Results 41 to 50 of about 800,836 (279)
Chromatin Switches and Loops [PDF]
Cell, 2013 In the realm of gene expression, as in real estate, location is key. In this Select, we present two cases in which a specific histone modification causes changes to the local chromatin architecture, in turn impacting nearby gene regulation, and an example of how the spatial organization of loci creates an environment that leads to coregulation of ...
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Diffusion Based Looping of Chromatin [PDF]
Biophysical Journal, 2010 Chromatin folding inside the interphase nucleus of eukaryotic cells is done on multiple scales of length and time. Despite recent progress in understanding the folding motifs of chromatin, the higher-order folding still remains elusive. Flourescent in situ hybridization reveals a tight connection between genome folding and function as well as a folding
Heermann, Dieter W., Bohn, Manfred
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Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]
, 2005 The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton +2 more
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R-loop resolution promotes co-transcriptional chromatin silencing
Nature Communications, 2021 Nascent non-coding RNA can mediate chromatin silencing, however mechanistically this process is poorly understood. Here the authors show that resolution of an R-loop during 3'-end processing of a plant antisense transcript recruits chromatin modifiers to
Congyao Xu +5 more
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Function of the upstream activating factor in chromatin structure organization and transcriptional regulation at the yeast ribosomal DNA [PDF]
, 2010 Chromatin is the template of all processes involved in DNA metabolism in the eukaryotic cell. Accordingly, chromatin is a dynamic structure which changes in its composition and posttranslational modification correlating with the functional state of a ...
Götze, Hannah
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Effective blocking of the white enhancer requires cooperation between two main mechanisms suggested for the insulator function. [PDF]
PLoS Genetics, 2013 Chromatin insulators block the action of transcriptional enhancers when interposed between an enhancer and a promoter. In this study, we examined the role of chromatin loops formed by two unrelated insulators, gypsy and Fab-7, in their enhancer-blocking ...
Olga Kyrchanova +6 more
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Chromatin: A Connection Between Loops and Barriers? [PDF]
Current Biology, 2002 A genetic screen for proteins that can block the spread of silenced heterochromatin has identified components of the nuclear pores with potential barrier activity. These results suggest that formation of loops of chromatin anchored to the pore could be one mechanism of barrier function.
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Pericentric Chromatin Is Organized into an Intramolecular Loop in Mitosis [PDF]
Current Biology, 2008 Cohesin proteins link sister chromatids and provide the basis for tension between bi-oriented sister chomatids in mitosis. Cohesin is concentrated at the centromere region of the chromosome despite the fact that sister centromeres can be separated by 800nm in vivo. The function of cohesin at sites of separated DNA is unknown.
Yeh, Elaine +7 more
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Smc1ß determines meiotic chromatin axis loop organization
, 2008 Meiotic chromosomes consist of proteinaceous axial structures from which chromatin loops emerge. Although we know that loop density along the meiotic chromosome axis is conserved in organisms with different genome sizes, the basis for the regular spacing
Jessberger, R. +23 more
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3DPolyS-LE: an accessible simulation framework to model the interplay between chromatin and loop extrusion [PDF]
, 2022 International audienceAbstract Motivation Recent studies suggest that the loop extrusion activity of Structural Maintenance of Chromosomes complexes is central to proper organization of genomes in vivo .
Gitchev, Todor +3 more
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