Results 81 to 90 of about 28,191 (215)

Phenotypic and molecular spectra of patients with switch/sucrose nonfermenting complex-related intellectual disability disorders in Korea

BMC Medical Genomics, 2021
Background The switch/sucrose nonfermenting (SWI/SNF) complex is an adenosine triphosphate-dependent chromatin-remodeling complex associated with the regulation of DNA accessibility. Germline mutations in the components of the SWI/SNF complex are related
Yena Lee, Yunha Choi, Go Hun Seo, Gu-Hwan Kim, Changwon Keum, Yoo-Mi Kim, Hyo-Sang Do, Jeongmin Choi, In Hee Choi, Han-Wook Yoo, Beom Hee Lee   +10 more
doaj   +1 more source

Spatio-Temporal Coordination of Transcription Preinitiation Complex Assembly in Live Cells

bioRxiv, 2020
Transcription initiation by RNA polymerase II (Pol II) requires preinitiation complex (PIC) assembly at gene promoters. In the dynamic nucleus where thousands of promoters are broadly distributed in chromatin, it is unclear how ten individual components ...
V. Q. Nguyen, A. Ranjan, Sheng Liu, Xiaona Tang, Y. Ling, J. Wisniewski, G. Mizuguchi, K. Li, Vivian Jou, Qinsi Zheng, L. Lavis, T. Lionnet, Carl Wu   +12 more
semanticscholar   +1 more source

A Chemogenetic Toolkit for Inducible, Cell Type‐Specific Actin Disassembly

Small Methods, EarlyView.
ChiActs are novel actin‐perturbing genetic tools that can be rapidly activated by chemical actuators and optogenetically targeted to distinct subcellular locations using light. ChiActs rapidly induce actin disassembly in several model cell types and are able to perturb actin‐dependent nano‐assembly and cellular functions, including inhibition of ...
Tien‐Hung Lan, Nicholas Ambiel, Yi‐Tsang Lee, Tatsuki Nonomura, Yubin Zhou, J. Bradley Zuchero   +5 more
wiley   +1 more source

Temporal differences in the appearance of NEP-B78 and an LBR-like protein during Xenopus nuclear envelope reassembly reflect the ordered recruitment of functionally discrete vesicle types [PDF]

, 1999
In this work, we have used novel mAbs against two proteins of the endoplasmic reticulum and outer nuclear membrane, termed NEP-B78 and p65, in addition to a polyclonal antibody against the inner nuclear membrane protein LBR (lamin B receptor), to study ...
Acharya, Ashery, Ashery, Benavente, Buendia, Burke, Chaudhary, Collas, Dabauvalle, Ellenberg, FirmbachKraft, Foisner, Franke, Gerace, Gerace, Glass, Hepler, Hutchison, Jenkins, Latterich, Lourim, Lourim, Marshall, Newport, Newport, Ottaviano, Pfaller, Pyrpasopoulou, Rabouille, Roos, Rothman, Smythe, Stick, Ulitzur, Vigers, Vigers, Wiese, Wilson, Worman, Yang, Ye, Zeligs   +41 more
core   +3 more sources

Site-specific interaction of the murine pre-replicative complex with origin DNA: assembly and disassembly during cell cycle transit and differentiation

Nucleic Acids Research, 2007
Eukaryotic DNA replication initiates at origins of replication by the assembly of the highly conserved pre-replicative complex (pre-RC). However, exact sequences for pre-RC binding still remain unknown.
E. Zellner, T. Herrmann, Carsten Schulz, F. Grummt   +3 more
semanticscholar   +1 more source

Upregulation of ST3GAL5 predicts suppression of malignant biological behavior in bladder cancer

UroPrecision, EarlyView.
Abstract Background Bladder cancer (BLCA) is the most prevalent malignancy in the urinary tract system, while ST3GAL5 is a protein‐coding gene that catalyzes the formation of ganglioside monosialodihexosylganglioside 3 (GM3) synthase. GM3 synthase has been reported to significantly influence the malignant process of various cancers.
Song Ou‐Yang, Lei Tang, Lin Li, Yawei Zhao   +3 more
wiley   +1 more source

The Dynamics of Lamin a During the Cell Cycle

Frontiers in Molecular Biosciences, 2021
Lamin proteins play an essential role in maintaining the nuclear organization and integrity; and lamin A, in particular, plays a major role in the whole volume of the nuclear interior.
Anat Vivante, Irit Shoval, Yuval Garini, Yuval Garini   +3 more
doaj   +1 more source

Applications of spatial transcriptomics in studying spermatogenesis

Andrology, EarlyView.
Abstract Spermatogenesis is a complex differentiation process that is facilitated by a series of cellular and molecular events. High‐throughput genomics approaches, such as single‐cell RNA sequencing, have begun to enable the systematic characterization of these events. However, the loss of tissue context because of tissue disassociations in the single‐
Qianlan Xu, Haiqi Chen
wiley   +1 more source

Pharmacological levels of withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells [PDF]

, 2014
Withaferin A (WA) isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-based
A Albini, A Cock-Rada, A Grigoriadis, An Wouters, AP Mazar, B Castellana, B Grin, B Jayaprakasam, D Hanahan, D Sarrio, Dariusz Ratman, DG Johnson, DR Hurst, ER Hahm, Erik Fransen, F Pereira, F Zambelli, Filip Lardon, G Chiappetta, G Natoli, GK Smyth, Guy Van Camp, H Yu, Ilse M. Beck, J Chia, J Lee, J Lee, JB Mitchem, JH Nijwening, JJ Steffan, JT Thaiparambil, K Belguise, K Miyazaki, Karen Heyninck, Karolien De Bosscher, Katarzyna Szarc vel Szic, KD Brown, Ken Declerck, Ken Op de Beeck, L Dumartin, L Ma, LC Mishra, LP Blair, M Endo, M Kaileh, M Tian, Marc Bracke, MD Edmonds, MJ Duffy, MJ Dunning, MN Ndlovu, N Brunner, N Pouliot, N Widodo, O De Wever, P Chi, PH O'Donnell, PJ Boimel, R Nanda, R Santana-Davila, Rajeev Samant, S Mirza, S Ramadoss, S Subbaram, SC Smith, SD Stan, SD Stan, SL Floor, TW Rockway, W Vanden Berghe, Wim Vanden Berghe, WL Berry, WW Bhat, Y He, YJ Surh   +74 more
core   +3 more sources

A Newly Assigned Role of CTCF in Cellular Response to Broken DNAs

Biomolecules, 2021
Best known as a transcriptional factor, CCCTC-binding factor (CTCF) is a highly conserved multifunctional DNA-binding protein with 11 zinc fingers. It functions in diverse genomic processes, including transcriptional activation/repression, insulation ...
Mi Ae Kang, Jong-Soo Lee
doaj   +1 more source