Results 1 to 10 of about 19,276 (249)
CD3L1 expression and its association with the tumor microenvironment in 62 cases of osteosarcoma and Chordoma [PDF]
Scientific ReportsCD3L1 (ITPRIPL1), a natural ligand of CD3ε, is implicated in tumor-immune interactions and is overexpressed in several solid tumors. However, its expression and functional significance in osteosarcoma and chordoma remain uncharacterized. This study aimed
Yuhang Wang +8 more
doaj +4 more sources
DEPDC1B regulates the progression of human chordoma through UBE2T-mediated ubiquitination of BIRC5 [PDF]
Cell Death and Disease, 2021 Chordoma is a rare bone malignancy with a high rate of local recurrence and distant metastasis. Although DEP domain-containing protein 1B (DEPDC1B) is implicated in a variety of malignancies, its relationship with chordoma is unclear.
Liang Wang +8 more
doaj +2 more sources
The driver landscape of sporadic chordoma [PDF]
Nature Communications, 2017 Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations
Patrick S. Tarpey +31 more
doaj +6 more sources
Human eosinophils exert antitumorigenic effects on chordoma [PDF]
Chinese Neurosurgical JournalBackground Chordoma is a devastating rare tumor with a poor prognosis, limited therapeutic options and a high recurrence rate. The exploration of novel therapeutic targets has important clinical significance in chordoma diagnosis, treatment, and outcome ...
Wang Ying +6 more
doaj +2 more sources
Arquivos de Neuro-Psiquiatria, 2008 Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Hospital São PauloUNIFESP, EPM, Hospital São ...
Bonatelli, Antonio de Pádua Furquim +2 more
core +5 more sources
Ubiquitin-independent pathway regulates the RIT1-MAPK pathway in chordoma progression [PDF]
Cell Death and DiseaseChordoma is a rare, slow-growing malignant tumor originating from embryonic notochord remnants and is often found in the sacrum or skull base. It is categorized into conventional, poorly differentiated, and dedifferentiated types, with the conventional ...
Hui Chen +10 more
doaj +2 more sources
N6‐methyladenosine‐modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis [PDF]
Clinical and Translational MedicineBackground Chordoma, a rare bone tumour with aggressive local invasion and high recurrence rate with limited understanding of its molecular mechanisms. Circular RNAs (circRNAs) have been extensively implicated in tumorigenesis, yet their involvement in ...
Hanwen Li +9 more
doaj +2 more sources
Archives of Pathology & Laboratory Medicine, 2021 Context.— Chordomas are uncommon malignant neoplasms with notochordal differentiation encountered by neuropathologists, bone/soft tissue pathologists, and general surgical pathologists. These lesions most commonly arise in the axial skeleton.
Veronica, Ulici, Jesse, Hart
openaire +2 more sources
Journal for ImmunoTherapy of Cancer, 2023 Background Chordoma is an extremely rare, locally aggressive malignant bone tumor originating from undifferentiated embryonic remnants. There are no effective therapeutic strategies for chordoma.
Wei Wang +14 more
doaj +1 more source