Results 41 to 50 of about 837,599 (281)

Chromatin loops, gene positioning, and gene expression [PDF]

Frontiers in Genetics, 2012
Technological developments and intense research over the last years have led to a better understanding of the 3D structure of the genome and its influence on genome function inside the cell nucleus. We will summarize topological studies performed on four model gene loci: the α- and β-globin gene loci, the antigen receptor loci, the imprinted H19-Igf2 ...
Holwerda, Sjoerd, Laat, Wouter de
openaire   +4 more sources

Cohesin, condensin, and the intramolecular centromere loop together generate the mitotic chromatin spring [PDF]

, 2011
Sister chromatid cohesion provides the mechanistic basis, together with spindle microtubules, for generating tension between bioriented chromosomes in metaphase.
Haase, Julian, Bloom, Kerry, Julian Haase, Russell M. Taylor, Kerry Bloom, Vicci, Leandra, Leandra Vicci, Taylor, Russell M., Andrew D. Stephens, Stephens, Andrew D.   +9 more
core   +1 more source

Chromatin Switches and Loops [PDF]

Cell, 2013
In the realm of gene expression, as in real estate, location is key. In this Select, we present two cases in which a specific histone modification causes changes to the local chromatin architecture, in turn impacting nearby gene regulation, and an example of how the spatial organization of loci creates an environment that leads to coregulation of ...
openaire   +1 more source

R-loop resolution promotes co-transcriptional chromatin silencing

Nature Communications, 2021
Nascent non-coding RNA can mediate chromatin silencing, however mechanistically this process is poorly understood. Here the authors show that resolution of an R-loop during 3'-end processing of a plant antisense transcript recruits chromatin modifiers to
Congyao Xu, Zhe Wu, Hong-Chao Duan, Xiaofeng Fang, Guifang Jia, Caroline Dean   +5 more
doaj   +1 more source

Diffusion Based Looping of Chromatin [PDF]

Biophysical Journal, 2010
Chromatin folding inside the interphase nucleus of eukaryotic cells is done on multiple scales of length and time. Despite recent progress in understanding the folding motifs of chromatin, the higher-order folding still remains elusive. Flourescent in situ hybridization reveals a tight connection between genome folding and function as well as a folding
Heermann, Dieter W., Bohn, Manfred
openaire   +1 more source

Function of the upstream activating factor in chromatin structure organization and transcriptional regulation at the yeast ribosomal DNA [PDF]

, 2010
Chromatin is the template of all processes involved in DNA metabolism in the eukaryotic cell. Accordingly, chromatin is a dynamic structure which changes in its composition and posttranslational modification correlating with the functional state of a ...
Götze, Hannah
core   +1 more source

The Adenomatous Polyposis Coli protein contributes to normal compaction of mitotic chromatin [PDF]

, 2012
The tumour suppressor <i>Adenomatous Polyposis Coli</i> (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood.
Newton, Ian P., Nathke, Inke S.; id_orcid, Ashwat Visvanathan, Daniel Klotz (158368), Inke S Näthke, Visvanathan, Ashwat, Gaganmeet S. Chadha (158365), Klotz Daniel, Swedlow, Jason R.; id_orcid, Visvanathan, A., Näthke, I.S., Chadha, Gaganmeet S., Gaganmeet S Chadha, Lamond Angus, Angus Lamond (158376), Dikovskaya Dina, Visvanathan Ashwat, Dikovskaya, Dina, Näthke Inke S., Lamond, A., Swedlow Jason R., Dina Dikovskaya (158354), Jason R. Swedlow (158382), Inke S. Näthke (158386), Newton Ian P., Lamond, Angus; id_orcid, Newton, I.P., Khoudoli, Guennadi, Khoudoli, G., Angus Lamond, Guennadi Khoudoli (158358), Dikovskaya, D., Daniel Klotz, Klotz, D., Jason R Swedlow, Khoudoli Guennadi, Chadha, G.S., Guennadi Khoudoli, Klotz, Daniel, Dina Dikovskaya, Ian P. Newton (158362), Chadha Gaganmeet S., Ashwat Visvanathan (158372), Swedlow, J.R., Ian P Newton   +44 more
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MMCT-Loop: a mix model-based pipeline for calling targeted 3D chromatin loops

, 2023
Protein-specific Chromatin Conformation Capture (3C)-based technologies have become essential for identifying distal genomic interactions with critical roles in gene regulation. The standard techniques include Chromatin Interaction Analysis by Paired-End
Li Tang (17116978)
core   +1 more source

Effective blocking of the white enhancer requires cooperation between two main mechanisms suggested for the insulator function. [PDF]

PLoS Genetics, 2013
Chromatin insulators block the action of transcriptional enhancers when interposed between an enhancer and a promoter. In this study, we examined the role of chromatin loops formed by two unrelated insulators, gypsy and Fab-7, in their enhancer-blocking ...
Olga Kyrchanova, Oksana Maksimenko, Viacheslav Stakhov, Tatyana Ivlieva, Alexander Parshikov, Vasily M Studitsky, Pavel Georgiev   +6 more
doaj   +1 more source

R-loop: an emerging regulator of chromatin dynamics [PDF]

Acta Biochimica et Biophysica Sinica, 2016
The dynamic structure of chromatin, which exists in two conformational states: heterochromatin and euchromatin, alters the accessibility of the DNA to regulatory factors during transcription, replication, recombination, and DNA damage repair. Chemical modifications of histones and DNA, as well as adenosine triphospahate-dependent nucleosome remodeling,
Qais, Al-Hadid, Yanzhong, Yang
openaire   +2 more sources