Results 41 to 50 of about 19,276 (249)

Establishment and genomic characterization of the new chordoma cell line Chor-IN-1

Scientific Reports, 2017
Chordomas are rare, slowly growing tumors with high medical need, arising in the axial skeleton from notochord remnants. The transcription factor “brachyury” represents a distinctive molecular marker and a key oncogenic driver of chordomas.
Roberta Bosotti, Paola Magnaghi, Sebastiano Di Bella, Liviana Cozzi, Carlo Cusi, Fabio Bozzi, Nicola Beltrami, Giovanni Carapezza, Dario Ballinari, Nadia Amboldi, Rosita Lupi, Alessio Somaschini, Laura Raddrizzani, Barbara Salom, Arturo Galvani, Silvia Stacchiotti, Elena Tamborini, Antonella Isacchi   +17 more
doaj   +1 more source

XIST sponges miR-320d to promote chordoma progression by regulating ARF6

Journal of Bone Oncology, 2022
Background: Long non-coding RNAs (lncRNAs) have been demonstrated to play important roles in various tumors, including chordoma. The purpose of this study was to investigate the role and mechanism of lncRNA X-inactive specific transcript (XIST) in ...
Yonggang Wang, Zhouzhou Tang, Weichun Guo   +2 more
doaj   +1 more source

In-room test results at CNAO of an innovative PT treatments online monitor (Dose Profiler) [PDF]

, 2018
The use of C, He and O ions as projectiles in Particle Therapy (PT) treatments is getting more and more widespread as a consequence of their enhanced relative biological effectiveness and oxygen enhancement ratio, when compared to the protons one.
Battistoni G., De Simoni M., Dong Y., Embriaco A., Fischetti M., Mancini Terracciano C., Marafini M., Mattei I., Mirabelli R., Muraro S., Patera V., Sarti A., Schiavi A., Sciubba A., Solfaroli Camillocci E., Traini G., Valle S. M.   +16 more
core   +1 more source

Oronasopharyngeal chordomas [PDF]

Acta Neurochirurgica, 2009
Chordomas are rare tumors derived from notochordal remnants. The authors report on a series of three cases of primary familial oronasopharyngeal chordomas treated at our institution.A retrospective chart review was completed of the three cases of primary familial oronasopharyngeal chordoma treated at the University of Utah.All three patients (100 ...
Jeroen R, Coppens, H, Ric Harnsberger, Michael A, Finn, Pramod, Sharma, William T, Couldwell   +4 more
openaire   +2 more sources

Low expression of H3K27me3 is associated with poor prognosis in conventional chordoma

Frontiers in Oncology, 2022
PurposeChordoma is a rare and locally invasive neoplasm, and the prognostic factors are limited. Deregulation of Histone 3 lysine 27 (H3K27) trimethylation (H3K27me3) is considered to be related with poor prognosis in some tumors.
Jie Wei, Jianfeng Wu, Zhiyong Yin, Xia Li, Yixiong Liu, Yingmei Wang, Zhe Wang, Chao Xu, Chao Xu, Linni Fan   +9 more
doaj   +1 more source

Meningioma cordóideo: relato de dois casos [PDF]

, 2003
We present CT scan, MRI and histopathologic findings of two patients harboring a rare type of meningioma. In the first case, a 52 year-old male patient, a large parasellar mass invading the cavernous sinus, infiltrating the infratemporal fossa and ...
Bonatelli, Antonio de Pádua Furquim, Herculano, Marco Antonio, Prandini, Mirto Nelso, Stávale, João Norberto, Tella Junior, Oswaldo Ignácio de   +4 more
core   +4 more sources

Early Initiation of Adjuvant Therapy Following Pediatric Endoscopic Endonasal Surgery for Tumors

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To evaluate complication rates of early adjuvant therapy initiation in pediatric patients with endoscopic endonasal resection for skull base tumors. Design Retrospective case series of pediatric patients (0–18 years old) with skull base tumors who underwent endoscopic endonasal resection between 2013 and 2023.
Heta Patel, Alan D. Workman, David K. Lerner, Phillip J. Storm, Jennifer E. Douglas, Nithin D. Adappa, James N. Palmer, Michael A. Kohanski   +7 more
wiley   +1 more source

Hematoporphyrin derivative-mediated photodynamic techniques for the diagnosis and treatment of chordoma

Photodiagnosis and Photodynamic Therapy
Background: Chordoma is a rare congenital low-grade malignant tumor characterized by infiltrative growth. It often tends to compress important intracranial nerves and blood vessels, making its surgical treatment extremely difficult. Besides, the efficacy
Lei Li, Kai-lun Wei, Ming-song Liu, Qi-lin Wang, Tong-fei Zeng, Rui-zhe Chen, Xue-wei Xia, Hong-tian Zhang   +7 more
doaj   +1 more source

Potential molecular mechanism in self-renewal is associated with miRNA dysregulation in sacral chordoma – A next-generation RNA sequencing study

Heliyon, 2022
Background: Chordoma, the most frequent malignant primary spinal neoplasm, characterized by a high rate of recurrence, is an orphan disease where the clarification of the molecular oncogenesis would be crucial to developing new, effective therapies ...
Arpad Bozsodi, Beata Scholtz, Gergo Papp, Zoltan Sapi, Adam Biczo, Peter Pal Varga, Aron Lazary   +6 more
doaj   +1 more source

Intracranial chordoma presenting as acute hemorrhage in a child: Case report and literature review [PDF]

, 2015
BACKGROUND: Chordomas are rare, slow-growing malignant neoplasms derived from remnants of the embryological notochord. Pediatric cases comprise only 5% of all chordomas, but more than half of the reported pediatric chordomas are intracranial.
Abdulkader, Marwah M., Ackerman, Laurie L., Bohnstedt, Bradley N., Bonnin, Jose M., Kralik, Stephen F., Moore, Kenneth A., Shah, Mitesh V., Shah, Sanket U., Shaikh, Kashif   +8 more
core   +2 more sources