Results 41 to 50 of about 19,107 (247)
MicroRNA-608 and microRNA-34a regulate chordoma malignancy by targeting EGFR, Bcl-xL and MET. [PDF]
PLoS ONE, 2014 Chordomas are rare malignant tumors that originate from the notochord remnants and occur in the skull base, spine and sacrum. Due to a very limited understanding of the molecular pathogenesis of chordoma, there are no adjuvant and molecular therapies ...
Ying Zhang +3 more
doaj +1 more source
Recurrent Metastatic Chordoma to the Liver: A Case Report and Review of the Literature
Current Oncology, 2022 Chordoma is a rare malignant neoplasm derived from notochordal tissue that primarily affects the axial skeleton. Almost 40% of patients have non-cranial chordoma metastases.
Thomas E. Dickerson +8 more
doaj +1 more source
Orphanet Journal of Rare Diseases, 2015 Paediatric chordomas are rare malignant tumours arising from primitive notochordal remnants with a high rate of recurrence. Only 5 % of them occur in the first two decades such less than 300 paediatric cases have been reported so far in the literature. In children, the average age at diagnosis is 10 years with a male-to-female ratio closed to 1. On the
Beccaria, Kévin +3 more
openaire +2 more sources
XIST sponges miR-320d to promote chordoma progression by regulating ARF6
Journal of Bone Oncology, 2022 Background: Long non-coding RNAs (lncRNAs) have been demonstrated to play important roles in various tumors, including chordoma. The purpose of this study was to investigate the role and mechanism of lncRNA X-inactive specific transcript (XIST) in ...
Yonggang Wang +2 more
doaj +1 more source
Oronasopharyngeal chordomas [PDF]
Acta Neurochirurgica, 2009 Chordomas are rare tumors derived from notochordal remnants. The authors report on a series of three cases of primary familial oronasopharyngeal chordomas treated at our institution.A retrospective chart review was completed of the three cases of primary familial oronasopharyngeal chordoma treated at the University of Utah.All three patients (100 ...
Jeroen R, Coppens +4 more
openaire +2 more sources
Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro. [PDF]
, 2016 Synovial sarcoma is an aggressive soft tissue sarcoma genetically defined by the fusion oncogene SS18-SSX. It is hypothesized that either SS18-SSX disrupts SWI/SNF complex inhibition of the polycomb complex 2 (PRC2) methyltransferase Enhancer of Zeste ...
Choy, Edwin +6 more
core +2 more sources
Establishment and genomic characterization of the new chordoma cell line Chor-IN-1
Scientific Reports, 2017 Chordomas are rare, slowly growing tumors with high medical need, arising in the axial skeleton from notochord remnants. The transcription factor “brachyury” represents a distinctive molecular marker and a key oncogenic driver of chordomas.
Roberta Bosotti +17 more
doaj +1 more source
Meningioma cordóideo: relato de dois casos [PDF]
, 2003 We present CT scan, MRI and histopathologic findings of two patients harboring a rare type of meningioma. In the first case, a 52 year-old male patient, a large parasellar mass invading the cavernous sinus, infiltrating the infratemporal fossa and ...
Bonatelli, Antonio de Pádua Furquim +4 more
core +4 more sources
Biobanking from the patient perspective [PDF]
, 2015 Biobanks and biobanking research plays an increasingly important role in healthcare research and delivery as health systems become more patient-centred and medicine becomes more personalised. There is also growing acceptance and appreciation of the value
Geissler, Jan +6 more
core +1 more source
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose To evaluate quantitative susceptibility mapping (QSM) beyond the brain through realistic simulations and to explore preliminary evidence that may be indicative of hypoxia in skull base chordomas (SBC). Methods Each step of the QSM pipeline was optimized within an in silico framework consisting of (i) phase unwrapping, (ii) background ...
P. Fenech +8 more
wiley +1 more source