Results 51 to 60 of about 971,786 (390)
Modulation of the functional interfaces between retroviral intasomes and the human nucleosome
mBio, 2023 Infection by retroviruses as HIV-1 requires the stable integration of their genome into the host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called intasomes, and their interaction with the target DNA wrapped around ...
E. Mauro +18 more
doaj +1 more source
Cantharidin downregulates PSD1 expression and inhibits autophagic flux in yeast cells
FEBS Open Bio, 2022 Cantharidin is a terpenoid compound of insect origin, naturally produced by male blister beetles as an antipredatory mechanism. Cantharidin has anticancer properties, which are attributed to its ability to induce cell cycle arrest, DNA damage, MAPK ...
Swati Swagatika, Raghuvir Singh Tomar
doaj +1 more source
The accessible chromatin landscape of the human genome
Nature, 2012 DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, insulators, silencers and locus control regions.
R. Thurman +58 more
semanticscholar +1 more source
Science, 2020 A new layer of transcriptional control N6-methyladenosine (m6A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m6A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs ...
Jun Liu +10 more
semanticscholar +1 more source
Molecular Biology of the Cell, 2011 Recent advances in our understanding of chromosome behavior have been made possible by the development of cutting-edge cytological and molecular techniques. Presentations in this Minisymposium applied these techniques to a diverse set of topics. Sarah Elgin (Washington University) described her lab’s studies on the 1360 transposable element in ...
Lori L. Wallrath, David M. Gilbert
openaire +3 more sources
Characterization of chromatin accessibility with a transposome hypersensitive sites sequencing (THS-seq) assay. [PDF]
, 2016 Chromatin accessibility captures in vivo protein-chromosome binding status, and is considered an informative proxy for protein-DNA interactions. DNase I and Tn5 transposase assays require thousands to millions of fresh cells for comprehensive chromatin ...
Fung, Ho-Lim +6 more
core +2 more sources
Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development. [PDF]
, 2018 During the phylotypic period, embryos from different genera show similar gene expression patterns, implying common regulatory mechanisms. Here we set out to identify enhancers involved in the initial events of cardiogenesis, which occurs during the ...
Bruneau, Benoit G +5 more
core +3 more sources
Genome Biology, 2020 Background Chromosomes are subdivided spatially to delimit long-range interactions into topologically associating domains (TADs). TADs are often flanked by chromatin insulators and transcription units that may participate in such demarcation. Remarkably,
Alexandre Heurteau +6 more
doaj +1 more source
Fractionation and characterization of euchromatin isolated from mouse ascites sarcoma cells [PDF]
, 1978 Euchromatin specimen prepared by the usual method formed large clumps and had various shapes under electron microscopy. A method of separation of the euchromatin specimen into chromatin fractions having relatively homogeneous form was examined and ...
Inaba, Kozo +2 more
core +1 more source
Stem Cells International, 2018 Accumulating evidences indicate that many tumors rely on subpopulations of cancer stem cells (CSCs) with the ability to propagate malignant clones indefinitely and to produce an overt cancer.
Vittoria Poli +2 more
doaj +1 more source