Results 51 to 60 of about 800,836 (279)

SATB1-mediated functional packaging of chromatin into loops [PDF]

Methods, 2012
Mammalian genomes are organized into multiple layers of higher-order chromatin structure, and in this organization chromatin looping is a striking and crucial feature that brings together distal genomic loci into close spatial proximity. Such three-dimensional organization of chromatin has been suggested to be functionally important in gene regulation.
Kohwi-Shigematsu, Terumi, Kohwi, Yoshinori, Takahashi, Keiko, Richards, Hunter W, Ayers, Stephen D, Han, Hye-Jung, Cai, Shutao   +6 more
openaire   +4 more sources

Back-spliced RNA from retrotransposon binds to centromere and regulates centromeric chromatin loops in maize.

PLoS Biology, 2020
In most plants, centromeric DNA contains highly repetitive sequences, including tandem repeats and retrotransposons; however, the roles of these sequences in the structure and function of the centromere are unclear.
Yalin Liu, Handong Su, Jing Zhang, Yang Liu, Chao Feng, Fangpu Han   +5 more
doaj   +1 more source

UnionLoops: a workflow for calling chromatin loops across related Hi-C datasets with improved specificity, precision, and sensitivity

Genome Biology
Chromatin loop calling from chromatin interaction data often exhibits substantial variability across related samples. We present UnionLoops, a computational workflow for chromatin loop calling across multiple related samples.
Jiangyuan Liu, Johan H. Gibcus, Job Dekker   +2 more
doaj   +1 more source

A SWI/SNF Chromatin Remodelling Protein Controls Cytokinin Production through the Regulation of Chromatin Architecture. [PDF]

PLoS ONE, 2015
Chromatin architecture determines transcriptional accessibility to DNA and consequently gene expression levels in response to developmental and environmental stimuli.
Teddy Jégu, Séverine Domenichini, Thomas Blein, Federico Ariel, Aurélie Christ, Soon-Kap Kim, Martin Crespi, Stéphanie Boutet-Mercey, Grégory Mouille, Mickaël Bourge, Heribert Hirt, Catherine Bergounioux, Cécile Raynaud, Moussa Benhamed   +13 more
doaj   +1 more source

Analysis of β-globin chromatin micro-environment using a novel 3C variant, 4Cv [PDF]

, 2010
Copyright: © 2010 Pink et al.Higher order chromatin folding is critical to a number of developmental processes, including the regulation of gene expression.
Christopher H Eskiw, Christopher H. Eskiw, David R F Carter, Eskiw, CH, Daniel P Caley, Pink Ryan C., David R. F. Carter, Caley, DP, Ryan C Pink, Caley, D, Carter, D, Daniel P. Caley, Eskiw Christopher H., Caley Daniel P., Pink, R, Ryan C. Pink, Eskiw, C, Carter David R. F.   +17 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Identification and validation of transcription factors that regulate chromatin dynamics [PDF]

, 2012
Gene expression has to be tightly regulated during all cellular processes. During embryonic development differentiating cells loose their developmental potential and acquire specific functions by activating lineage-specific genes.
Schöler, Anne
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

CRISPR-Mediated Reorganization of Chromatin Loop Structure. [PDF]

J Vis Exp, 2018
Recent studies have clearly shown that long-range, three-dimensional chromatin looping interactions play a significant role in the regulation of gene expression, but whether looping is responsible for or a result of alterations in gene expression is still unknown.
Morgan SL, Chang EY, Mariano NC, Bermudez A, Arruda NL, Wu F, Luo Y, Shankar G, Huynh SK, Huang CC, Pitteri SJ, Wang KC.   +11 more
europepmc   +4 more sources

Kinetic control of eukaryotic chromatin structure by recursive topological restraints [PDF]

, 2008
Chromatin structure undergoes many changes during the cell cycle and in response to regulatory events. A basic unit of chromatin organization is the nucleosome core particle.
Dominika Borek, Zbyszek Otwinowski
core