Results 11 to 20 of about 7,206 (161)

Matrix Metalloproteinase-13 Is an Unfavorable Prognostic Factor in Chordoma by Digesting Growth Inhibitory Collagens. [PDF]

Cancer Med
ABSTRACT Objective Chordomas are low‐grade but invasive tumors with limited therapies. Some conventional chordomas exhibit cartilage‐like extracellular matrix (ECM). This study examined the expression and clinical significance of collagenases in chordomas.
Oishi Y, Kawaai K, Tamura R, Kuroda Y, Noji S, Toda M, Matsuo K.   +6 more
europepmc   +2 more sources

Proton beam therapy in paediatric cancer: Anticipating the opening of the Australian Bragg Centre for Proton Therapy and Research

Journal of Medical Imaging and Radiation Oncology, EarlyView., 2023
Summary Proton Beam Therapy (PBT) has the potential to improve paediatric cancer care by reducing radiation exposure and thus long‐term toxicities. Ethical concerns and debates surrounding the treatment, such as eligibility and accessibility, are ongoing in Australia. The Australian Bragg Centre for Proton Therapy and Research (ABCPTR) (named after Sir
Jeremy Khong, Hui Tee, Peter Gorayski, Hien Le, Michael Penniment, Sophie Jessop, Jordan Hansford, Melanie Penfold, Julia Green, Kelly Skelton, Frank Saran   +10 more
wiley   +1 more source

DEPDC1B regulates the progression of human chordoma through UBE2T-mediated ubiquitination of BIRC5

Cell Death and Disease, 2021
Chordoma is a rare bone malignancy with a high rate of local recurrence and distant metastasis. Although DEP domain-containing protein 1B (DEPDC1B) is implicated in a variety of malignancies, its relationship with chordoma is unclear.
Liang Wang, Liang Tang, Ruijun Xu, Junpeng Ma, Kaibing Tian, Yanbin Liu, Yanghu Lu, Zhen Wu, Xiaodong Zhu   +8 more
doaj   +1 more source

Gluteus maximus metastasis from sacrococcygeal chordoma: A case report

Radiology Case Reports, 2022
We reported the metastatic chordoma in the right gluteus maximus of a 73-year-old man. The patient was initially diagnosed with sacrococcygeal chordoma and treated with surgical resection.
Wanchen Liu, MD, Xiao Xu, MD, Zhongsheng Zhang, MD, Jian Sun, MD, Heng Ma, MD   +4 more
doaj   +1 more source

Prognostic Significance of Cyclin E1 Expression in Patients With Chordoma: A Clinicopathological and Immunohistochemical Study

Frontiers in Oncology, 2020
PurposeChordomas are rare, slow-growing sarcomas without any accepted prognostic biomarkers. Owing to their proximity to critical neurovascular structures, discovering predictive biomarkers in chordoma has been a significant research effort because it ...
Ran Wei, Ran Wei, Dylan C. Dean, Pichaya Thanindratarn, Pichaya Thanindratarn, Francis J. Hornicek, Wei Guo, Zhenfeng Duan   +7 more
doaj   +1 more source

Research hotspots and trends of chordoma: A bibliometric analysis

Frontiers in Oncology, 2022
BackgroundChordoma is a type of mesenchymal malignancy with a high recurrence rate and poor prognosis. Due to its rarity, the tumorigenic mechanism and optimal therapeutic strategy are not well known.MethodsAll relevant articles of chordoma research from
Jianxuan Gao, Jianxuan Gao, Runzhi Huang, Huabin Yin, Dianwen Song, Tong Meng, Tong Meng   +6 more
doaj   +1 more source

LncRNA NONHSAT114552 Sponges miR-320d to Promote Proliferation and Invasion of Chordoma Through Upregulating NRP1

Frontiers in Pharmacology, 2021
Chordoma is a relatively rare malignant bone tumor with high local recurrence. To date, the mechanism remains unclear. lncRNAs play a pivotal role in tumorigenesis by acting as competitive endogenous RNAs of microRNAs.
Kai Zhang, Zixiang Liu, Yingchuang Tang, Xiaofeng Shao, Xi Hua, Hao Liu, Huilin Yang, Kangwu Chen   +7 more
doaj   +1 more source

Bibliometric analysis of the global research trends and hotspots in chordoma from 2000 to 2020

PLoS ONE, 2022
Introduction Chordoma is formed from embryonic residues or ectopic chordae and locally aggressive or malignant tumors. We visually analyzed the research tendency and hotspot of chordoma.
Cuicui Chang, Kai Tang, Yifan Gao, Jingyao Dai, Chen Dai   +4 more
doaj   +3 more sources

Research Advances in Molecular Regulatory Mechanism of Chordoma

Zhongliu Fangzhi Yanjiu, 2019
Chordoma is a rare primary malignant bone tumor derived from notochord remnants. Due to its strong local invasiveness and chemotherapy resistance, chordoma has a high local recurrence rate and poor prognosis.
LIANG Chen, YANG Chenlong, LIU Xiaoguang
doaj   +1 more source

Dedifferentiated chordoma, a case report

Journal of Pathology of Nepal, 2022
Dedifferentiated chordoma is a rare variant of chordoma, exhibiting simultaneous presence of  conventional chordoma and component of high grade sarcoma. It occurs either de novo or in the form of high grade transformation of a conventional chordoma in a ...
Girishma Shrestha, Paromita Roy, Indu Arun, Argha Chatterjee, Gautam Biswas   +4 more
doaj   +1 more source