Results 21 to 30 of about 10,464 (192)

The effects of mifepristone on the structure of human decidua and chorion and Bax and Bcl-2 expression at early stage of pregnancy

BMC Pharmacology and Toxicology, 2022
Background As a progesterone receptor antagonist, mifepristone combined with misoprostol is widely used to terminate early pregnancy in clinical practice.
Fei Tian, Hua Han, Ligang Jia, Junqin Zhang, Zhaoping Chu, Jie Li, Yuan Zhang, Ping Yan   +7 more
doaj   +1 more source

Molecular and morphological peculiarities of chronic placental insufficiency formation caused by different types of diabetes mellitus

Сахарный диабет, 2020
Рathogenesis of the chronic placental insufficiency is largely determined by the type of diabetes mellitus and the degree of its compensation. Trophic function failure of placenta changes its hormonal activity, formation of respiratory disorders and ...
Tatyana G. Tral, Gulrukhsor Kh. Tolibova, Ekaterina V. Musina, Maria I. Yarmolinskaya   +3 more
doaj   +1 more source

Histological characteristics of the uterine cavity scraping in women with hyperprolactinemia of various origins, complicated by terminating pregnancy

Patologìâ, 2013
The main morphological feature in spontaneous abortions in hyperprolactinemia of various origin is reduced activity of invasive cytotrophoblast. At the same time a decrease in utero-placental barrier and increased hypoxia, resulting in dystrophic and ...
A.A. Trushkevich, T.G. Filonenko, E.P. Golubinskaya, I.N. Platonova, A.A. Dovgan, A.A. Shirokova   +5 more
doaj   +1 more source

Ingrown chorionic villi of the first trimester as a result of a non-developing pregnancy in the post-cesarean scar, associated with the development of arteriovenous malformation: а clinical case

Alʹmanah Kliničeskoj Mediciny, 2023
Background: Identification of residual chorionic tissue and ingrowing chorionic villi after uterine cavity curettage due to non-developing pregnancy, spontaneous abortions, and medical abortions has been a poorly studied problem.
Polina V. Kulabukhova, Olga S. Kondrashina, Dmitry M. Akinfiev, Vladimir G. Bychenko   +3 more
doaj   +1 more source

Evidence for contamination as the origin for bacteria found in human placenta rather than a microbiota.

PLoS ONE, 2020
Until recently the in utero environment of pregnant women was considered sterile. Recent high-sensitivity molecular techniques and high-throughput sequencing lead to some evidence for a low-biomass microbiome associated with the healthy placenta.
Rémi Gschwind, Thierry Fournier, Sean Kennedy, Vassilis Tsatsaris, Anne-Gaël Cordier, Frédéric Barbut, Marie-José Butel, Sandra Wydau-Dematteis   +7 more
doaj   +1 more source

Evidence for HPV DNA in the placenta of women who resorted to elective abortion

BMC Pregnancy and Childbirth, 2021
Background It is believed that HPV infection can result in the death of placental trophoblasts and cause miscarriages or preterm birth. In clinical cases of placental villi positive for HPV DNA reported by other authors, contamination is suspected in the
Maria Teresa Bruno, Salvatore Caruso, Francesca Bica, Giulia Arcidiacono, Sara Boemi   +4 more
doaj   +1 more source

Human Placental NADPH Oxidase Mediates sFlt-1 and PlGF Secretion in Early Pregnancy: Exploration of the TGF-β1/p38 MAPK Pathways

Antioxidants, 2021
Preeclampsia, a hypertensive disorder occurring during pregnancy, is characterized by excessive oxidative stress and trophoblast dysfunction with dysregulation of soluble Fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) production ...
Isabelle Hernandez, Audrey Chissey, Jean Guibourdenche, Roger Atasoy, Xavier Coumoul, Thierry Fournier, Jean-Louis Beaudeux, Amal Zerrad-Saadi   +7 more
doaj   +1 more source

Triploidy--Observations in 154 Diandric Cases. [PDF]

PLoS ONE, 2015
Hydatidiform moles (HMs) are abnormal human pregnancies with vesicular chorionic villi, imposing two clinical challenges; miscarriage and a risk of gestational trophoblastic neoplasia (GTN).
Nanna Brink Scholz, Lars Bolund, Mette Nyegaard, Louise Faaborg, Mette Warming Jørgensen, Helle Lund, Isa Niemann, Lone Sunde   +7 more
doaj   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source