Results 51 to 60 of about 4,684 (170)
Global Challenges, Volume 9, Issue 12, December 2025.This study integrates computational and experimental approaches to explore how short dipeptides modulate the activity of chorismate synthase. Unexpectedly, the GluAsp dipeptide enhanced enzyme activity by promoting a transient surface channel near the active site, possibly revealing a new structural feature relevant for microbial metabolism and ...
Lorenzo Pedroni +4 more
wiley +1 more source
MicrobiologyOpen, Volume 14, Issue 6, December 2025.The novel Paenibacillus sp. strain 210, isolated from Brazilian crude oil, its genome encoding 259 carbohydrate‐active enzymes for degrading cellulose, xylan, and pectin, positioning it as a candidate for biofuel production. The strain harbors complete pathways for B‐vitamin biosynthesis and antimicrobial biosynthetic clusters (e.g., fusaricidin and ...
João Victor dos Anjos Almeida +5 more
wiley +1 more source
Microbial Biotechnology, Volume 18, Issue 12, December 2025.This study explores the metabolic potential of Lentilactobacillus hilgardii for malolactic fermentation in winemaking. Genomic and in silico analyses, combined with experimental validation, reveal its resilience at low temperatures and unique enzymatic traits. Comparative insights with Oenococcus oeni highlight L.
Giacomo Mantegazza +5 more
wiley +1 more source
Modular optimization of heterologous pathways for de novo synthesis of (2S)-naringenin in Escherichia coli. [PDF]
PLoS ONE, 2014 Due to increasing concerns about food safety and environmental issues, bio-based production of flavonoids from safe, inexpensive, and renewable substrates is increasingly attracting attention.
Junjun Wu +4 more
doaj +1 more source
Yeast expression of a catalytic antibody with chorismate mutase activity
Journal of Biological Chemistry, 1991 The catalytic antibody 1F7 promotes the rearrangement of chorismate into prephenate. We cloned and sequenced the genes encoding this catalyst to determine the origin of the observed rates and specificity. The antibody cDNAs were modified and inserted into inducible expression vectors.
K, Bowdish +3 more
openaire +2 more sources
Molecular Plant Pathology, Volume 26, Issue 12, December 2025.This pathogen profile explores sugarcane (Saccharum spp.) smut caused by Sporisorium scitamineum, highlighting advances in pathogen biology, molecular pathogenesis, host resistance and management ABSTRACT Sugarcane smut, caused by the fungus Sporisorium scitamineum, is a devastating disease that threatens sugar production, leading to significant yield ...
Zhen Zeng +7 more
wiley +1 more source
In Vivo Biosynthesis and Direct Incorporation of Noncanonical Amino Acids into Proteins
ChemBioChem, Volume 26, Issue 22, November 17, 2025.This review evaluates engineered (semi)autonomous cell systems for the biosynthesis and incorporation of noncanonical amino acids (ncAAs) into proteins. While semi‐autonomous cells convert supplied precursors into ncAAs autonomous cells integrate biosynthetic pathways that produce these building blocks intracellularly.
Jan Hendrik Illies +2 more
wiley +1 more source
Food Frontiers, Volume 6, Issue 6, Page 2575-2590, November 2025.Metabolic syndrome is characterized by abdominal obesity, hyperglycemia, dyslipidemia, and hypertension. Bioactive compounds extracted from herbs, tea, and coffee using microbial cell factories, particularly resveratrol and caffeic acid, have demonstrated remarkable potential in the management of metabolic syndrome, offering innovative solutions for ...
Tao Li +7 more
wiley +1 more source
A flexible, allosteric loop regulates protein activity and rewires electrostatics
Protein Science, Volume 34, Issue 10, October 2025.Abstract Allostery is a key driver of protein function and behavior in biological systems. Historically, allosteric regulation has been attributed to conformational and dynamic changes, mostly derived from well‐structured regions of proteins. While the regulatory contributions of specific unstructured elements, such as catalytic loops near the active ...
Darex J. Vera‐Rodríguez +3 more
wiley +1 more source
Plants strike back: Kiwellin proteins as a modular toolbox for plant defense mechanisms
Communicative & Integrative Biology, 2019 Plants have to cope with numerous stresses in nature to avoid damage or cell death. We recently reported a class of plant defense proteins termed kiwellins that were initially found in kiwifruit and shown to be causative to human food allergies.
Gert Bange, Florian Altegoer
doaj +1 more source