The unresolved case of sacral chordoma: from misdiagnosis to challenging surgery and medical therapy resistance. [PDF]
, 2014 PURPOSE: A sacral chordoma is a rare, slow-growing, primary bone tumor, arising from embryonic notochordal remnants. Radical surgery is the only hope for cure.
Cherix, S. +7 more
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Spotlight on zebrafish:translational impact [PDF]
, 2014 In recent years, the zebrafish has emerged as an increasingly prominent model in biomedical research. To showcase the translational impact of the model across multiple disease areas, Disease Models & Mechanisms has compiled a Special Issue that includes ...
Amatruda, James F +3 more
core +2 more sources
Sacral tumours on MRI : a pictorial essay [PDF]
, 2019 Tumours of the sacrum can be primary or secondary. Since the sacrum is rich in haematopoietic bone marrow, bone metastases are the most frequent aetiologies.
Herregods, Nele +4 more
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Frontiers in Oncology, 2021 BackgroundChordoma, an extremely rare malignant tumor, remains difficult to be cured because of its strong local invasiveness and high recurrence rate. Long non-coding RNAs (lncRNAs) have been demonstrated to play multiple roles in various cancers.
Kai Zhang +10 more
doaj +1 more source
Unexpected Long-Term Disease Control in Lung Cancer With Sacral Metastases After Conventional Radiotherapy and Chemotherapy Despite Discontinuation of Maintenance Therapy: A Case Report. [PDF]
Clin Case RepABSTRACT Novel treatments, including stereotactic body radiotherapy (SBRT), targeted therapies, and immune checkpoint inhibitors (ICIs), have improved the prognosis and outcomes of patients with metastatic lung cancer. However, not all patients are eligible for these treatments; furthermore, these novel therapies are not readily available in developing
Bayani R +3 more
europepmc +2 more sources
Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell lines. [PDF]
, 2014 OBJECT: Chordoma cells can generate solid-like tumors in xenograft models that express some molecular characteristics of the parent tumor, including positivity for brachyury and cytokeratins. However, there is a dearth of molecular markers that relate to
Alcorta, David A +10 more
core +1 more source
Expression of
Journal of Experimental & Clinical Cancer Research, 2010 Background Chordoma was a typically slow-growing tumor. The therapeutic approach to chordoma had traditionally relied mainly on surgical therapy. And the main reason for therapeutic failure was resistance to chemotherapy and radiotherapy.
Ma Baoan +8 more
doaj +1 more source
A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology. [PDF]
PLoS ONE, 2013 Chordoma is a rare primary bone malignancy that arises in the skull base, spine and sacrum and originates from remnants of the notochord. These tumors are typically resistant to conventional chemotherapy, and to date there are no FDA-approved agents to ...
Matteo M Trucco +15 more
doaj +1 more source
Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR [PDF]
, 2016 Chordomas are rare primary malignant bone tumors arising from embryonal notochord remnants of the axial skeleton. Chordomas commonly recur following surgery and radiotherapy, and there is no effective systemic therapy.
Andrew Bassim Hassan +13 more
core +3 more sources
Proton beam therapy in the management of skull base chordomas: systematic review of indications, outcomes, and implications for neurosurgeons [PDF]
, 2016 BACKGROUND: Chordomas are rare tumours affecting the skull base. There is currently no clear consensus on the post-surgical radiation treatments that should be used after maximal tumour resection.
Choi, D, Matloob, SA, Nasir, HA
core +1 more source