Results 201 to 210 of about 135,955 (287)

Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) maintains muscle progenitor identity by stabilizing the Ppp1r1b-lncRNA-PRC2 complex. [PDF]

Nucleic Acids Res
Kang X, Zhao Y, Nelson SF, Pyle A, Lusis AJ, Touma M.   +5 more
europepmc   +1 more source

CD90 Promotes Gastric Cancer Progression by Regulating SLC1A5‐Mediated Glutamine Metabolism Through YY1

Cancer Science, EarlyView.
The CD90‐YY1‐SLC1A5 axis plays a significant role in gastric cancer. CD90 promotes the binding of YY1 to the SLC1A5 promoter. CD90 regulates SLC1A5‐mediated glutamine metabolism and ferroptosis. ABSTRACT CD90 (THY1) is a cell surface glycoprotein that plays a crucial role in the occurrence and development of various malignant tumors.
Zihua Zhou, Siyi Liu, Chenyu Zhang, Jun Deng, Lin Liang, Yanhong Zhou   +5 more
wiley   +1 more source

Sortilin exhibits tumor suppressor-like activity by limiting EGFR transduction function. [PDF]

Oncogene
Lapeyronnie E, Granet C, Tricard J, Gallet F, Yassine M, Daverat H, Rovini A, Chermat A, Jauberteau MO, Bertin F, Melloni B, Vincent F, Naves T, Lalloué F.   +13 more
europepmc   +1 more source

Super‐Enhancer Formation in Scirrhous Gastric CAFs, and the Presence of a Stromal Field in Non‐Cancerous Tissues

Cancer Science, EarlyView.
While CAFs are produced as a result of education by cancer cells in non‐scirrhous gastric cancer, normal fibroblasts of scirrhous gastric cancer patients are already pre‐conditioned, forming a stromal field for scirrhous gastric cancer. ABSTRACT Scirrhous gastric cancer has aggressive clinical courses and is characterized by dominating cancer ...
Yoshimi Yasukawa, Naoko Hattori, Yu‐Yu Liu, Masayuki Tobo, Genki Yamagishi, Takahiro Irie, Shigeki Sekine, Tohru Kiyono, Satoshi Yamashita, Yukinori Yamagata, Takaki Yoshikawa, Yasuyuki Seto, Toshikazu Ushijima   +12 more
wiley   +1 more source

Integrated analysis of ATAC-seq and RNA-seq reveals the TCP-ARF molecular module related to pathogenic process of phytoplasma infection in Paulownia fortunei. [PDF]

BMC Genomics
Huang S, Li B, Cao Y, Fan G.
europepmc   +1 more source

MAFF Suppresses Necroptosis in Pancreatic Cancer via the GATA4‐MLKL Axis

Cancer Science, EarlyView.
MAFF promotes pancreatic cancer progression by acting as a transcriptional repressor of the GATA4‐MLKL axis, thereby inhibiting necroptotic cell death. This study identifies the MAFF‐GATA4‐MLKL pathway as a novel therapeutic target and a significant prognostic biomarker for pancreatic adenocarcinoma.
Xinwei Zhou, Zheng Zhao, Ning Sun, Daoyong Zhang   +3 more
wiley   +1 more source

Letter to the Editor: Single-cell and multi-omics integrative modeling identifies mitochondrial gene HSPE1 as a therapeutic target in osteosarcoma. [PDF]

J Transl Med
Li X, Liu Y, He H.
europepmc   +1 more source

O‐GlcNAcylation of KAT2A Enhances Bladder Cancer Proliferation by Inhibiting the KAT2A‐TRIM22 Interaction

Cancer Science, EarlyView.
Lysine acetyltransferase 2A (KAT2A) is a transcriptional coactivator and a member of the Histone Acetyltransferase (HAT) family. While altered KAT2A activity has been implicated in various cancers, its role in bladder cancer (BLCA) remains poorly understood.
Wenjie Yang, Zhaoheng Jin, Ziyi Li, Weifeng Xu, Yingjie Li, Yueqiang Peng, Jie Dong, Lin Ma, Zhigang Ji   +8 more
wiley   +1 more source

Blocking SETD2 Enhances the Therapeutic Efficiency of Menin Inhibitor in MLL‐Fusion Leukemia

Cancer Science, EarlyView.
Combined SETD2 and menin inhibitors make synergistic effects against MLL‐fusion leukemia; the combination therapy reduces the expression of target genes through blocking transcription elongation and initiation. ABSTRACT During transcriptional elongation, the histone methyltransferase SETD2 binds to RNA polymerase II and deposits trimethylation marks at
Anpei Li, Yuan Zhang, Ziwei Li, Anhao Liu, Li Zhang, Shubin Gao, Xiao Lin, Xiaoming Liu, Huan Li, Guanghui Jin, Bin Xu   +10 more
wiley   +1 more source

Automated chromatin profiling with spa-ChIP-seq uncovers the impacts of condition variations. [PDF]

Genome Res
Cao Y, Patel L, Alcoser L, Mendenhall E, Benner C, Heinz S, Goren A.   +6 more
europepmc   +1 more source