Results 221 to 230 of about 595,755 (284)

Systematic investigation reveals extensive Epstein-Barr virus transcriptional regulation of the human genome. [PDF]

Cell Genom
Dexheimer PJ, Hass MR, Edsall LE, Diouf AA, Jones SH, Donmez O, Yin C, Dunn KA, Forney C, Hesse HK, VonHandorf A, Chen X, Parameswaran S, Gittens OE, Viel KCMF, Razavi R, Gewurz BE, Zhao B, Lawson LP, Hughes TR, Kottyan LC, Weirauch MT.   +21 more
europepmc   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

TANGO6 coordinates transcription and translation through nucleocytoplasmic partitioning. [PDF]

Sci Adv
Bigliani G, Ballaré C, Wojnacki J, Androulaki S, Guitart T, Blanco E, Foresti O, Lujan A, Ana Y, Gebauer F, Di Croce L, Malhotra V.   +11 more
europepmc   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

MORC1 coordinates TRIM28 interaction and nuclear condensate formation for transposon silencing. [PDF]

iScience
Isota Y, Li P, Sakata K, Chiwata H, Kosako H, Yamanaka S, Ito S, Yamazaki H, Siomi MC.   +8 more
europepmc   +1 more source

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency. [PDF]

Nat Genet
Tao R, Erkek-Ozhan S, Xu B, Matsui Y, Mittal P, Smith KS, Li Y, Filipovic D, Xu R, Gao Q, Darrow E, Kumar R, Djekidel N, Bajpai R, Hadley J, Batts M, Lewis SA, Soliman T, Reilly C, Bhanu NV, Paul L, Lin H, Gudenas B, Lowe K, Zapatka M, Sieber L, Jones DTW, Kool M, Waszak SM, Hovestadt V, Buchhalter I, Ryzhova M, Korshunov A, Lichter P, Chavez L, Kutscher LM, Garcia BA, Pruett-Miller SM, Zhou X, Orr BA, Robinson GW, Wu G, Korbel JO, Peng JC, Pfister SM, Northcott PA.   +45 more
europepmc   +1 more source

Innovation of plant‐derived extracellular vesicles and interdisciplinary research: From discovery to biomedical applications

BMEMat, EarlyView.
Plant‐derived extracellular vesicles offer numerous advantages and are regarded as highly promising candidates in the field of biomedicine. Abstract Extracellular vesicles (EVs) are double‐membrane vesicular structures that can be secreted by nearly all living cells.
Zilin Li, Yi Wei, Ben Hu, Yafang Song, Xiaojia Chen, Nik Ahmad Nizam Nik Malek, Tongkai Chen   +6 more
wiley   +1 more source

Butyrate causes loss of specific acetylation by the histone acetyltransferase p300. [PDF]

iScience
Jiang M, Psoma A, Lyu J, Chiariello MG, Modderman R, Bianchi F, Incarnato D, Marrink SJ, Jonkers IH, van den Bogaart G.   +9 more
europepmc   +1 more source

Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray

ChemFoodChem, EarlyView.
This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi, Adejoke D. Osinubi, Abosede A. Badeji   +2 more
wiley   +1 more source