Results 181 to 190 of about 128,759 (361)

Senescence Alters Antimicrobial Peptide Expression and Induces Amyloid‐β Production in Retinal Pigment Epithelial Cells

open access: yesAging Cell, EarlyView.
Healthy RPE cells produce AMPs and AMP precursors, including amyloid precursor protein (APP) and chemerin, and protect the neuroretina from blood‐borne pathogens and maintain homeostasis. When RPE cells undergo senescence, the antibacterial activity declines, and APP undergoes amylogenesis, leading to Aβ deposition.
Jian Liu   +7 more
wiley   +1 more source

Contribution to the theory of photopic vision: Retinal phenomena [PDF]

open access: yes
Principles of thermodynamics are applied to the study of the ultramicroscopic anatomy of the inner eye. Concepts introduced and discussed include: the retina as a three-dimensional sensor, light signals as coherent beams in relation to the dimensions of ...
Calvet, H.
core   +1 more source

Age‐Dependent Histone Deacetylase 3 Regulation by βA3/A1‐Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age‐Related Macular Degeneration

open access: yesAging Cell, EarlyView.
βA3/A1‐crystallin regulates HDAC3 activity and epigenetic processes in the RPE. (A) The illustration demonstrates that βA3/A1‐crystallin plays a crucial role in maintaining IPMK protein expression, which in turn activates HDAC3. (B) When βA3/A1‐crystallin is absent (Cryba1 KO ), IPMK protein expression decreases, resulting in the deactivation of HDAC3.
Sujan Chatterjee   +16 more
wiley   +1 more source

A Prenatal Case of Focal Dermal Hypoplasia With Split Hand/Foot Malformation, Lack of Characteristic Skin Findings, Renal Agenesis, and Coloboma Due To a Novel PORCN Variant

open access: yes
Prenatal Diagnosis, EarlyView.
Molly Jackson   +6 more
wiley   +1 more source

Proteomic Signatures of Epigenetic Age in African Green Monkey Cerebrospinal Fluid and Plasma

open access: yesAging Cell, EarlyView.
Epigenetic age together with plasma and CSF proteomes were quantified in a large number of African green monkeys. This study identified new accessible protein biomarkers (“clocks”) for understanding aging biology and to track changes in the rate of biological aging in a translationally relevant nonhuman primate model.
John D. Elsworth   +9 more
wiley   +1 more source

Two‐year changes of macular choroidal thickness in response to 0.01% atropine eye drops: Results from the myopia outcome study of atropine in children (MOSAIC) clinical trial

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To investigate 2‐year changes in macular choroidal thickness (ChT) in children receiving 0.01% atropine eyedrops and its relationship with spherical equivalent refraction (SER) progression and axial length (AL) elongation. Methods A total of 250 myopic children aged 6–16 years (167%–0.01% atropine, 83‐placebo) were enrolled in the ...
Emmanuel Kobia‐Acquah   +3 more
wiley   +1 more source

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