Results 81 to 90 of about 19,107 (247)

EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen. [PDF]

, 2016
Chordoma is a rare malignant bone tumour with a poor prognosis and limited therapeutic options. We undertook a focused compound screen (FCS) against 1097 compounds on three well-characterized chordoma cell lines; 154 compounds were selected from the ...
Amary, F, Barnard, M, Brüderlein, S, Cottone, L, Drewry, DH, Flanagan, AM, Guppy, N, Jorgensen, M, Leite, AP, Leithner, A, Möller, P, Pillay, N, Scheipl, S, Smith, JA, Strauss, SJ, Tirabosco, R, Turlais, F, Ye, H, Zuercher, WJ   +18 more
core   +1 more source

A Case Report of HIV‐Associated Pituitary Lymphoma and Review of the Literature

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Primary saddle region tumors are the most commonly pituitary adenomas: They account for more than 90% of all saddle region tumors. Primary central nervous system lymphoma (PCNSL) lesions are relatively rare and are usually found around the ventricles. Reports of PCNSL lesions located in the saddle region are even rarer.
Yahui Cui, Yuxiao Yuan, Liangyan Jin, Xiantu Zhang, Hui Hou   +4 more
wiley   +1 more source

Radiation‐Induced Biological Effects: Molecular and Cellular Mechanism, and Applications to Radiation/Nuclear Emergency and Cancer Therapy

MedComm, Volume 6, Issue 12, December 2025.
Radiation‐induced biological effects are an extremely complex and extensive mechanism that involves multiple aspects of physiological activities in organisms. In the medical field, utilizing the damaging effects of radiation to treat tumors is a commonly employed therapeutic approach.
Zhihe Hu, Yan Chen, Shengyi Yang, Shihai Diao, Le Ma, Chunmeng Shi   +5 more
wiley   +1 more source

A Comparative Ultrastructural Study of Chondrosarcoma, Chordoid Sarcoma, and Chordoma [PDF]

, 1981
A morphologic and electron microscopic study was made of two chordoid sarcomas. These lesions were compared with two classical chondrosarcomas and two chordomas.
Guillen, F.J. (F. J.), Pardo-Mindan, F.J. (Francisco Javier), Vazquez, J.J. (Jesús Jaime), Villas-Tome, C. (Carlos)   +3 more
core   +1 more source

The diagnostic landscape of bone and soft tissue sarcoma: the pan‐sarcoma era and AI‐driven classification

The Journal of Pathology: Clinical Research, Volume 11, Issue 6, November 2025.
Abstract Bone and soft tissue sarcomas are a diagnostic challenge due to their histological complexity, variety, and mutational heterogeneity. This has led to continued refinements in classification and diagnostic criteria, presented and soon to be updated by the WHO.
William CH Cross
wiley   +1 more source

Coupling of small leucine-rich proteoglycans to hypoxic survival of a progenitor cell-like subpopulation in Rhesus Macaque intervertebral disc [PDF]

, 2013
Degeneration of the intervertebral disc (IVD) is a major spinal disorder that associates with neck and back pain. Recent studies of clinical samples and animal models for IVD degeneration have identified cells with multi-potency in the IVD.
Chan, D, Cheung, KMC, Huang, S, Leung, VYL, Long, D, Lu, WW, Zhou, G   +6 more
core   +1 more source

A Ten‐Step Surgical Approach to Radical Excision of a Primary Ischiorectal Fossa Tumor With IGAP V‐Y Flap Reconstruction—A Case Report of a Rare Myxofibrosarcoma

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT This case report presents a rare case of ischiorectal fossa myxofibrosarcoma, which was successfully excised with a clear margin and full preservation of the patient's pudendal nerve function. We present our surgical technique in 10 steps, describing the surgical excision and reconstructive surgery with the inferior gluteal artery perforator V‐
Amy Whitmore, Sabina Ioana Nistor, Muhammad Ather Siddiqi, Roman Mykula, Hooman Soleymani majd   +4 more
wiley   +1 more source

N6‐methyladenosine‐modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis

Clinical and Translational Medicine
Background Chordoma, a rare bone tumour with aggressive local invasion and high recurrence rate with limited understanding of its molecular mechanisms. Circular RNAs (circRNAs) have been extensively implicated in tumorigenesis, yet their involvement in ...
Hanwen Li, Yingchuang Tang, Xingbang Ruan, Junxin Zhang, Hao Liu, Shiyu Yu, Hao Chen, Huilin Yang, Kai Zhang, Kangwu Chen   +9 more
doaj   +1 more source

Immune microenvironment and immunotherapy for chordoma

Frontiers in Oncology
Chordoma, as a rare, low-grade malignant tumor that tends to occur in the midline of the body, grows slowly but often severely invades surrounding tissues and bones.
Yujia Chen, Hongwei Zhang
doaj   +1 more source

Clinicopathological significance of p16, cyclin D1, Rb and MIB-1 levels in skull base chordoma and chondrosarcoma

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2015
Objective: To investigate the expression of p16, cyclin D1, retinoblastoma tumor suppressor protein (Rb) and MIB-1 in skull base chordoma and chondrosarcoma tissues, and to determine the clinicopathological significance of the above indexes in these ...
Jun-qi Liu, Qiu-hang Zhang, Zhen-lin Wang   +2 more
doaj   +1 more source