Results 31 to 40 of about 7,206 (161)

Altered Nasal Microbiota in Sinonasal Tumors: A Comparative Analysis of Malignant and Benign Sinonasal Tumors

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Although shifts in nasal microbiota have been well‐documented in inflammatory upper airway conditions, microbiota tumor‐associated alterations remain uncharacterized. This study is the first to compare sinonasal microbiota profiles of patients with malignant tumors (MT), benign tumors (BT), and controls, offering insights into tumor‐
Evan A. Patel, Phillip A. Engen, Glen D. Souza, Sarah Khalife, Donyea Moore, Lauren Kret, Pedro Escobedo, Stefan J. Green, Ankur Naqib, Peter Filip, Peter Papagiannopoulos, Bobby A. Tajudeen, Mahboobeh Mahdavinia, Pete S. Batra   +13 more
wiley   +1 more source

Hematoporphyrin derivative-mediated photodynamic techniques for the diagnosis and treatment of chordoma

Photodiagnosis and Photodynamic Therapy
Background: Chordoma is a rare congenital low-grade malignant tumor characterized by infiltrative growth. It often tends to compress important intracranial nerves and blood vessels, making its surgical treatment extremely difficult. Besides, the efficacy
Lei Li, Kai-lun Wei, Ming-song Liu, Qi-lin Wang, Tong-fei Zeng, Rui-zhe Chen, Xue-wei Xia, Hong-tian Zhang   +7 more
doaj   +1 more source

Low expression of H3K27me3 is associated with poor prognosis in conventional chordoma

Frontiers in Oncology, 2022
PurposeChordoma is a rare and locally invasive neoplasm, and the prognostic factors are limited. Deregulation of Histone 3 lysine 27 (H3K27) trimethylation (H3K27me3) is considered to be related with poor prognosis in some tumors.
Jie Wei, Jianfeng Wu, Zhiyong Yin, Xia Li, Yixiong Liu, Yingmei Wang, Zhe Wang, Chao Xu, Chao Xu, Linni Fan   +9 more
doaj   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Potential molecular mechanism in self-renewal is associated with miRNA dysregulation in sacral chordoma – A next-generation RNA sequencing study

Heliyon, 2022
Background: Chordoma, the most frequent malignant primary spinal neoplasm, characterized by a high rate of recurrence, is an orphan disease where the clarification of the molecular oncogenesis would be crucial to developing new, effective therapies ...
Arpad Bozsodi, Beata Scholtz, Gergo Papp, Zoltan Sapi, Adam Biczo, Peter Pal Varga, Aron Lazary   +6 more
doaj   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Long Non-Coding RNA KCNQ1OT1 Promotes Multidrug Resistance in Chordoma by Functioning as a Molecular Sponge of miR-27b-3p and Subsequently Increasing ATF2 Expression

Cancer Management and Research, 2020
Lei Li, Guohua Lv, Bing Wang, Hong Ma Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of ChinaCorrespondence: Hong Ma Tel +86 731-85295124Email spinema@csu.edu ...
Li L, Lv G, Wang B, Ma H
doaj  

Early Initiation of Adjuvant Therapy Following Pediatric Endoscopic Endonasal Surgery for Tumors

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To evaluate complication rates of early adjuvant therapy initiation in pediatric patients with endoscopic endonasal resection for skull base tumors. Design Retrospective case series of pediatric patients (0–18 years old) with skull base tumors who underwent endoscopic endonasal resection between 2013 and 2023.
Heta Patel, Alan D. Workman, David K. Lerner, Phillip J. Storm, Jennifer E. Douglas, Nithin D. Adappa, James N. Palmer, Michael A. Kohanski   +7 more
wiley   +1 more source

Perineal chordoma cutis, a rare localization for a rare pathology: a case report and consideration of the literature

PAMJ Clinical Medicine, 2020
The chordoma is a very rare notochordal tumor, the cutaneous localization (chordoma cutis) is even rarer and generally follows a local invasion of the integument even a metastasis. The clinical presentation is non-specific and the diagnosis is often late.
Chennoufi Mehdi, Mhanna Tarik, Irzi Mohamed, Jdaini Ahmed, Boukhannous Ibrahim, Barki Ali   +5 more
doaj   +1 more source

Bibliometric Insights in Advances of Chordoma: Global Trends and Research Development in the Last Decade

Orthopaedic Surgery, 2023
Chordoma is a rare tumor, but has a serious effect on the quality of life of patients. This study aims to assess the overall knowledge structure and trends in the development of chordoma research using a bibliometric analysis and visualization tool ...
Yu Xiao, Wenlong Yu, Jianhu Zheng, Lin Cheng, Xing Ding, Liang Qiao, Xuequn Wu, Junming Ma   +7 more
doaj   +1 more source