Results 191 to 200 of about 837,599 (281)

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion. [PDF]

Nat Genet
Aboreden NG, Zhao H, Yang JH, Shan F, Liu F, Hansen AS, Zhang H, Blobel GA.   +7 more
europepmc   +1 more source

Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation. [PDF]

iScience, 2021
Shiimori M, Ichida Y, Nukiwa R, Sakuma T, Abe H, Kajitani R, Fujino Y, Kikuchi A, Kawamura T, Kodama T, Toyooka S, Shirahige K, Schotta G, Kuba K, Itoh T, Imai Y.   +15 more
europepmc   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55–ESCRT‐Associated Vesicular Damage Clearance

Advanced Science, EarlyView.
Oxaliplatin‐resistant colorectal cancer cells utilize a previously unappreciated PLK1‐CEP55‐ESCRT‐driven vesicular extrusion mechanism to clear L‐OHP‐induced cellular damage. The natural withanolide Tubocapsenolide A directly targets and inhibits PLK1 to disrupt this specific damage‐clearance machinery. This blockade induces severe nucleolar stress and
Yueying Yang, Jing Liang, Lu Wang, Hongyan Zhang, Zhiruo Zhang, Yang Liu, Rui Zhu, Wen Xu, Shaohua Xu, Dejuan Sun, Ke Xiang, Yali Wang, Zhimin Fan, Zheng Wang, Hua Li, Lixia Chen   +15 more
wiley   +1 more source

A first-principles quantitative framework for how cohesin regulators shape chromatin loop extrusion. [PDF]

Cell Genom
Huang Z, Liu X, Ding J.
europepmc   +1 more source

Loop, Floyd D. -- 1975-93 -- Correspondence, Individual -- letter, 1990-07-25

, 1990
Letter from Loop, Floyd D. to Sabin, Albert B.
Loop, Floyd D.
core  

Spatiotemporal Computational Meta‐Imager for Broadband Dual‐Layer Optical Convolution

Advanced Science, EarlyView.
A single‐layer polarization‐multiplexed meta‐imager achieves factorized dual‐layer broadband convolution via spatiotemporal kernel decomposition. Fixed Bessel‐vortex bases and time‐sequential liquid‐crystal modulation deliver tunable signed weights and in‐situ fabrication‐error compensation. Experiments verify improved classification performance across
Mengguang Wang, Chenglong Zheng, Huaping Zang, Changwei Zhang, Huai Xia, Chang Wang, Zhenrong Zheng   +6 more
wiley   +1 more source

CTCF-RNA interactions orchestrate cell-specific chromatin loop organization. [PDF]

Sci Adv
Lucero K, Han S, Huang PY, Qiu X, Mazzoni EO, Reinberg D.   +5 more
europepmc   +1 more source

Cohesin chromatin loop formation by an extrinsic motor

, 2023
Guérin TM, Barrington C, Pobegalov G, Molodtsov MI, Uhlmann F.   +4 more
europepmc   +1 more source