Results 251 to 260 of about 800,836 (279)
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Mapping chromatin loops in single cells
Trends in Genetics, 2022Recent advances in high-throughput chromatin conformation capture (Hi-C) technologies at the single-cell level enable the identification of cell type-specific chromatin loops directly from complex tissues. This may help to interpret noncoding variants identified by genome-wide association studies (GWAS) in disease-relevant cell types. We briefly review
Yu, Miao, Hu, Ming, Li, Yun
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Chromatin looping and the probability of transcription
Trends in Genetics, 2006Recent studies of several multigene clusters have shown that gene activation by a remote enhancer is associated with chromatin loop formation. It is not fully understood how a chromatin loop forms in a nucleus or how it is involved in gene regulation. In this article, we propose that the major feature that determines loop formation is the flexibility ...
Qiliang, Li +2 more
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ZNF143 is a regulator of chromatin loop
Cell Biology and Toxicology, 2018It is known that transcription factor ZNF143 frequently co-binds with CTCF-Cohesin complex in the anchor regions of chromatin loops. However, there is currently no genome-wide experiment to explore the functional roles of ZNF143 in chromatin loops. In this work, we used both computational and experimental analyses to investigate the regulatory effect ...
Zi Wen +3 more
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Re-defining the chromatin loop domain
Cytogenetic and Genome Research, 2001It is commonly accepted that the loop domain represents the basic structural unit of eukaryotic chromatin associated with DNA replication, gene expression and higher order packaging. However, molecular-cytological information defining the loop domain is lacking. There are gaps in our knowledge of the loop structure and how it regulates gene expression.
H H, Heng +5 more
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Analysis of Chromatin Interaction and Accessibility by Trac-Looping
2023Spatial organization of the genome modulates pivotal biological processes. The emerging new technologies have provided novel insights into genome structure and its role in regulating cell activities. To examine the genome-wide chromatin interactions at accessible chromatin regions, we developed a DNA transposase-mediated analysis of chromatin looping ...
Shuai, Liu, Qingsong, Tang, Keji, Zhao
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BIOLOGICAL CONSEQUENCES OF CHROMATIN LOOPING IN PERICENTRIC CHROMATIN
2018During mitosis, replicated sister chromatids are attached to opposite sides of a microtubule spindle at their centromeres in a process called biorientation. The proteinaceous structure that links centromeres, a region of the chromosome, to the spindle is called the kinetochore.
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Chromatin loops, illegitimate recombination, and genome evolution
BioEssays, 2009AbstractChromosomal rearrangements frequently occur at specific places (“hot spots”) in the genome. These recombination hot spots are usually separated by 50–100 kb regions of DNA that are rarely involved in rearrangements. It is quite likely that there is a correlation between the above‐mentioned distances and the average size of DNA loops fixed at ...
Omar L, Kantidze, Sergey V, Razin
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Chromatin loops and transcriptional regulation.
Critical reviews in eukaryotic gene expression, 1992The existence of a supermolecular structure in the eukaryotic nucleus, involving loops of chromatin attached at irregularly spaced points to the nuclear matrix, is now well established. Quite a bit is known concerning the DNA sequences involved in the attachment. However, the function of this highly organized structure remains largely unknown.
J S, Zlatanova, K E, van Holde
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Theory of chromatin organization maintained by active loop extrusion
Proceedings of the National Academy of Sciences of the United States of America, 2023Michael Rubinstein, Brian Chan
exaly