Results 151 to 160 of about 10,527 (218)
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Biotechnology Advances
Chorismate serves not only as a critical branch point for aromatic amino acids biosynthesis, but also as an essential precursor for various high-value aromatic compounds.
Xuewei Pan +6 more
semanticscholar +1 more source
Chorismate serves not only as a critical branch point for aromatic amino acids biosynthesis, but also as an essential precursor for various high-value aromatic compounds.
Xuewei Pan +6 more
semanticscholar +1 more source
Journal of the American Chemical Society, 1983
Synthese totale de l'acide chorismique (±) en 11 etapes a partir du cyclohexene-3 carboxylate de methyle.
John H. Hoare +2 more
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Synthese totale de l'acide chorismique (±) en 11 etapes a partir du cyclohexene-3 carboxylate de methyle.
John H. Hoare +2 more
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Structural basis of chorismate isomerization by Arabidopsis ISOCHORISMATE SYNTHASE1.
Plant PhysiologySalicylic acid (SA) plays a crucial role in plant defense against biotrophic and semi-biotrophic pathogens. In Arabidopsis (Arabidopsis thaliana), isochorismate synthase 1 (AtICS1) is a key enzyme for the pathogen-induced biosynthesis of SA via catalytic
Zihui Su +7 more
semanticscholar +1 more source
Bioorganic chemistry (Print), 2019
The chorismate mutase (CM) is considered as an attractive target for the identification of potential antitubercular agents due to its absence in animals but not in bacteria.
Gangireddy Sujeevan Reddy +9 more
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The chorismate mutase (CM) is considered as an attractive target for the identification of potential antitubercular agents due to its absence in animals but not in bacteria.
Gangireddy Sujeevan Reddy +9 more
semanticscholar +1 more source
Biochemistry, 1982
Inhibition data (I50 values) have been obtained for inhibitors of the chorismate mutase activity of chorismate mutase-prephenate dehydrogenase from Aerobacter aerogenes. Several 1-substituted adamantane derivatives were investigated; the order of decreasing inhibitory activity with the various substituents was -PO32- much greater than -P(OCH3)O2 ...
H S, Chao, G A, Berchtold
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Inhibition data (I50 values) have been obtained for inhibitors of the chorismate mutase activity of chorismate mutase-prephenate dehydrogenase from Aerobacter aerogenes. Several 1-substituted adamantane derivatives were investigated; the order of decreasing inhibitory activity with the various substituents was -PO32- much greater than -P(OCH3)O2 ...
H S, Chao, G A, Berchtold
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Biochemistry, 1977
The enzymically catalyzed conversion of chorismate to prephenate may proceed through either a chair-like or a boat-like transition state. To distinguish between these alternatives, we have prepared a series of structural analogues of the two possible transition state structures and tested them as inhibitors of chorismate mutase-prephenate dehydrogenase
P R, Andrews +3 more
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The enzymically catalyzed conversion of chorismate to prephenate may proceed through either a chair-like or a boat-like transition state. To distinguish between these alternatives, we have prepared a series of structural analogues of the two possible transition state structures and tested them as inhibitors of chorismate mutase-prephenate dehydrogenase
P R, Andrews +3 more
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Chorismate lyase: kinetics and engineering for stability
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 2002By removing the enolpyruvyl group from chorismate, chorismate lyase (CL) produces p-hydroxybenzoate (p-HB) for the ubiquinone biosynthetic pathway. We have analyzed CL by several spectroscopic and chemical techniques and measured its kinetic (kcat=1.7 s(-1), K(m)=29 microM) and product inhibition parameters (K(p)=2.1 microM for p-HB).
M J, Holden +3 more
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Microbial production and NMR characterization of [2,6,9-13C]chorismate and [1,3,5,8-13C]chorismate
Bioorganic & Medicinal Chemistry Letters, 1993Abstract Chorismate is a biosynthetic precursor of the aromatic amino acids and many natural products. [2,6,9- 13 C]Chorismate and [1,3,5,8- 13 C]chorismate have been prepared microbially from [1- 13 C]glucose and [2- 13 C]glucose, respectively, using the culture filtrates of Klebsiella pneumonia strain 62-1. This is an inexpensive, time saving and
Jayanthi S. Rajagopalan, Eileen K. Jaffe
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Molecular Physics, 2018
The Bacillus subtilis chorismate mutase catalysed Claisen rearrangement of chorismate to prephenate is one of the few pericyclic processes in biology, and as such provides a rare opportunity for understanding how Nature promotes such rearrangements so ...
M. Freindorf +4 more
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The Bacillus subtilis chorismate mutase catalysed Claisen rearrangement of chorismate to prephenate is one of the few pericyclic processes in biology, and as such provides a rare opportunity for understanding how Nature promotes such rearrangements so ...
M. Freindorf +4 more
semanticscholar +1 more source
An engineered chorismate mutase with allosteric regulation
Bioorganic & Medicinal Chemistry, 2003Besides playing a central role in phenylalanine biosynthesis, the bifunctional P-protein in Eschericia coli provides a unique model system for investigating whether allosteric effects can be engineered into protein catalysts using modular regulatory elements.
Sheng, Zhang +2 more
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