Results 121 to 130 of about 28,191 (215)

Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells

Cell Division, 2006
In eukaryotic cells, replication of genomic DNA initiates from multiple replication origins distributed on multiple chromosomes. To ensure that each origin is activated precisely only once during each S phase, a system has evolved which features periodic
Fujita Masatoshi
doaj   +1 more source

The Histone Chaperone Asf1p Mediates Global Chromatin Disassembly in Vivo*

Journal of Biological Chemistry, 2004
The packaging of the eukaryotic genome into chromatin is likely to be mediated by chromatin assembly factors, including histone chaperones. We investigated the function of the histone H3/H4 chaperones anti-silencing function 1 (Asf1p) and chromatin ...
Melissa W. Adkins, J. Tyler
semanticscholar   +1 more source

CDK1 and PLK1 coordinate the disassembly and reassembly of the nuclear envelope in vertebrate mitosis

bioRxiv, 2017
Micronuclei (MN) arise from chromosomes or fragments that fail to be incorporated into the primary nucleus after cell division. These structures are a major source of genetic instability caused by DNA repair and replication defects coupled to aberrant ...
I. J. de Castro, Raquel Sales Gil, Lorena Ligammari, M. L. Di Giacinto, P. Vagnarelli   +4 more
semanticscholar   +1 more source

Histone Chaperone Jun Dimerization Protein 2 (JDP2): Role in Cellular Senescence and Aging

Kaohsiung Journal of Medical Sciences, 2010
Transcription factor Jun dimerization protein 2 (JDP2) binds directly to histones and DNA, and inhibits p300-mediated acetylation of core histones and reconstituted nucleosomes that contain JDP2-recognition DNA sequences.
Yu-Chang Huang, Shigeo Saito, Kazunari Kzaushige Yokoyama   +2 more
doaj   +1 more source

Asf1a resolves bivalent chromatin domains for the induction of lineage-specific genes during mouse embryonic stem cell differentiation

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance ES cells possess the unique capacity to self-renew as well as differentiate into specialized cell types. It is known that transcription factors and chromatin regulators regulate the cell-fate choices during differentiation.
Yuan Gao, Haiyun Gan, Zhenkun Lou, Zhiguo Zhang   +3 more
semanticscholar   +1 more source

A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing

Cell Reports, 2019
Summary: FACT (facilitates chromatin transcription) is an evolutionarily conserved histone chaperone that was initially identified as an activity capable of promoting RNA polymerase II (Pol II) transcription through nucleosomes in vitro.
Theophilus T. Tettey, Xin Gao, Wanqing Shao, Hua Li, Benjamin A. Story, Alex D. Chitsazan, Robert L. Glaser, Zach H. Goode, Christopher W. Seidel, Ronald C. Conaway, Julia Zeitlinger, Marco Blanchette, Joan W. Conaway   +12 more
doaj  

Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells

Oncogenesis
Desmoplastic small round cell tumor (DSRCT) is an aggressive pediatric cancer caused by the EWSR1-WT1 fusion oncoprotein. The tumor is refractory to treatment with a 5-year survival rate of only 15–25%, necessitating the development of novel therapeutics,
Justin W. Magrath, Dane A. Flinchum, Alifiani B. Hartono, Shruthi Sanjitha Sampath, Tina M. O’Grady, Melody Baddoo, Liang Haoyang, Xiaojiang Xu, Erik K. Flemington, Sean B. Lee   +9 more
doaj   +1 more source

Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice

Scientific Reports
Transforming acidic acid coiled-coil protein 3 (TACC3) and cytoskeleton associated protein 5 (cKAP5; or colonic hepatic tumor overexpressed gene, chTOG) are vital for spindle assembly and stabilization initiated through TACC3 Aurora-A kinase interaction.
Calvin Simerly, Emily Robertson, Caleb Harrison, Sydney Ward, Charlize George, Jasmine Deleon, Carrie Hartnett, Gerald Schatten   +7 more
doaj   +1 more source

An Entry/Gateway^® cloning system for general expression of genes with molecular tags in Drosophila melanogaster

BMC Cell Biology, 2009
Background Tagged fusion proteins are priceless tools for monitoring the activities of biomolecules in living cells. However, over-expression of fusion proteins sometimes leads to the unwanted lethality or developmental defects.
Eyer Katie, Oliver Daniel, Akbari Omar S, Pai Chi-Yun   +3 more
doaj   +1 more source

ASF1 Proteins are Involved in UV-induced DNA Damage Repair and are Cell Cycle Regulated by E2F Transcription Factors in Arabidopsis thaliana [PDF]

, 2013
ASF1 is a key histone H3/H4 chaperone that participates in a variety of DNA and chromatin-related processes, including DNA repair, where chromatin assembly and disassembly is of primaryrelevance.
Casati, Paula, Gutierrez, Crisanto, Lario, Luciana Daniela, Ramirez Parra, Elena, Spampinato, Claudia Patricia   +4 more
core   +1 more source