Results 141 to 150 of about 10,527 (218)

New Inhibitors of Chorismate Synthase Present Antifungal Activity Against Paracoccidioides Brasiliensis

Future Microbiology, 2019
Aim: A structural model of chorismate synthase (CS) from the pathogenic fungus Candida albicans was used for virtual screening simulations. Methods: Docking, molecular dynamics, cell growth inhibition and protein binding assays were used for search and ...
Seixas Fa, Peter Macheroux, Marina Toplak   +2 more
exaly   +2 more sources

Partial inactivation of chorismate mutase-prephenate dehydrogenase from Escherichia coli in the presence of analogues of chorismate

International Journal of Biochemistry and Cell Biology, 1997
Chorismate-5,6-epoxide, chorismate-5,6-diol, various adamantane derivatives and 2-hydroxy-phenyl acetate are structural analogues of chorismate that act as competitive inhibitors of both the chorismate mutase and prephenate dehydrogenase activities of the bifunctional enzyme, hydroxyphenylpyruvate synthase.
Richard I Christopherson, R I Christopherson   +1 more
exaly   +3 more sources

Chorismate mutase in microorganisms and plants

Phytochemistry, 1995
The enzymology of chorismate mutase in plants and microorganisms is reviewed to include occurrence, gene-enzyme relationships, reaction mechanisms and details of active site studies.
J D Phillipson
exaly   +2 more sources

Mycobacterium tuberculosis chorismate mutase: A potential target for TB

Bioorganic and Medicinal Chemistry, 2017
Manojit Pal, K Shiva Kumar, Gopalakrishnan Bulusu   +2 more
exaly   +2 more sources

Identification of potent inhibitors against chorismate synthase of Toxoplasma gondii using molecular dynamics simulations.

Journal of Molecular Graphics and Modelling, 2022
Toxoplasmosis, caused by Toxoplasma gondii, affects about 20-30% of the human population every year globally. The emergence of severe side effects of current chemotherapeutics and drug-resistant strains emphasize upon finding new therapeutics to treat ...
Samayaditya Singh, I. Qureshi
semanticscholar   +1 more source

An evolution-based model for designing chorismate mutase enzymes

Science, 2020
Learning from evolution Protein sequences contain information specifying their three-dimensional structure and function, and statistical analysis of families of sequences has been used to predict these properties. Building from sequence data, Russ et al.
W. P. Russ, M. Figliuzzi, Christian Stocker, Pierre Barrat-Charlaix, M. Socolich, P. Kast, D. Hilvert, R. Monasson, S. Cocco, M. Weigt, R. Ranganathan   +10 more
semanticscholar   +1 more source

Chorismate mutase-catalyzed reaction of (±)-chorismic acid

Biochemical and Biophysical Research Communications, 1982
Abstract Chorismate mutase-prephenate dehydrogenase from E. coli and chorismate mutase from S. aureofaciens do not catalyze the conversion of (+)-chorismate (unnatural enantiomer) to prephenate. (+)-Chorismate does not inhibit the isomerization of (−)-chorismate to prephenate with chorismate mutaseprephenate dehydrogenase from E ...
J H, Hoare, G A, Berchtold
openaire   +2 more sources

The shikimate pathway. Part V. Chorismic acid and chorismate mutase

Journal of the Chemical Society, Perkin Transactions 1, 1976
The chemistry of the biochemical intermediate chorismic acid {trans-3-[(1-carboxyvinyl)oxy]-4-hydroxycyclohexa-1,5-diene-1-carboxylic acid}(1) is discussed, including the formation of the fused pyrazoline (6) with diazomethane, the dihydro-derivatives (8) and (9) with di-imide, and the epoxide (10).
R J, Ife, L F, Ball, P, Lowe, E, Haslam
openaire   +2 more sources

Validated MAGIC and GWAS populations mapping reveal the link between vitamin E contents and natural variation in chorismate metabolism in tomato.

The Plant Journal, 2020
Tocochromanols constitute the different forms of vitamin E (VTE), essential for the human diet and display a high membrane protectant activity. By combining interval mapping and genome-wide association studies (GWAS) we unveiled the genetic determinants ...
Estanislao Burgos, Maria De Luca, Isidore Diouf, L. A. de Haro, Elise Albert, Christopher Sauvage, Zhao Jian Tao, L. Bermudez, R. Asis, Adriano Nunes Nesi, M. Matringe, Claire Bréhélin, Thomas Guiraud, C. Ferrand, Isabelle Atienza, Joana Jorly, J. Mauxion, P. Baldet, A. Fernie, L. Quadrana, C. Rothan, M. Causse, F. Carrari   +22 more
semanticscholar   +1 more source

A Definitive Mechanism for Chorismate Mutase

Biochemistry, 2005
In previous research presentations, we have described the important features of the chorismate --> prephenate reaction using molecular dynamics (MD) and thermodynamic integration studies. This investigation of the reaction in Escherichia coli and water involves QM/MM procedures (SCCDFTB/MM two-dimensional reaction coordinates to identify transition ...
Xiaodong, Zhang, Xiaohua, Zhang, Thomas C, Bruice   +2 more
openaire   +2 more sources