Results 51 to 60 of about 28,191 (215)

Homologous Recombination: To Fork and Beyond [PDF]

, 2018
Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair ...
Prado Velasco, José Félix
core   +1 more source

Dynamic Changes in Occupancy of Histone Variant H2A.Z during Induced Somatic Cell Reprogramming

Stem Cells International, 2016
The development of induced pluripotent stem cells (iPSCs) has enabled study of the mechanisms underlying cellular reprogramming. Here, we have studied the dynamic distribution of H2A.Z during induced reprogramming with chromatin immunoprecipitation deep ...
Fulu Dong, Zhenwei Song, Jiali Yu, Baole Zhang, BaoChun Jiang, Ying Shen, Youde Lu, Chunlei Song, Peiqing Cong, Honglin Liu   +9 more
doaj   +1 more source

Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes

Journal of Experimental Medicine, 2018
&NA; Expression of Rag1 and Rag2 is tightly regulated in developing T cells to mediate TCR gene assembly. Here we have investigated the molecular mechanisms governing the assembly and disassembly of a transcriptionally active RAG locus chromatin hub in ...
A. Naik, A. Byrd, Aaron C K Lucander, M. Krangel   +3 more
semanticscholar   +1 more source

TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response. [PDF]

, 2015
The spindle checkpoint acts during cell division to prevent aneuploidy, a hallmark of cancer. During checkpoint activation, Mad1 recruits Mad2 to kinetochores to generate a signal that delays anaphase onset.
Bhalla, Needhi, Chen, Pin-Hsi, Hwang, Tom, Nelson, Christian R   +3 more
core   +1 more source

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution [PDF]

, 2013
NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a ...
Andrew Bowman, Andrew Stirling, Andrews, Berndsen, Bonangelino, Bowman, Colin M. Hammond, Das, David A. Robinson, David G. Norman, Del Rosario, Dmitri I. Svergun, Driscoll, D’Arcy, D’Arcy, Fillingham, Fleissner, Hagelueken, Hansen, Hassane El-Mkami, Ishimi, Jeschke, Kolonko, Konarev, Krogan, Kuryan, Laskey, McBryant, McBryant, Milov, Newman, Noda, Ohkuni, Park, Park, Petoukhov, Pramila, Ransom, Richard Ward, Roessle, Schwieters, Selth, Selth, Su, Svergun, Svergun, Tang, Tang, Tom Owen-Hughes, Toth, Tsubota, Ward, Weifeng Shang, Xue   +53 more
core   +7 more sources

Mechanism of curaxin-dependent nucleosome unfolding by FACT

Frontiers in Molecular Biosciences, 2022
Human FACT (FACT) is a multifunctional histone chaperone involved in transcription, replication and DNA repair. Curaxins are anticancer compounds that induce FACT-dependent nucleosome unfolding and trapping of FACT in the chromatin of cancer cells (c ...
Olesya I. Volokh, Anastasia L. Sivkina, Andrey V. Moiseenko, Andrey V. Moiseenko, Anna V. Popinako, Maria G. Karlova, Maria E. Valieva, Maria E. Valieva, Maria E. Valieva, Elena Y. Kotova, Mikhail P. Kirpichnikov, Timothy Formosa, Vasily M. Studitsky, Vasily M. Studitsky, Olga S. Sokolova   +14 more
doaj   +1 more source

Epigenetic regulation of centromeric chromatin: old dogs, new tricks? [PDF]

, 2008
The assembly of just a single kinetochore at the centromere of each sister chromatid is essential for accurate chromosome segregation during cell division.
A Aguilera, A Alonso, AG Castillo, AL Lam, AR Mitchell, AW Lo, B Li, B Sullivan, BA Sullivan, BA Sullivan, BA Sullivan, BA Sullivan, BA Weaver, BC Williams, BE Black, BE Black, BE Black, BG Mellone, BJ Buchwitz, BP May, C Polizzi, CG Pearson, CL Rieder, CN Topp, CW Carroll, D Reinberg, D Vermaak, DK Palmer, DR Foltz, E Yeh, EM Dunleavy, ES Chen, ES Chen, G Mizuguchi, G Mizuguchi, Gary H. Karpen, GH Karpen, H Bouzinba-Segard, H Izuta, H Tagami, H Yan, H Yan, HD Folco, HP Cam, HS Malik, I Grummt, IK Greaves, J Gregan, J Walfridsson, JA Mello, JJ Harrington, JM Sogo, JM Spence, K Ahmad, K Ahmad, K Ishii, K Sugasawa, K Takahashi, K Takahashi, K Yoda, KA Maggert, KC Keith, KF Sullivan, KH Choo, KM Hahnenberger, KV Bulazel, L Clarke, LE Jansen, LH Wong, M Agudo, M Baum, M Buhler, M Ikeno, M Nakano, M Okada, M Schuh, MD Blower, MD Blower, MD Meneghini, N Conde e Silva, NC Steiner, P Heun, P Neumann, PB Meluh, PE Warburton, PE Warburton, PS Maddox, R Camahort, R Saffery, R Saffery, RD Shelby, RD Shelby, RK Dawe, RM Raisner, Robin C. Allshire, S Furuyama, S Henikoff, S Henikoff, S Henikoff, S Rea, S Saitoh, S Stoler, S Stoler, S Westermann, SG Zeitlin, SI Grewal, SK Williams, SM Kim, SR Carlson, T Furuyama, T Hassold, T Hayashi, T Jenuwein, T Kouzarides, T Maruyama, T Okada, TD Murphy, W Rocha, WC Earnshaw, Y Dalal, Y Fujita, Y Mito, Y Takayama, Y Takayama, ZL Monaco   +124 more
core   +1 more source

RRM3 regulates epigenetic conversions in Saccharomyces cerevisiae in conjunction with Chromatin Assembly Factor I

The Nucleus, 2016
Chromatin structures are transmitted to daughter cells through a complex system of nucleosome disassembly and re-assembly at the advancing replication forks.
Brandon A. Wyse, Roxanne Oshidari, Hollie Rowlands, Sanna Abbasi, K. Yankulov   +4 more
semanticscholar   +1 more source

Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling [PDF]

, 2012
Sperm chromatin remodeling after oocyte entry is the essential step that initiates embryogenesis. This reaction involves the removal of sperm-specific basic proteins and chromatin assembly with histones. In mammals, three nucleoplasmin/nucleophosmin (NPM)
Akashi, Satoko, Hisaoka, Miharu, Nagata, Kyosuke, Nishimura, Yoshifumi, Okuwaki, Mitsuru, Saotome-Nakamura, Ai, Sumi, Ayako   +6 more
core   +2 more sources

Histone chaperone Asf1 plays an essential role in maintaining genomic stability in fission yeast. [PDF]

PLoS ONE, 2012
The histone H3-H4 chaperone Asf1 is involved in chromatin assembly (or disassembly), histone exchange, regulation of transcription, and chromatin silencing in several organisms. To investigate the essential functions of Asf1 in Schizosaccharomyces pombe,
Katsuhiro Tanae, Tomitaka Horiuchi, Yuzy Matsuo, Satoshi Katayama, Makoto Kawamukai   +4 more
doaj   +1 more source