Results 31 to 40 of about 800,836 (279)

Pharmacologic control of chromatin looping [PDF]

Blood, 2015
In this issue of Blood , [Krivega et al][1] establish a new method to reactivate fetal hemoglobin (HbF) production in adult human erythroid cells through pharmacologic manipulation of chromatin looping at the β-globin locus.[1][2] ![Figure][3] Different approaches to reactivate fetal γ-
openaire   +2 more sources

Histone methylation by PRC2 is inhibited by active chromatin marks [PDF]

, 2013
Chromatin modifiers serve as regulatory switches that control the cell cycle, maintain pluripotency and drive differentiation and development. Positive feedback mechanisms help to pass on transcriptional information from one generation of cells to the ...
Schmitges, Frank W.
core   +1 more source

HiCoP, a simple and robust method for detecting interactions of regulatory regions

Epigenetics & Chromatin, 2020
Background Chromatin physical interactions provide essential information for understanding the regulation of cis-elements like enhancers, promoters, and insulators in cell development and differentiation. The Hi-C assay is a technique detecting chromatin
Yan Zhang, Zhaoqiang Li, Shasha Bian, Hao Zhao, Delong Feng, Yanhong Chen, Yuhe Hou, Qifa Liu, Bingtao Hao   +8 more
doaj   +1 more source

Proteomic interrogation of human chromatin. [PDF]

, 2011
Chromatin proteins provide a scaffold for DNA packaging and a basis for epigenetic regulation and genomic maintenance. Despite understanding its functional roles, mapping the chromatin proteome (i.e. the "Chromatome") is still a continuing process. Here,
LeRoy, Gary, Christodoulos A Floudas, Floudas, Christodoulos A., Barry M Zee, Garcia, Benjamin A., Richard C Baliban, Baliban, Richard C., Sandra B Hake, Torrente, Mariana P., Zee, Barry M., Hake, Sandra B., Christodoulos A. Floudas, Barry M. Zee, Nicolas L. Young, Mariana P. Torrente, Gary LeRoy, Richard C. Baliban, Sandra B. Hake, Benjamin A. Garcia, Nicolas L Young, Benjamin A Garcia, Young, Nicolas L., Mariana P Torrente   +22 more
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Chromosome organization by one-sided and two-sided loop extrusion

eLife, 2020
SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and progressively growing DNA loops.
Edward J Banigan, Aafke A van den Berg, Hugo B Brandão, John F Marko, Leonid A Mirny   +4 more
doaj   +1 more source

EBV latency types adopt alternative chromatin conformations. [PDF]

PLoS Pathogens, 2011
Epstein-Barr Virus (EBV) can establish latent infections with distinct gene expression patterns referred to as latency types. These different latency types are epigenetically stable and correspond to different promoter utilization.
Italo Tempera, Michael Klichinsky, Paul M Lieberman   +2 more
doaj   +1 more source

Insight Into Chromatin-Enriched RNA: A Key Chromatin Regulator in Tumors

Frontiers in Cell and Developmental Biology, 2021
Chromatin-enriched RNAs (cheRNAs) constitute a special class of long noncoding RNAs (lncRNAs) that are enriched around chromatin and function to activate neighboring or distal gene transcription.
Jixing Zhang, Jixing Zhang, Tianyi Ding, Tianyi Ding, He Zhang, He Zhang   +5 more
doaj   +1 more source

Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc [PDF]

, 2009
HP1 is a major component of chromatin and regulates gene expression through its binding to methylated histone H3. Most eukaryotes express at least three isoforms of HP1 with similar domain architecture.
Eskeland, Ragnhild, RAFFA, GRAZIA DANIELA, Eskeland Ragnhild, Abel, Jochen, Jochen Abel, Raffa Grazia D., Raffa, Grazia D, Ragnhild Eskeland, Abel Jochen, Kremmer Elisabeth, Abel, J., Imhof Axel, Raffa, G.D., Ragnhild Eskel, Imhof, Axel, Eskeland, R., Grazia D. Raffa, Kremmer, E., Imhof, A., Kremmer, Elisabeth, Axel Imhof, Grazia D Raffa, Elisabeth Kremmer   +22 more
core   +1 more source

Expression-dependent folding of interphase chromatin. [PDF]

PLoS ONE, 2012
Multiple studies suggest that chromatin looping might play a crucial role in organizing eukaryotic genomes. To investigate the interplay between the conformation of interphase chromatin and its transcriptional activity, we include information from gene ...
Hansjoerg Jerabek, Dieter W Heermann
doaj   +1 more source

Chromatin loops, gene positioning, and gene expression [PDF]

Frontiers in Genetics, 2012
Technological developments and intense research over the last years have led to a better understanding of the 3D structure of the genome and its influence on genome function inside the cell nucleus. We will summarize topological studies performed on four model gene loci: the α- and β-globin gene loci, the antigen receptor loci, the imprinted H19-Igf2 ...
Holwerda, Sjoerd, Laat, Wouter de
openaire   +4 more sources