Results 31 to 40 of about 94,335 (243)
Insight Into Chromatin-Enriched RNA: A Key Chromatin Regulator in Tumors
Frontiers in Cell and Developmental Biology, 2021 Chromatin-enriched RNAs (cheRNAs) constitute a special class of long noncoding RNAs (lncRNAs) that are enriched around chromatin and function to activate neighboring or distal gene transcription.
Jixing Zhang +5 more
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The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension
Cell, 2017 Bas Van Steensel +2 more
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Expression-dependent folding of interphase chromatin. [PDF]
PLoS ONE, 2012 Multiple studies suggest that chromatin looping might play a crucial role in organizing eukaryotic genomes. To investigate the interplay between the conformation of interphase chromatin and its transcriptional activity, we include information from gene ...
Hansjoerg Jerabek, Dieter W Heermann
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The attachments of chromatin loops to the nucleoskeleton
Cell Biology International Reports, 1992 It is widely assumed by cell biologists that chromatin is looped by attachment to some nuclear skeleton. 'Structural' attachments might be mediated through specific sequences; these would be attached in most cells in an organism, underlying the basic structure of the mitotic chromosome and persisting throughout interphase.
Jackson, D +3 more
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Pharmacologic control of chromatin looping [PDF]
Blood, 2015 In this issue of Blood , [Krivega et al][1] establish a new method to reactivate fetal hemoglobin (HbF) production in adult human erythroid cells through pharmacologic manipulation of chromatin looping at the β-globin locus.[1][2] ![Figure][3] Different approaches to reactivate fetal γ-
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Chromatin loops, gene positioning, and gene expression [PDF]
Frontiers in Genetics, 2012 Technological developments and intense research over the last years have led to a better understanding of the 3D structure of the genome and its influence on genome function inside the cell nucleus. We will summarize topological studies performed on four model gene loci: the α- and β-globin gene loci, the antigen receptor loci, the imprinted H19-Igf2 ...
Holwerda, Sjoerd, Laat, Wouter de
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Chromatin Switches and Loops [PDF]
Cell, 2013 In the realm of gene expression, as in real estate, location is key. In this Select, we present two cases in which a specific histone modification causes changes to the local chromatin architecture, in turn impacting nearby gene regulation, and an example of how the spatial organization of loci creates an environment that leads to coregulation of ...
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R-loop resolution promotes co-transcriptional chromatin silencing
Nature Communications, 2021 Nascent non-coding RNA can mediate chromatin silencing, however mechanistically this process is poorly understood. Here the authors show that resolution of an R-loop during 3'-end processing of a plant antisense transcript recruits chromatin modifiers to
Congyao Xu +5 more
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CRISPR-Mediated Reorganization of Chromatin Loop Structure. [PDF]
J Vis Exp, 2018 Recent studies have clearly shown that long-range, three-dimensional chromatin looping interactions play a significant role in the regulation of gene expression, but whether looping is responsible for or a result of alterations in gene expression is still unknown.
Morgan SL +11 more
europepmc +4 more sources
Diffusion Based Looping of Chromatin [PDF]
Biophysical Journal, 2010 Chromatin folding inside the interphase nucleus of eukaryotic cells is done on multiple scales of length and time. Despite recent progress in understanding the folding motifs of chromatin, the higher-order folding still remains elusive. Flourescent in situ hybridization reveals a tight connection between genome folding and function as well as a folding
Heermann, Dieter W., Bohn, Manfred
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