Results 1 to 10 of about 19,107 (247)

Epidemiologic trend of mobile spine and sacrum chordoma: A National population-based study

Journal of Craniovertebral Junction and Spine, 2020
Introduction: Chordoma is a rare sarcoma of the axial skeleton. The incidence of this tumor is different between races. To understand the epidemiologic characteristic and due to rarity of this pathology, large number of cases should be evaluated through ...
Mohammadreza Chehrassan, Adel Ebrahimpour, Mehrdad Sadighi, Mehdi Azizmohammad Looha, Saber Barazandeh Rad, Mohammad Esmaeil Akbari   +5 more
doaj   +2 more sources

Human eosinophils exert antitumorigenic effects on chordoma [PDF]

Chinese Neurosurgical Journal
Background Chordoma is a devastating rare tumor with a poor prognosis, limited therapeutic options and a high recurrence rate. The exploration of novel therapeutic targets has important clinical significance in chordoma diagnosis, treatment, and outcome ...
Wang Ying, Li Peng, Bai Jingqiao, Xu Lingzhi, Ren Yuan, Liu Pinan, Wang Bo   +6 more
doaj   +2 more sources

Ubiquitin-independent pathway regulates the RIT1-MAPK pathway in chordoma progression [PDF]

Cell Death and Disease
Chordoma is a rare, slow-growing malignant tumor originating from embryonic notochord remnants and is often found in the sacrum or skull base. It is categorized into conventional, poorly differentiated, and dedifferentiated types, with the conventional ...
Hui Chen, Qiujing Guan, Cheng Yang, Yang Chen, Yan Liu, Wenjie Ren, Su Chen, Lei Li, Dongxia Li, Jianguo Tang, Nanzhe Zhong   +10 more
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CD3L1 expression and its association with the tumor microenvironment in 62 cases of osteosarcoma and Chordoma [PDF]

Scientific Reports
CD3L1 (ITPRIPL1), a natural ligand of CD3ε, is implicated in tumor-immune interactions and is overexpressed in several solid tumors. However, its expression and functional significance in osteosarcoma and chordoma remain uncharacterized. This study aimed
Yuhang Wang, Jiuhui Xu, Shouyan Deng, Kunkun Sun, Yaqi Wang, Tingting Ren, Xiaodong Tang, Jie Xu, Lu Xie   +8 more
doaj   +2 more sources

Recurrent Nasopharyngeal Chordoma Stabilized With Afatinib: A Case Report [PDF]

Cureus
Chen C, Yeung V.
europepmc   +3 more sources

RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy [PDF]

Advanced Science
Chordoma, a rare mesenchymal malignancy, exhibits a high tendency to postoperative recurrence and poor prognosis. To date, its tumorigenic regulatory mechanisms remain elusive, leading to a lack of effective therapeutic targets and drug sensitivity ...
Jianxuan Gao, Jiali Jin, Runzhi Huang, Siqiao Wang, Sihui Song, Yu Zhang, Yongai Li, Jun Lin, Zhengyan Chang, Zongqiang Huang, Wei Sun, Huabin Yin, Dianwen Song, Jianru Xiao, Ping Wang, Tong Meng   +15 more
doaj   +2 more sources

Identification of immune subtypes associated with the prognosis in skull base chordoma [PDF]

Acta Neuropathologica Communications
Chordoma is a rare malignant bone tumor that is prone to local recurrence. Recent omics studies suggest that chordoma is a heterogenous disease and the tumor immune microenvironment (TIME) may be associated with chordoma recurrence and patient survival ...
Yujia Xiong, Mingxuan Li, Guangyi Niu, Tianyi Xu, Chuzhong Li, Tianshun Ma, Tianhao Zhang, Hela Koka, Lili Hao, Yazhuo Zhang, Jiwei Bai, Xiaohong R. Yang   +11 more
doaj   +2 more sources

Development and validation of basement membrane-related signatures for predicting postoperative recurrence, tumor microenvironment and drug candidates in chordomas [PDF]

BMC Cancer
Background Skull base chordoma is a rare and aggressive bone tumor with a poor prognosis. The basement membrane (BM) plays an pivotal role in tumor progression.
Tianhao Zhang, Mingxuan Li, Xing Liu, Sida Zhao, Tianshun Ma, Yide Liu, Xijia Zhang, Qian Liu, Jiwei Bai, Yazhuo Zhang   +9 more
doaj   +2 more sources

Chordoma recruits and polarizes tumor-associated macrophages via secreting CCL5 to promote malignant progression

Journal for ImmunoTherapy of Cancer, 2023
Background Chordoma is an extremely rare, locally aggressive malignant bone tumor originating from undifferentiated embryonic remnants. There are no effective therapeutic strategies for chordoma.
Wei Wang, Wei Guo, Yu Zhu, Yi Huang, Tingting Ren, Xiaodong Tang, Lei Guo, Jiuhui Xu, Qianyu Shi, Jingbing Lou, Boyang Wang, Jianfang Niu, Chenglong Chen, Yiyang Yu, Jianqiang Lan   +14 more
doaj   +1 more source

Mapping the landscape of genetic dependencies in chordoma

Nature Communications, 2023
Cancer cells possess unique molecular features that can confer an increased dependence on specific genes. Here, the authors use CRISPR-Cas9 screens to identify selectively essential genes and therapeutic targets in chordoma.
Tanaz Sharifnia, Mathias J. Wawer, Amy Goodale, Yenarae Lee, Mariya Kazachkova, Joshua M. Dempster, Sandrine Muller, Joan Levy, Daniel M. Freed, Josh Sommer, Jérémie Kalfon, Francisca Vazquez, William C. Hahn, David E. Root, Paul A. Clemons, Stuart L. Schreiber   +15 more
doaj   +1 more source