Results 61 to 70 of about 7,206 (161)
World Journal of Otorhinolaryngology-Head and Neck Surgery, 2015 Objective: To investigate the expression of p16, cyclin D1, retinoblastoma tumor suppressor protein (Rb) and MIB-1 in skull base chordoma and chondrosarcoma tissues, and to determine the clinicopathological significance of the above indexes in these ...
Jun-qi Liu +2 more
doaj +1 more source
Medical Physics, Volume 53, Issue 1, January 2026.Abstract Background To ensure accurate, safe, and reproducible patient treatments, it is essential to have precise knowledge and a solid understanding of patient‐specific quality assurance (PSQA). For many years, the delivery of doses to all patients has been verified using dosimetric measurements.
Abdallah Qubala +6 more
wiley +1 more source
Challenging the giant: A case report on a huge sacrococcygeal chordoma and its radiological insights
Radiology Case ReportsSacral chordoma is a rare osseous tumor of malignant origin. Remnants of the notochord in the region of sacrum and coccyx is said to be the origin of these tumors.
Sakshi Dudhe, MBBS +6 more
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APMIS, Volume 134, Issue 1, January 2026.ABSTRACT Hemangioblastoma (HB) is a benign central nervous system (CNS) tumor associated with mutations in the von Hippel–Lindau (VHL) gene. Although rare outside the CNS, the pathological and genetic features remain poorly understood. We analyzed four renal hemangioblastomas (RHB). Demographics, clinical presentation, and follow‐up data were collected.
Boglárka Pósfai +17 more
wiley +1 more source
The driver landscape of sporadic chordoma
Nature Communications, 2017 Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations
Patrick S. Tarpey +31 more
doaj +1 more source
Imaging Findings of a Nonenhancing Intradural Paramedian Chordoma Mimicking an Epidermoid Cyst
대한영상의학회지, 2018 Intracranial chordoma is a rare tumor, originating from embryonic remnants of the primitive notochord. It typically appears as an enhancing extradural midline tumor with bone involvement.
Min Jeong Kim, Yae Won Park, Soo Mee Lim
doaj +1 more source
Spinal Cord, 1987 Intraspinal chordomas are rare tumors, comprising about 1% of central nervous system tumors. They are derived from notochordal elements which have failed to degenerate and are mainly found in the sphenooccipital and sacrococcygeal regions. These tumors are very slowly growing, are virtually impossible to excise completely and only metastasise in about ...
openaire +2 more sources
RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy
Advanced ScienceChordoma, a rare mesenchymal malignancy, exhibits a high tendency to postoperative recurrence and poor prognosis. To date, its tumorigenic regulatory mechanisms remain elusive, leading to a lack of effective therapeutic targets and drug sensitivity ...
Jianxuan Gao +15 more
doaj +1 more source
Journal of the Belgian Society of Radiology, 2013 A 38-year-old man was admitted to our hospital for deep sacral pain. There was no significant medical history. Physical examination revealed pressure pain of the right sacroiliac joint. MRI showed a midline mass in the sacrum (arrows), isointense on T1- weighted MR images and hyperintense on T2-weighted MR images (Fig.
Behaeghe, M +3 more
openaire +5 more sources
A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12
Disease Models & Mechanisms, 2014 Chordoma is a malignant tumor thought to arise from remnants of the embryonic notochord, with its origin in the bones of the axial skeleton. Surgical resection is the standard treatment, usually in combination with radiation therapy, but neither ...
Alexa Burger +7 more
doaj +1 more source