Results 41 to 50 of about 94,335 (243)
Effective blocking of the white enhancer requires cooperation between two main mechanisms suggested for the insulator function. [PDF]
PLoS Genetics, 2013 Chromatin insulators block the action of transcriptional enhancers when interposed between an enhancer and a promoter. In this study, we examined the role of chromatin loops formed by two unrelated insulators, gypsy and Fab-7, in their enhancer-blocking ...
Olga Kyrchanova +6 more
doaj +1 more source
Chromatin: A Connection Between Loops and Barriers? [PDF]
Current Biology, 2002 A genetic screen for proteins that can block the spread of silenced heterochromatin has identified components of the nuclear pores with potential barrier activity. These results suggest that formation of loops of chromatin anchored to the pore could be one mechanism of barrier function.
openaire +2 more sources
R-loop: an emerging regulator of chromatin dynamics [PDF]
Acta Biochimica et Biophysica Sinica, 2016 The dynamic structure of chromatin, which exists in two conformational states: heterochromatin and euchromatin, alters the accessibility of the DNA to regulatory factors during transcription, replication, recombination, and DNA damage repair. Chemical modifications of histones and DNA, as well as adenosine triphospahate-dependent nucleosome remodeling,
Qais, Al-Hadid, Yanzhong, Yang
openaire +2 more sources
PLoS Biology, 2020 In most plants, centromeric DNA contains highly repetitive sequences, including tandem repeats and retrotransposons; however, the roles of these sequences in the structure and function of the centromere are unclear.
Yalin Liu +5 more
doaj +1 more source
A SWI/SNF Chromatin Remodelling Protein Controls Cytokinin Production through the Regulation of Chromatin Architecture. [PDF]
PLoS ONE, 2015 Chromatin architecture determines transcriptional accessibility to DNA and consequently gene expression levels in response to developmental and environmental stimuli.
Teddy Jégu +13 more
doaj +1 more source
iScience, 2022 Summary: The chromatin loop plays a critical role in the study of gene expression and disease. Supervised learning-based algorithms to predict the chromatin loops require large priori information to satisfy the model construction, while the prediction ...
Yajing Deng +4 more
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Loop Interrupted: Dysfunctional Chromatin Relations in Neurological Diseases
Frontiers in Genetics, 2021 The majority of genetic variants for psychiatric disorders have been found within non-coding genomic regions. Physical interactions of gene promoters with distant regulatory elements carrying risk alleles may explain how the latter affect gene expression.
Marthe Behrends, Olivia Engmann
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
BET family BRD3 initiates DSB-induced chromatin remodeling with TIP60 to promote R-loop-mediated HR
Cell ReportsSummary: Mechanisms for genome stability in actively transcribed regions are essential for cellular homeostasis; however, these mechanisms are poorly understood. Herein, we identify the bromodomain and extraterminal domain (BET) family BRD3 as the genome
Jianghao Qian +11 more
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TAD cliques predict key features of chromatin organization
BMC Genomics, 2021 Background Mechanisms underlying genome 3D organization and domain formation in the mammalian nucleus are not completely understood. Multiple processes such as transcriptional compartmentalization, DNA loop extrusion and interactions with the nuclear ...
Tharvesh M. Liyakat Ali +3 more
doaj +1 more source