Results 11 to 20 of about 19,107 (247)
Arquivos de Neuro-Psiquiatria, 2008 Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Hospital São PauloUNIFESP, EPM, Hospital São ...
Rita Delgado +2 more
core +7 more sources
The driver landscape of sporadic chordoma [PDF]
Nature Communications, 2017 Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations
Patrick S. Tarpey +31 more
doaj +6 more sources
Archives of Pathology & Laboratory Medicine, 2021 Context.— Chordomas are uncommon malignant neoplasms with notochordal differentiation encountered by neuropathologists, bone/soft tissue pathologists, and general surgical pathologists. These lesions most commonly arise in the axial skeleton.
Veronica, Ulici, Jesse, Hart
openaire +2 more sources
Journal of Medical Imaging and Radiation Oncology, EarlyView., 2023 Summary Proton Beam Therapy (PBT) has the potential to improve paediatric cancer care by reducing radiation exposure and thus long‐term toxicities. Ethical concerns and debates surrounding the treatment, such as eligibility and accessibility, are ongoing in Australia. The Australian Bragg Centre for Proton Therapy and Research (ABCPTR) (named after Sir
Jeremy Khong +10 more
wiley +1 more source
PALB2 as a factor to predict the prognosis of patients with skull base chordoma
Frontiers in Oncology, 2022 ObjectiveThis study aimed to study the role of PALB2 on the prognosis of skull base chordoma patients and the proliferation, migration, and invasion of chordoma cells.
Yujia Xiong +8 more
doaj +1 more source
Activity of pemetrexed in pre-clinical chordoma models and humans
Scientific Reports, 2023 Chordomas are rare slow growing tumors, arising from embryonic remnants of notochord with a close predilection for the axial skeleton. Recurrence is common and no effective standard medical therapy exists.
Santosh Kesari +14 more
doaj +1 more source
DEPDC1B regulates the progression of human chordoma through UBE2T-mediated ubiquitination of BIRC5
Cell Death and Disease, 2021 Chordoma is a rare bone malignancy with a high rate of local recurrence and distant metastasis. Although DEP domain-containing protein 1B (DEPDC1B) is implicated in a variety of malignancies, its relationship with chordoma is unclear.
Liang Wang +8 more
doaj +1 more source
Gluteus maximus metastasis from sacrococcygeal chordoma: A case report
Radiology Case Reports, 2022 We reported the metastatic chordoma in the right gluteus maximus of a 73-year-old man. The patient was initially diagnosed with sacrococcygeal chordoma and treated with surgical resection.
Wanchen Liu, MD +4 more
doaj +1 more source
A Rare Chordoma-The Epiglottic chordoma
Ear, Nose & Throat Journal, 2022 Chordomas are rare malignant bone tumors. Chordomas originate from notochordal elements. Chordomas have the phenotype of the embryonic notochord, characterized by the dual expression of cytokeratin and brachyury. Chordomas occur anywhere along the central axis. Rarely, chordomas occur in extra-axial structures.
Jinfen Yu +4 more
openaire +2 more sources
Frontiers in Oncology, 2020 PurposeChordomas are rare, slow-growing sarcomas without any accepted prognostic biomarkers. Owing to their proximity to critical neurovascular structures, discovering predictive biomarkers in chordoma has been a significant research effort because it ...
Ran Wei +7 more
doaj +1 more source