Results 151 to 160 of about 78,813 (321)

Differential Organ Ageing Is Associated With Age‐Related Macular Degeneration

open access: yesAging Cell, EarlyView.
Using the UK Biobank, this study trained neural networks to estimate the biological age of individuals according to markers of organ function. Computing the difference between the estimated organ age and chronological age yielded an estimate for accelerated or slowed ageing.
Anastasios Papadam   +2 more
wiley   +1 more source

A Concept-based Interpretable Model for the Diagnosis of Choroid Neoplasias using Multimodal Data [PDF]

open access: yesarXiv
Diagnosing rare diseases presents a common challenge in clinical practice, necessitating the expertise of specialists for accurate identification. The advent of machine learning offers a promising solution, while the development of such technologies is hindered by the scarcity of data on rare conditions and the demand for models that are both ...
arxiv  

Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD‐Like Pathology in Mice

open access: yesAging Cell, EarlyView.
Our study reveals that overactivation of both mTOR complexes through mLST8 in RPE cells triggers AMD‐like pathology and cellular dysfunction. This finding highlights the critical role of balanced mTOR signaling in retinal health and suggests that targeting both complexes could be therapeutic for AMD treatment.
Olivia Chowdhury   +27 more
wiley   +1 more source

Uncertainty Quantification in Detecting Choroidal Metastases on MRI via Evolutionary Strategies [PDF]

open access: yesarXiv
Uncertainty quantification plays a vital role in facilitating the practical implementation of AI in radiology by addressing growing concerns around trustworthiness. Given the challenges associated with acquiring large, annotated datasets in this field, there is a need for methods that enable uncertainty quantification in small data AI approaches ...
arxiv  

Partial agenesis of the corpus callosum: Prenatal ultrasound characteristics, associations, and outcome

open access: yesActa Obstetricia et Gynecologica Scandinavica, EarlyView.
Abnormal cavum septi pellucidi is the most common indirect sign of partial agenesis of corpus callosum (pACC). A cystic mass in the midline that communicates with the third ventricle may be an indirect sign of pACC. PACC is highly associated with intra‐ and extracranial malformations.
Changrong Zhou   +8 more
wiley   +1 more source

Two‐year changes of macular choroidal thickness in response to 0.01% atropine eye drops: Results from the myopia outcome study of atropine in children (MOSAIC) clinical trial

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To investigate 2‐year changes in macular choroidal thickness (ChT) in children receiving 0.01% atropine eyedrops and its relationship with spherical equivalent refraction (SER) progression and axial length (AL) elongation. Methods A total of 250 myopic children aged 6–16 years (167%–0.01% atropine, 83‐placebo) were enrolled in the ...
Emmanuel Kobia‐Acquah   +3 more
wiley   +1 more source

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