Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR [PDF]
, 2016 Chordomas are rare primary malignant bone tumors arising from embryonal notochord remnants of the axial skeleton. Chordomas commonly recur following surgery and radiotherapy, and there is no effective systemic therapy.
Andrew Bassim Hassan +13 more
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The unresolved case of sacral chordoma: from misdiagnosis to challenging surgery and medical therapy resistance. [PDF]
, 2014 PURPOSE: A sacral chordoma is a rare, slow-growing, primary bone tumor, arising from embryonic notochordal remnants. Radical surgery is the only hope for cure.
Cherix, S. +7 more
core +2 more sources
Expression of
Journal of Experimental & Clinical Cancer Research, 2010 Background Chordoma was a typically slow-growing tumor. The therapeutic approach to chordoma had traditionally relied mainly on surgical therapy. And the main reason for therapeutic failure was resistance to chemotherapy and radiotherapy.
Ma Baoan +8 more
doaj +1 more source
Sacral tumours on MRI : a pictorial essay [PDF]
, 2019 Tumours of the sacrum can be primary or secondary. Since the sacrum is rich in haematopoietic bone marrow, bone metastases are the most frequent aetiologies.
Herregods, Nele +4 more
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A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology. [PDF]
PLoS ONE, 2013 Chordoma is a rare primary bone malignancy that arises in the skull base, spine and sacrum and originates from remnants of the notochord. These tumors are typically resistant to conventional chemotherapy, and to date there are no FDA-approved agents to ...
Matteo M Trucco +15 more
doaj +1 more source
Proton beam therapy in the management of skull base chordomas: systematic review of indications, outcomes, and implications for neurosurgeons [PDF]
, 2016 BACKGROUND: Chordomas are rare tumours affecting the skull base. There is currently no clear consensus on the post-surgical radiation treatments that should be used after maximal tumour resection.
Choi, D, Matloob, SA, Nasir, HA
core +1 more source
MicroRNA-608 and microRNA-34a regulate chordoma malignancy by targeting EGFR, Bcl-xL and MET. [PDF]
PLoS ONE, 2014 Chordomas are rare malignant tumors that originate from the notochord remnants and occur in the skull base, spine and sacrum. Due to a very limited understanding of the molecular pathogenesis of chordoma, there are no adjuvant and molecular therapies ...
Ying Zhang +3 more
doaj +1 more source
Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro. [PDF]
, 2016 Synovial sarcoma is an aggressive soft tissue sarcoma genetically defined by the fusion oncogene SS18-SSX. It is hypothesized that either SS18-SSX disrupts SWI/SNF complex inhibition of the polycomb complex 2 (PRC2) methyltransferase Enhancer of Zeste ...
Choy, Edwin +6 more
core +2 more sources
Recurrent Metastatic Chordoma to the Liver: A Case Report and Review of the Literature
Current Oncology, 2022 Chordoma is a rare malignant neoplasm derived from notochordal tissue that primarily affects the axial skeleton. Almost 40% of patients have non-cranial chordoma metastases.
Thomas E. Dickerson +8 more
doaj +1 more source
Orphanet Journal of Rare Diseases, 2015 Paediatric chordomas are rare malignant tumours arising from primitive notochordal remnants with a high rate of recurrence. Only 5 % of them occur in the first two decades such less than 300 paediatric cases have been reported so far in the literature. In children, the average age at diagnosis is 10 years with a male-to-female ratio closed to 1. On the
Beccaria, Kévin +3 more
openaire +2 more sources