Results 1 to 10 of about 7,206 (161)

CHI3L1 Expression in Chordoma: Implications for Immunotherapeutic Intervention [PDF]

Cells
Chordomas are rare, highly morbid tumors arising from notochordal progenitor cells along the spinal axis, associated with severe neurological complications and high recurrence rates.
Beatrice Campilan, Christian Godinez, Jonathan Arditi, Jessica Ding, Kaylee Gallagher, Andrew Fogarty, Christian Schroeder, Madison J. Michles, Weston de Lomba, Joselynn Wallace, John Santiago, Michael Punsoni, Suchitra Kamle, Jack A. Elias, Christine Lee, Ziya L. Gokaslan, Margot Martinez-Moreno, Patricia L. Zadnik Sullivan   +17 more
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Human eosinophils exert antitumorigenic effects on chordoma [PDF]

Chinese Neurosurgical Journal
Background Chordoma is a devastating rare tumor with a poor prognosis, limited therapeutic options and a high recurrence rate. The exploration of novel therapeutic targets has important clinical significance in chordoma diagnosis, treatment, and outcome ...
Wang Ying, Li Peng, Bai Jingqiao, Xu Lingzhi, Ren Yuan, Liu Pinan, Wang Bo   +6 more
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Ubiquitin-independent pathway regulates the RIT1-MAPK pathway in chordoma progression [PDF]

Cell Death and Disease
Chordoma is a rare, slow-growing malignant tumor originating from embryonic notochord remnants and is often found in the sacrum or skull base. It is categorized into conventional, poorly differentiated, and dedifferentiated types, with the conventional ...
Hui Chen, Qiujing Guan, Cheng Yang, Yang Chen, Yan Liu, Wenjie Ren, Su Chen, Lei Li, Dongxia Li, Jianguo Tang, Nanzhe Zhong   +10 more
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CD3L1 expression and its association with the tumor microenvironment in 62 cases of osteosarcoma and Chordoma [PDF]

Scientific Reports
CD3L1 (ITPRIPL1), a natural ligand of CD3ε, is implicated in tumor-immune interactions and is overexpressed in several solid tumors. However, its expression and functional significance in osteosarcoma and chordoma remain uncharacterized. This study aimed
Yuhang Wang, Jiuhui Xu, Shouyan Deng, Kunkun Sun, Yaqi Wang, Tingting Ren, Xiaodong Tang, Jie Xu, Lu Xie   +8 more
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Chordoma [PDF]

Archives of Pathology & Laboratory Medicine, 2021
Context.— Chordomas are uncommon malignant neoplasms with notochordal differentiation encountered by neuropathologists, bone/soft tissue pathologists, and general surgical pathologists. These lesions most commonly arise in the axial skeleton.
Veronica, Ulici, Jesse, Hart
openaire   +2 more sources

Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression

Journal for ImmunoTherapy of Cancer, 2023
Background Chordoma is an extremely rare, locally aggressive malignant bone tumor originating from undifferentiated embryonic remnants. There are no effective therapeutic strategies for chordoma.
Wei Wang, Wei Guo, Yu Zhu, Yi Huang, Tingting Ren, Xiaodong Tang, Lei Guo, Jiuhui Xu, Qianyu Shi, Jingbing Lou, Boyang Wang, Jianfang Niu, Chenglong Chen, Yiyang Yu, Jianqiang Lan   +14 more
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Mapping the landscape of genetic dependencies in chordoma

Nature Communications, 2023
Cancer cells possess unique molecular features that can confer an increased dependence on specific genes. Here, the authors use CRISPR-Cas9 screens to identify selectively essential genes and therapeutic targets in chordoma.
Tanaz Sharifnia, Mathias J. Wawer, Amy Goodale, Yenarae Lee, Mariya Kazachkova, Joshua M. Dempster, Sandrine Muller, Joan Levy, Daniel M. Freed, Josh Sommer, Jérémie Kalfon, Francisca Vazquez, William C. Hahn, David E. Root, Paul A. Clemons, Stuart L. Schreiber   +15 more
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Activity of pemetrexed in pre-clinical chordoma models and humans

Scientific Reports, 2023
Chordomas are rare slow growing tumors, arising from embryonic remnants of notochord with a close predilection for the axial skeleton. Recurrence is common and no effective standard medical therapy exists.
Santosh Kesari, Feng Wang, Tiffany Juarez, Shashaanka Ashili, C. Pawan K. Patro, Jose Carrillo, Minhdan Nguyen, Judy Truong, Joan Levy, Josh Sommer, Daniel M. Freed, Joanne Xiu, Yuki Takasumi, Eric Bouffet, Jaya M. Gill   +14 more
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PALB2 as a factor to predict the prognosis of patients with skull base chordoma

Frontiers in Oncology, 2022
ObjectiveThis study aimed to study the role of PALB2 on the prognosis of skull base chordoma patients and the proliferation, migration, and invasion of chordoma cells.
Yujia Xiong, Mingxuan Li, Yutao Shen, Tianshun Ma, Jiwei Bai, Yazhuo Zhang, Yazhuo Zhang, Yazhuo Zhang, Yazhuo Zhang   +8 more
doaj   +1 more source

Epidemiologic trend of mobile spine and sacrum chordoma: A National population-based study

Journal of Craniovertebral Junction and Spine, 2020
Introduction: Chordoma is a rare sarcoma of the axial skeleton. The incidence of this tumor is different between races. To understand the epidemiologic characteristic and due to rarity of this pathology, large number of cases should be evaluated through ...
Mohammadreza Chehrassan, Adel Ebrahimpour, Mehrdad Sadighi, Mehdi Azizmohammad Looha, Saber Barazandeh Rad, Mohammad Esmaeil Akbari   +5 more
doaj   +1 more source