Results 231 to 240 of about 971,786 (390)

Static three-dimensional structures determine fast dynamics between distal loci pairs in interphase chromosomes. [PDF]

Sci Adv
Shi G, Shin S, Thirumalai D.
europepmc   +1 more source

LincNEAT1 Encoded‐NEAT1‐31 Promotes Phagocytosis by Directly Activating the Aurora‐A–PI3K–AKT Pathway

Advanced Science, EarlyView.
LincNEAT1 Encoded‐NEAT1‐31 micropeptide directly binds with Aurora‐A and enhanced AKT pathways to pormotes phagocytosis against multi cancer cells. Abstract Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation.
Jie Li, Jing Zhang, Xixi Li, Xin Liu, Bo Zeng, Jiayue Luo, Huijin Wang, Hanbing Zhang, Xinya Gao   +8 more
wiley   +1 more source

STEMIN transcription factor drives selective chromatin remodeling for gene activation within a relaxed chromatin during reprogramming in the moss Physcomitrium patens. [PDF]

Plant J
de Villiers RM, Palfalvi G, Kanai A, Suzuki Y, Hasebe M, Ishikawa M.   +5 more
europepmc   +1 more source

Stimulation of hen erythrocyte chromatin by extracts of rat liver or uterus [PDF]

, 1969
R E Leake, J. M. Barry
openalex   +1 more source

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source

Single nucleosome imaging reveals principles of transient multiscale chromatin reorganization triggered by histone ADP-ribosylation at DNA lesions. [PDF]

Nat Commun
García Fernández F, Park J, Chapuis C, Pinto Jurado E, Imburchia V, Smith R, José Longarini E, Taddei A, Hubert C, Sokolovska N, Matić I, Huet S, Miné-Hattab J.   +12 more
europepmc   +1 more source

The role of lysine-rich histone in the maintenance of chromatin structure in metaphase chromosomes.

, 1968
A. E. Mirsky, Carolyn J. Burdick, Eric H. Davidson, Virginia C. Littau   +3 more
openalex   +1 more source

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

Proceedings of the National Academy of Sciences of the United States of America, 2009
A. Khalil, M. Guttman, Maite Huarte, Manuel Garber, A. Raj, Dianali Rivea Morales, Kelly Thomas, Aviva Presser, B. Bernstein, A. van Oudenaarden, A. Regev, E. Lander, J. Rinn   +12 more
semanticscholar   +1 more source

PTPN2 Inhibition Disrupts Mitochondrial Renewal and Blocks TFRC‐Mediated Mitophagy to Exert Anti‐Tumor Activities in ALK‐Positive Anaplastic Large Cell Lymphoma

Advanced Science, EarlyView.
CRISPR/Cas9 screening reveals PTPN2 as essential for ALK+ ALCL survival. PTPN2 regulates TFRC to promote PINK1‐PRKN mitophagy. Oral PTPN2 inhibitor ABBV‐CLS‐484 disrupts mitochondrial renewal and blocks TFRC‐mediated mitophagy to exert anti‐tumor activities, supporting clinical development for ALK+ ALCL.
Wei‐Ting Wang, Zi‐Wen Duan, Tong‐Yao Xing, Wei Hua, Kai‐Xing Du, Chun‐Yu Shang, Yi‐Fan Wu, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu   +11 more
wiley   +1 more source

Histone acetylation readers Bdf1 and Yaf9 direct SWR1 remodeler to +1 nucleosome. [PDF]

Sci Adv
Ranjan A, Elalaoui E, Tang X, Cha J, Louder RK, Nguyen K, Ye J, Bennani M, Gardner AM, Liu D, Pugh BF, Wu C.   +11 more
europepmc   +1 more source