Results 281 to 290 of about 995,221 (398)

SIRT6 Lysine‐Demyristoylates ATF2 to Ameliorate Vascular Injury via PRKCD/VE‐Cadherin Pathway Regulating Vascular Endothelial Barrier

Advanced Science, EarlyView.
A novel modified SIRT6 variant (dSIRT6) H133Y‐mediated enrichment technique unmasks 15 new human lysine‐myristoylated proteins. Notably, Sirtuin 6 (SIRT6) demyristoylation of activating transcription factor 2 (ATF2) at K296 orchestrates its nucleoplasmic translocation.
Runyang Feng, Zheyan Fang, Shuang Zhao, You‐en Zhang, Na Wu, Zhenyang Guo, Xin Zhong, Bixuan Jiang, Hongfei Xu, Hangnan Hong, Zhentao Zhang, Mukaddas Abdurahman, Xueting Yu, Jilong Geng, Xiansu Nie, Supuya Abuduwahapi, Dong Huang, Gang Zhao, Wenbin Zhang, Hao Lu, Li Shen, Xin Zhao, Zhaoyang Chen, Junjie Guo, Hongchao Zheng, Yue He, Sanwu Wu, Jiayin Peng, Jiawen Song, Xiao Wang, Haomin Li, Yuli Huang, Shengying Qin, Haojie Lu, Xiangdong Wang, Jianguo Zhao, Lei Huang, Yun Zhao, Peng Li, Junbo Ge, Hua Li   +40 more
wiley   +1 more source

Differential regulation of mesoscale chromosome conformations in osteoblasts and osteosarcoma. [PDF]

Genome Biol
Bisht M, Chung YC, He SL, Willey S, Sunkel BD, Wang M, Stanton BZ, Tu LC.   +7 more
europepmc   +1 more source

SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks

Advanced Science, EarlyView.
SCRIPT is a novel method inferring single‐cell cis‐regulatory relationships (CRRs) from transcriptomic and chromatin accessibility data. SCRIPT incorporates two key innovations: graph causal attention networks supported by empirical CRR evidence, and representation learning enhanced through pretraining on atlas‐scale single‐cell data.
Yu Zhang, Baole Wen, Yifeng Jiao, Yuchen Liu, Xin Guo, Yushuai Wu, Jiyang Li, Limei Han, Yinghui Xu, Xin Gao, Yuan Qi, Yuan Cheng, Ying He, Weidong Tian   +13 more
wiley   +1 more source

Palmitoyltransferase ZDHHC19 regulates histone-to-protamine exchange during spermiogenesis in mice. [PDF]

Sci Adv
Li J, Xia Z, Jiao B, Li Z, Li D, Xu P, Huang Y, Nie J, Dan Y, Huang X, Yan L, Zhang R, Huang W, Wang X, Ji S, Liu M, Liu P, Ren R.   +17 more
europepmc   +1 more source

CircSMEK1 Suppresses HCC via the hnRNPK‐IGF2‐AKT Axis: A Diagnostic Biomarker and Therapeutic Target

Advanced Science, EarlyView.
CircSMEK1 is downregulated in MASH/HCC and predicts poor prognosis. It suppresses tumor progression by promoting hnRNPK ubiquitination and inhibiting the IGF2/PI3K/AKT axis, while its loss activates immunosuppressive cancer‐associated fibroblasts. Serum circSMEK1 serves as a non‐invasive diagnostic biomarker, and its restoration potently inhibits HCC ...
Peilan Guo, Xiaomeng Jia, Shenghong Wang, Xinyu Li, Yajing Liu, Lisen Lin, Zhengkun Wang, Fujun Liu, Slawomir Wolczynski, Nafis Rahman, Jie Gao, Xuguang Du, Suk‐Ying Tsang, Jiali Liu, Wei Song, Xiangdong Li   +15 more
wiley   +1 more source

Chromatin-state discovery and genome annotation with ChromHMM

Nature Protocols, 2017
J. Ernst, Manolis Kellis
semanticscholar   +1 more source

Quantitative single-cell imaging suggests increased global chromatin accessibility in tumor versus non-tumor cell lines. [PDF]

iScience
Commane M, Jadhav V, Leonova K, Buckley B, Withers H, Gurova K.   +5 more
europepmc   +1 more source

Hypoxia‐Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O‐GlcNAcylation

Advanced Science, EarlyView.
Under hypoxia, HIF1A is directly bound to the PRELID2 promoter to increase PRELID2 pre‐mRNA expression, followed by the DYRK1A–SFPQ–SAM68 complex binding to Alu‐containing introns in PRELID2 pre‐mRNA, leading to circPRELID2 circularization. CircPRELID2 interacts with PCBP1 and promotes its cytoplasmic retention.
Pengshan Zhang, Zai Luo, Yitian Xu, Yuan Zhang, Renchao Zhang, Nadina Paerhati, Shaopeng Zhang, Qianqian Cai, Zhengjun Qiu, Chen Huang   +9 more
wiley   +1 more source

The Association of a Metabolite of Vitamin D3 with Intestinal Mucosa Chromatin in Vivo

, 1968
Mark R. Haussler, James F. Myrtle, Anthony W. Norman   +2 more
openalex   +1 more source

A new link in the leukemia genetic puzzle. [PDF]

Genes Dev
Wu X, Levine RL.
europepmc   +1 more source