Results 41 to 50 of about 7,206 (161)

Quantitative Susceptibility Mapping in Skull Base Chordoma: In Silico Analysis and In Vivo Application Towards Indirect Hypoxia Assessment

open access: yesMagnetic Resonance in Medicine, Volume 95, Issue 4, Page 2092-2105, April 2026.
ABSTRACT Purpose To evaluate quantitative susceptibility mapping (QSM) beyond the brain through realistic simulations and to explore preliminary evidence that may be indicative of hypoxia in skull base chordomas (SBC). Methods Each step of the QSM pipeline was optimized within an in silico framework consisting of (i) phase unwrapping, (ii) background ...
P. Fenech   +8 more
wiley   +1 more source

Fluid-fluid level as an atypical radiological sign of clival chordoma

open access: yesRadiology Case Reports, 2021
Chordoma is a rare and aggressive intracranial bone tumor that is difficult to diagnose and resect with a peak incident between the ages of 20–40 years old and high recurrence rate when not completely resected.
Fahad B. Albadr   +2 more
doaj   +1 more source

Immunoreactivity for CD34, Desmin, Keratins, KIT, Alpha‐Smooth Muscle Actin, S100, and Vimentin in Malignant Mesenchymal Neoplasms in Guinea Pigs: A Series of 62 Cases From a Single Institution

open access: yesVeterinary Medicine and Science, Volume 12, Issue 2, March 2026.
Immunohistochemical expression of CD34, desmin, keratin AE1/AE3, keratin 8/18, KIT, SMA, S100, and vimentin in normal guinea pig skin serving as both positive and negative external tissue control. All images immunohistochemical staining, 200× magnification, scale bar 100 µm. (A) CD34 stained only vascular endothelium (arrow).
Jiří Lenz   +3 more
wiley   +1 more source

Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish

open access: yesDisease Models & Mechanisms, 2019
The aberrant activation of developmental processes triggers diverse cancer types. Chordoma is a rare, aggressive tumor arising from transformed notochord remnants.
Gianluca D'Agati   +8 more
doaj   +1 more source

Identification of a distinct epigenetic subgroup with inferior PFS in intracranial mesenchymal tumors with FET::CREB fusion

open access: yesBrain Pathology, Volume 36, Issue 2, March 2026.
Six new cases of intracranial mesenchymal tumors with FET::CREB fusion, alongside 20 previously reported cases underwent DNA methylation profiling uncovered a novel epigenetic subgroup distinguished by inferior PFS and unique clinicopathological, molecular, and epigenetic hallmarks.
Yong Lin   +12 more
wiley   +1 more source

Multi‐omics predicts radiotherapy response in small cell lung cancer patients receiving whole brain irradiation

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 2, February 2026.
Abstract Objective Dosiomics and radiomics elaborate the low‐and high‐order features extracted from images to predict clinical outcomes. Whole‐brain radiotherapy (WBRT) has been widely used in patients with diffuse brain metastases of small cell lung cancer (SCLC).
Yifan Lei   +11 more
wiley   +1 more source

Function and regulation of miR-186-5p, miR-125b-5p and miR-1260a in chordoma

open access: yesBMC Cancer, 2023
Background The function and regulation of miRNAs in progression of chordoma were unclear. Methods Five miRNAs were identified by the machine learning method from the miRNA expression array. CCk-8 assay, EDU assay, wound healing migration assay, and trans-
Xulei Huo   +9 more
doaj   +1 more source

Radiogenomics: Current Understandings and Future Perspectives

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Radiogenomics links imaging phenotypes with genetic variations, offering potential for comprehensive understanding, cost‐effective diagnosis, and prognosis prediction to advance personalized medicine. However, its clinical application remains limited by several challenges.
Xinyu Zhang   +8 more
wiley   +1 more source

Children and Adolescents With Localised Non‐Rhabdomyosarcoma Soft Tissue Sarcoma: Results of the CWS‐96 and CWS‐2002P Prospective Trials With Reclassification of the Trial Data Incorporating the Recent Soft Tissue Sarcoma Registry

open access: yesPediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Background Here we report the results of the first comprehensive European trials for all soft tissue sarcoma entities, which aimed to develop a new risk stratification system, limit radiotherapy and chemotherapy for low‐/standard‐risk patients, and evaluate different chemotherapy regimens for high‐risk patients.
Amadeus T. Heinz   +16 more
wiley   +1 more source

Global Prevalence of Chronic Pain Among Cancer Survivors: A Systematic Review and Proportional Meta‐Analysis of Observational Studies

open access: yesWorldviews on Evidence-Based Nursing, Volume 23, Issue 1, February 2026.
ABSTRACT Background Cancer survivors often receive inadequate pain management, leading to impaired quality of life. Despite their importance, evidence on the global prevalence of chronic pain in cancer survivors remains insufficiently clear. Aims The systematic review and proportional meta‐analysis aimed to estimate the pooled global prevalence of ...
Pak Kit Wong   +3 more
wiley   +1 more source

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