Results 21 to 30 of about 837,599 (281)
Anchoring Chromatin Loops to Cancer [PDF]
Developmental Cell, 2017 Although some genomic rearrangements are caused by replication or transcription, the etiology of others is unclear. Reporting in Cell, Canela et al. (2017) reveal that type II topoisomerase-mediated release of torsional strain at chromosomal loop anchors generates DNA double-strand breaks that drive multiple oncogenic translocations in a transcription ...
Faith, Fowler, Jessica K, Tyler
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Evolution of Regulated Transcription
Cells, 2020 The genomes of all organisms abound with various cis-regulatory elements, which control gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and are DNA regions that form physical contacts with gene promoters and ...
Oleg V. Bylino +2 more
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3DPolyS-LE: an accessible simulation framework to model the interplay between chromatin and loop extrusion [PDF]
, 2022 International audienceAbstract Motivation Recent studies suggest that the loop extrusion activity of Structural Maintenance of Chromosomes complexes is central to proper organization of genomes in vivo .
Gitchev, Todor +7 more
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Epigenetics & Chromatin, 2020 Transcriptional repression of Nanog is an important hallmark of stem cell differentiation. Chromatin modifications have been linked to the epigenetic profile of the Nanog gene, but whether chromatin organization actually plays a causal role in Nanog ...
Francisco J. González-Rico +8 more
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Short‐range regulatory chromatin loops in plants [PDF]
New Phytologist, 2020 SummaryIn all eukaryotic organisms, gene expression correlates with the condensation state of the chromatin. Highly packed genome regions, known as heterochromatins, are associated with repressed loci, whereas euchromatic regions represent a relaxed state of the chromatin actively transcribed. However, even in these active regions, associations between
Delfina Gagliardi, Pablo A. Manavella
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Closed chromatin loops at the ends of chromosomes [PDF]
The Journal of Cell Biology, 2004 The termini of eukaryotic chromosomes contain specialized protective structures, the telomeres, composed of TTAGGG repeats and associated proteins which, together with telomerase, control telomere length. Telomere shortening is associated with senescence and inappropriate telomerase activity may lead to cancer.
Nikitina, Tatiana +1 more
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Loops and the activity of loop extrusion factors constrain chromatin dynamics [PDF]
Molecular Biology of the Cell, 2020 The relationship between chromatin structure and dynamics is incompletely understood. Here experimental and computational approaches are combined to reveal that looping interactions impose constraints on chromatin mobility while the ATP-dependent INO80 chromatin remodeler plays an important role in energy-dependent chromatin dynamics.
Mary Lou P. Bailey +8 more
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Histone methylation by PRC2 is inhibited by active chromatin marks [PDF]
, 2013 Chromatin modifiers serve as regulatory switches that control the cell cycle, maintain pluripotency and drive differentiation and development. Positive feedback mechanisms help to pass on transcriptional information from one generation of cells to the ...
Schmitges, Frank W.
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The role of chromatin loop extrusion in antibody diversification. [PDF]
Nat Rev Immunol, 2022 Cohesin mediates chromatin loop formation across the genome by extruding chromatin between convergently oriented CTCF-binding elements. Recent studies indicate that cohesin-mediated loop extrusion in developing B cells presents immunoglobulin heavy chain (Igh) variable (V), diversity (D) and joining (J) gene segments to RAG endonuclease through a ...
Zhang Y, Zhang X, Dai HQ, Hu H, Alt FW.
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Chromatin looping is needed for iPSC induction [PDF]
Cell Cycle, 2013 Terminally differentiated somatic cells can be reset to pluripotent capability either by ectopic expression of defined factors to form so-called “induced pluripotent stem cells” (iPSCs)1 or by empl...
Hu, Ji-Fan, Hoffman, Andrew R
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