Results 71 to 80 of about 800,836 (279)

Non-specific interactions are sufficient to explain the position of heterochromatic chromocenters and nucleoli in interphase nuclei [PDF]

, 2009
The organization of the eukaryote nucleus into functional compartments arises by self-organization both through specific protein–protein and protein–DNA interactions and non-specific interactions that lead to entropic effects, such as e.g.
Nooijer, S., de, Bisseling, T., Wellink, J., de Nooijer, S., Mulder, B.   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

SATB1 Mediates Long-Range Chromatin Interactions: A Dual Regulator of Anti-Apoptotic BCL2 and Pro-Apoptotic NOXA Genes. [PDF]

PLoS ONE, 2015
Aberrant expression of special AT-rich binding protein 1 (SATB1), a global genomic organizer, has been associated with various cancers, which raises the question of how higher-order chromatin structure contributes to carcinogenesis.
Yin Yang, Zongdan Wang, Luan Sun, Lipei Shao, Nan Yang, Dawei Yu, Xin Zhang, Xiao Han, Yujie Sun   +8 more
doaj   +1 more source

The Adenomatous Polyposis Coli protein contributes to normal compaction of mitotic chromatin [PDF]

, 2012
The tumour suppressor <i>Adenomatous Polyposis Coli</i> (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood.
Newton, Ian P., Nathke, Inke S.; id_orcid, Ashwat Visvanathan, Daniel Klotz (158368), Inke S Näthke, Visvanathan, Ashwat, Gaganmeet S. Chadha (158365), Klotz Daniel, Swedlow, Jason R.; id_orcid, Visvanathan, A., Näthke, I.S., Chadha, Gaganmeet S., Gaganmeet S Chadha, Lamond Angus, Angus Lamond (158376), Dikovskaya Dina, Visvanathan Ashwat, Dikovskaya, Dina, Näthke Inke S., Lamond, A., Swedlow Jason R., Dina Dikovskaya (158354), Jason R. Swedlow (158382), Inke S. Näthke (158386), Newton Ian P., Lamond, Angus; id_orcid, Newton, I.P., Khoudoli, Guennadi, Khoudoli, G., Angus Lamond, Guennadi Khoudoli (158358), Dikovskaya, D., Daniel Klotz, Klotz, D., Jason R Swedlow, Khoudoli Guennadi, Chadha, G.S., Guennadi Khoudoli, Klotz, Daniel, Dina Dikovskaya, Ian P. Newton (158362), Chadha Gaganmeet S., Ashwat Visvanathan (158372), Swedlow, J.R., Ian P Newton   +44 more
core   +1 more source

Wonderful news - As of June 2023 Scots poet and former Makar Jackie Kay is a patron of Loop!!!

, 2023
Jackie Kay was born and brought up in Scotland. She is the author of—among other books—The Adoption Papers, which won the Forward Prize, Red Dust Road, winner of the Scottish Book of the Year Award, Trumpet, and the Costa-shortlisted Fiere.
The LOOP team
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

NoRC, a novel chromatin remodeling complex involved in ribosomal RNA gene silencing [PDF]

, 2004
Regulation of gene expression takes place in the nucleus in a highly structured and condensed nucleoprotein environment, called chromatin (Felsenfeld and Groudine, 2003; Khorasanizadeh, 2004; Vaquero et al., 2003).
Strohner, Ralf
core   +1 more source

Active loop extrusion modulates the mechanical response of chromatin under tension

Physical Review Research
Chromosomes are complex biopolymers folded into dynamic loops via a loop-extrusion process and may experience various mechanical forces in vivo. We develop a force-dependent model of chromatin loop extrusion and investigate its mechanical consequences on
Hossein Salari, Daniel Jost
doaj   +1 more source

Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner

eLife, 2020
Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been proposed as a mechanism to organize chromatin in interphase and metaphase. However, the requirements for chromatin organization in these cell cycle phases are different, and
Stefan Golfier, Thomas Quail, Hiroshi Kimura, Jan Brugués   +3 more
doaj   +1 more source

R-loop: an emerging regulator of chromatin dynamics [PDF]

Acta Biochimica et Biophysica Sinica, 2016
The dynamic structure of chromatin, which exists in two conformational states: heterochromatin and euchromatin, alters the accessibility of the DNA to regulatory factors during transcription, replication, recombination, and DNA damage repair. Chemical modifications of histones and DNA, as well as adenosine triphospahate-dependent nucleosome remodeling,
Qais, Al-Hadid, Yanzhong, Yang
openaire   +2 more sources