
Head &Neck, EarlyView.ABSTRACT Introduction The past two decades have seen a paradigm shift in the surgical treatment of sinonasal malignancies, moving from traditional open approaches to minimally invasive endoscopic techniques. Technological advancements have enabled the use of the endoscopic endonasal transcribriform approach (EETA) for tumors involving the anterior ...
Michel Khalaf +11 more
wiley +1 more source
Lymph node metastasis in extremity chondrosarcomas
South Asian Journal of Cancer, 2020 Bacground: Primary bone sarcomas mainly metastasize through haematogenous route and rarely through lymph nodes due to paucity of lymphatic channels in the bone (1).
Vineet Kurisunkal +3 more
doaj +1 more source
Nanotechnology in brain cancer treatment: The role of gold nanoparticles as therapeutic enhancers
Ibrain, EarlyView.This review highlights the potential of gold nanoparticles (AuNPs) in overcoming the blood‐brain barrier (BBB) to improve brain tumor treatment. By enabling targeted drug delivery and enhancing therapies like radiotherapy, phototherapy, and chemotherapy, AuNPs offer a promising approach for safer, more effective treatments of glioblastoma and other ...
Simona Tarantino +4 more
wiley +1 more source
Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis
Diagnostic Pathology, 2012 Purpose To investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.
Liang Xiaohui +5 more
doaj +1 more source