Results 211 to 220 of about 94,335 (243)

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source

Genome reorganization and its functional impact during breast cancer progression. [PDF]

Elife
Reed KSM, Fritz A, Greenyer H, Heselmeyer-Haddad K, Frietze S, Stein J, Stein G, Misteli T.   +7 more
europepmc   +1 more source

RepliSage: a stochastic graph-based framework for 3D chromatin modeling across the cell cycle. [PDF]

Nucleic Acids Res
Korsak S, Banecki KH, Agarwal A, Borkowska J, Górski PJ, Chai H, Ruan Y, Buka K, Plewczynski D.   +8 more
europepmc   +1 more source

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Keeping chromatin in the loop(s)

Nature Reviews Molecular Cell Biology, 2021
Eukaryotic chromosomes are huge DNA polymers organized in space and time. Chromatin looping compacts these polymers, helps genome organization by the formation of enhancer–promoter and other interactions, and emerges when genes are highly expressed. Thus, several types of chromatin loops exist, which vary in structure, maintenance and function. Solovei
Leonid A. Mirny, Irina Solovei
openaire   +2 more sources

Mapping chromatin loops in single cells

Trends in Genetics, 2022
Recent advances in high-throughput chromatin conformation capture (Hi-C) technologies at the single-cell level enable the identification of cell type-specific chromatin loops directly from complex tissues. This may help to interpret noncoding variants identified by genome-wide association studies (GWAS) in disease-relevant cell types. We briefly review
Yu, Miao, Hu, Ming, Li, Yun
openaire   +2 more sources

ZNF143 is a regulator of chromatin loop

Cell Biology and Toxicology, 2018
It is known that transcription factor ZNF143 frequently co-binds with CTCF-Cohesin complex in the anchor regions of chromatin loops. However, there is currently no genome-wide experiment to explore the functional roles of ZNF143 in chromatin loops. In this work, we used both computational and experimental analyses to investigate the regulatory effect ...
Zi Wen, Zhi-Tao Huang, Ran Zhang, Cheng Peng   +3 more
openaire   +2 more sources

Chromatin looping and the probability of transcription

Trends in Genetics, 2006
Recent studies of several multigene clusters have shown that gene activation by a remote enhancer is associated with chromatin loop formation. It is not fully understood how a chromatin loop forms in a nucleus or how it is involved in gene regulation. In this article, we propose that the major feature that determines loop formation is the flexibility ...
Qiliang, Li, Gráinne, Barkess, Hong, Qian   +2 more
openaire   +2 more sources

Re-defining the chromatin loop domain

Cytogenetic and Genome Research, 2001
It is commonly accepted that the loop domain represents the basic structural unit of eukaryotic chromatin associated with DNA replication, gene expression and higher order packaging. However, molecular-cytological information defining the loop domain is lacking. There are gaps in our knowledge of the loop structure and how it regulates gene expression.
H H, Heng, S A, Krawetz, W, Lu, S, Bremer, G, Liu, C J, Ye   +5 more
openaire   +2 more sources