Results 231 to 240 of about 995,221 (398)

GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets

Advanced Science, EarlyView.
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu, Haowen Jiang, Yichang Liu, Chang Peng, Hanlin Wang, Wenhua Yang, Zan Lyu, Yan Sun, Huan Ma, Hongyu Gu, Weijuan Kan, Liya Jing, Tiancheng Dong, Chunmei Xia, Saifei Lei, Rui Wu, Jinlong Li, Jia Li   +17 more
wiley   +1 more source

The role of lysine-rich histone in the maintenance of chromatin structure in metaphase chromosomes.

, 1968
A. E. Mirsky, Carolyn J. Burdick, Eric H. Davidson, Virginia C. Littau   +3 more
openalex   +1 more source

Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency. [PDF]

Epigenetics Chromatin
Venu V, Small EM, Roth C, Adikari SH, Vlot AHC, Sullivan KA, Abeyratne CR, Jacobson D, Starkenburg SR, Sanbonmatsu KY, Steadman CR.   +10 more
europepmc   +1 more source

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

Modification of tadpole liver chromatin by thyroxine treatment.

, 1966
K H Kim, P P Cohen
openalex   +1 more source

THE ABILITY OF DNA AND CHROMATIN OF DEVELOPING FROG EMBRYOS TO PRIME FOR RNA POLYMERASE-DEPENDENT RNA SYNTHESIS [PDF]

, 1965
R.A. Flickinger, S. J. Coward, M. Miyagi, Christina Möser, E. Rollins   +4 more
openalex   +1 more source

Deficiency of SCAMP5 Triggers Pancreatic β‐Cell Secretory Dysfunction and Apoptosis

Advanced Science, EarlyView.
This study demonstrates that hyperglycemia in diabetes activates ChREBP, which epigenetically represses SCAMP5 expression in pancreatic β‐cells. This SCAMP5 deficiency impairs insulin secretion by downregulating the calcium channel CaV1.2. Furthermore, reduced SCAMP5 triggers β‐cell apoptosis by stabilizing VDAC1 and enhancing its interaction with Bax,
Yingqi Zhang, Donglan Tang, Chenxi Yang, Chao Lin, Yingyue Yuan, Meiying He, Yiying Chen, Zhuo Mao, Ying Ying, Xiaosong Ma, Xiangchen Kong   +10 more
wiley   +1 more source

HETEROCHROMATIN AND GENETIC ACTIVITY IN MEALY BUGS I. COMPENSATION FOR INACTIVE CHROMATIN BY INCREASE IN CELL NUMBER [PDF]

, 1968
Laurence Berlowitz, Mary W. Loewus, Dominick Pallotta   +2 more
openalex   +1 more source

WUSCHEL-dependent chromatin regulation in maize inflorescence development at single-cell resolution. [PDF]

Genome Biol
Bang S, Zhang X, Gregory J, Luo Z, Chen Z, Minow MAA, Galli M, Gallavotti A, Schmitz RJ.   +8 more
europepmc   +1 more source

FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology

Advanced Science, EarlyView.
FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This study reveals that brain endothelial cells rely on oxidative phosphorylation rather than glycolysis alone, challenging the current metabolic paradigm and ...
Wenzheng Zou, Yuqing Lv, Lin Li, Shukui Zhang, Jiaqi Liang, Chengchao Wu, Enyu Huang, Jianwei Jiao, Jingjing Zhang   +8 more
wiley   +1 more source