Results 11 to 20 of about 19,276 (249)

Mapping the landscape of genetic dependencies in chordoma

Nature Communications, 2023
Cancer cells possess unique molecular features that can confer an increased dependence on specific genes. Here, the authors use CRISPR-Cas9 screens to identify selectively essential genes and therapeutic targets in chordoma.
Tanaz Sharifnia, Mathias J. Wawer, Amy Goodale, Yenarae Lee, Mariya Kazachkova, Joshua M. Dempster, Sandrine Muller, Joan Levy, Daniel M. Freed, Josh Sommer, Jérémie Kalfon, Francisca Vazquez, William C. Hahn, David E. Root, Paul A. Clemons, Stuart L. Schreiber   +15 more
doaj   +1 more source

Proton beam therapy in paediatric cancer: Anticipating the opening of the Australian Bragg Centre for Proton Therapy and Research

Journal of Medical Imaging and Radiation Oncology, EarlyView., 2023
Summary Proton Beam Therapy (PBT) has the potential to improve paediatric cancer care by reducing radiation exposure and thus long‐term toxicities. Ethical concerns and debates surrounding the treatment, such as eligibility and accessibility, are ongoing in Australia. The Australian Bragg Centre for Proton Therapy and Research (ABCPTR) (named after Sir
Jeremy Khong, Hui Tee, Peter Gorayski, Hien Le, Michael Penniment, Sophie Jessop, Jordan Hansford, Melanie Penfold, Julia Green, Kelly Skelton, Frank Saran   +10 more
wiley   +1 more source

Activity of pemetrexed in pre-clinical chordoma models and humans

Scientific Reports, 2023
Chordomas are rare slow growing tumors, arising from embryonic remnants of notochord with a close predilection for the axial skeleton. Recurrence is common and no effective standard medical therapy exists.
Santosh Kesari, Feng Wang, Tiffany Juarez, Shashaanka Ashili, C. Pawan K. Patro, Jose Carrillo, Minhdan Nguyen, Judy Truong, Joan Levy, Josh Sommer, Daniel M. Freed, Joanne Xiu, Yuki Takasumi, Eric Bouffet, Jaya M. Gill   +14 more
doaj   +1 more source

PALB2 as a factor to predict the prognosis of patients with skull base chordoma

Frontiers in Oncology, 2022
ObjectiveThis study aimed to study the role of PALB2 on the prognosis of skull base chordoma patients and the proliferation, migration, and invasion of chordoma cells.
Yujia Xiong, Mingxuan Li, Yutao Shen, Tianshun Ma, Jiwei Bai, Yazhuo Zhang, Yazhuo Zhang, Yazhuo Zhang, Yazhuo Zhang   +8 more
doaj   +1 more source

Recurrent Chromosomal Copy Number Alterations in Sporadic Chordomas [PDF]

, 2011
The molecular events in chordoma pathogenesis have not been fully delineated, particularly with respect to copy number changes. Understanding copy number alterations in chordoma may reveal critical disease mechanisms that could be exploited for tumor ...
A Kuźniacka, A McCabe, A. John Iafrate, AAE Shalaby, Andrew Eric Rosenberg, D Dias-Santagata, Dafydd Thomas, F Bayrakli, Francis J. Hornicek, G. Petur Nielsen, GJ Oakley, H Hof, J Sommer, JG Herman, Joseph Schwab, Julie M. Batten, KH Hallor, L Dalprà, L Lee-Jones, Long Phi Le, LSH Chuang, M Miozzo, MA Zysman, MB Eisenberg, MJ Heffelfinger, MJ Kelley, N Presneau, P Riva, PG Casali, PJ Stephens, PM Weinberger, R Pallini, R Tirabosco, Ramnik J. Xavier, S Everhard, S Han, S Scheil, S Stacchiotti, Syed A. Aziz, T Naka, Vikram Deshpande, WY Kim, XR Yang, Zhenfeng Duan   +43 more
core   +11 more sources

Epidemiologic trend of mobile spine and sacrum chordoma: A National population-based study

Journal of Craniovertebral Junction and Spine, 2020
Introduction: Chordoma is a rare sarcoma of the axial skeleton. The incidence of this tumor is different between races. To understand the epidemiologic characteristic and due to rarity of this pathology, large number of cases should be evaluated through ...
Mohammadreza Chehrassan, Adel Ebrahimpour, Mehrdad Sadighi, Mehdi Azizmohammad Looha, Saber Barazandeh Rad, Mohammad Esmaeil Akbari   +5 more
doaj   +1 more source

Prognostic Significance of Cyclin E1 Expression in Patients With Chordoma: A Clinicopathological and Immunohistochemical Study

Frontiers in Oncology, 2020
PurposeChordomas are rare, slow-growing sarcomas without any accepted prognostic biomarkers. Owing to their proximity to critical neurovascular structures, discovering predictive biomarkers in chordoma has been a significant research effort because it ...
Ran Wei, Ran Wei, Dylan C. Dean, Pichaya Thanindratarn, Pichaya Thanindratarn, Francis J. Hornicek, Wei Guo, Zhenfeng Duan   +7 more
doaj   +1 more source

Gluteus maximus metastasis from sacrococcygeal chordoma: A case report

Radiology Case Reports, 2022
We reported the metastatic chordoma in the right gluteus maximus of a 73-year-old man. The patient was initially diagnosed with sacrococcygeal chordoma and treated with surgical resection.
Wanchen Liu, MD, Xiao Xu, MD, Zhongsheng Zhang, MD, Jian Sun, MD, Heng Ma, MD   +4 more
doaj   +1 more source

Research hotspots and trends of chordoma: A bibliometric analysis

Frontiers in Oncology, 2022
BackgroundChordoma is a type of mesenchymal malignancy with a high recurrence rate and poor prognosis. Due to its rarity, the tumorigenic mechanism and optimal therapeutic strategy are not well known.MethodsAll relevant articles of chordoma research from
Jianxuan Gao, Jianxuan Gao, Runzhi Huang, Huabin Yin, Dianwen Song, Tong Meng, Tong Meng   +6 more
doaj   +1 more source

Bibliometric analysis of the global research trends and hotspots in chordoma from 2000 to 2020

PLoS ONE, 2022
Introduction Chordoma is formed from embryonic residues or ectopic chordae and locally aggressive or malignant tumors. We visually analyzed the research tendency and hotspot of chordoma.
Cuicui Chang, Kai Tang, Yifan Gao, Jingyao Dai, Chen Dai   +4 more
doaj   +3 more sources