Results 231 to 240 of about 834,176 (358)

Microscale Thermophoresis Analysis of Chromatin Interactions

, 2018
Ivan Corbeski, Velten Horn, Ramon A. van der Valk, Ulric B. le Paige, Remus T. Dame, Hugo van Ingen   +5 more
openalex   +2 more sources

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

Advanced Science, EarlyView.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan, Senlin Li, Shuai Liu, Hong Zhou, Yue Xu, Wenhui Li, Mengxuan Wang, Mengheng Wang, Mengzhu Zheng, Wenxi Shi, Xin Li, Yiting Feng, Ming Xiang   +12 more
wiley   +1 more source

Srcap Chromatin Remodeler Is Required for Efficient Replication Dynamics in Mammalian Cells. [PDF]

Int J Mol Sci
Dzhokova SK, Hristova RH, Botev PS, Guecheva TN, Gospodinov AG.   +4 more
europepmc   +1 more source

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, EarlyView.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source

Cohesin drives chromatin scanning during the RAD51-mediated homology search. [PDF]

Science
Marin-Gonzalez A, Rybczynski AT, Nilavar NM, Nguyen D, Li AG, Karwacki-Neisius V, Zou RS, Avilés-Vázquez FJ, Kanemaki MT, Scully R, Ha T.   +10 more
europepmc   +1 more source

U‐Shaped Response of Flowering Time to Low and High Nitrogen via a Transcription Feedback Loop in Rice

Advanced Science, EarlyView.
The “seesaw effect” of Nhd1‐Ghd7 module in regulating flowering time (days to heading in rice) responses to nitrogen (N) via Hd3a/RFT1: deficient‐N (DN) delays flowering via Ghd7‐mediated suppression of Nhd1; moderate‐N (MN) impairs this suppression, enhancing Nhd1 to promote flowering; whereas superior‐N (SN) delays flowering by Nhd1‐activated ...
Shunan Zhang, Guanzhong Shou, Xianping Li, Xuemin Song, Xuesong Li, Junjie Guo, Jiaqiang Lu, Yi Jin, Hongye Qu, Ming Yan, Wona Ding, Ying Liu, Guohua Xu   +12 more
wiley   +1 more source

Resolving interface structure and local internal mechanics of mitotic chromosomes. [PDF]

Nat Commun
Ridolfi A, Witt H, Harju J, Clement TVM, Peterman EEJG, Broedersz CP, Wuite GJL.   +6 more
europepmc   +1 more source

H2A.Z-Mediated Genome-Wide Chromatin Specialization

, 2007
José M. Eirín‐López, Juan Ausió
openalex   +2 more sources

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Site-specific phosphorylation of LRP regulates <i>FLC</i> chromatin looping and flowering. [PDF]

Sci Adv
Fan S, Zhang Y, Zhu S, Teng Z, Zhang Q, Yan Y, Shen L.   +6 more
europepmc   +1 more source