Results 21 to 30 of about 94,335 (243)
Prediction of CTCF loop anchor based on machine learning
Frontiers in Genetics, 2023 Introduction: Various activities in biological cells are affected by three-dimensional genome structure. The insulators play an important role in the organization of higher-order structure.
Xiao Zhang +7 more
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Epigenetics & Chromatin, 2020 Transcriptional repression of Nanog is an important hallmark of stem cell differentiation. Chromatin modifications have been linked to the epigenetic profile of the Nanog gene, but whether chromatin organization actually plays a causal role in Nanog ...
Francisco J. González-Rico +8 more
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Evolution of Regulated Transcription
Cells, 2020 The genomes of all organisms abound with various cis-regulatory elements, which control gene activity. Transcriptional enhancers are a key group of such elements in eukaryotes and are DNA regions that form physical contacts with gene promoters and ...
Oleg V. Bylino +2 more
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Short‐range regulatory chromatin loops in plants [PDF]
New Phytologist, 2020 SummaryIn all eukaryotic organisms, gene expression correlates with the condensation state of the chromatin. Highly packed genome regions, known as heterochromatins, are associated with repressed loci, whereas euchromatic regions represent a relaxed state of the chromatin actively transcribed. However, even in these active regions, associations between
Delfina Gagliardi, Pablo A. Manavella
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Closed chromatin loops at the ends of chromosomes [PDF]
The Journal of Cell Biology, 2004 The termini of eukaryotic chromosomes contain specialized protective structures, the telomeres, composed of TTAGGG repeats and associated proteins which, together with telomerase, control telomere length. Telomere shortening is associated with senescence and inappropriate telomerase activity may lead to cancer.
Nikitina, Tatiana +1 more
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Loops and the activity of loop extrusion factors constrain chromatin dynamics [PDF]
Molecular Biology of the Cell, 2020 The relationship between chromatin structure and dynamics is incompletely understood. Here experimental and computational approaches are combined to reveal that looping interactions impose constraints on chromatin mobility while the ATP-dependent INO80 chromatin remodeler plays an important role in energy-dependent chromatin dynamics.
Mary Lou P. Bailey +8 more
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Chromosome organization by one-sided and two-sided loop extrusion
eLife, 2020 SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and progressively growing DNA loops.
Edward J Banigan +4 more
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EBV latency types adopt alternative chromatin conformations. [PDF]
PLoS Pathogens, 2011 Epstein-Barr Virus (EBV) can establish latent infections with distinct gene expression patterns referred to as latency types. These different latency types are epigenetically stable and correspond to different promoter utilization.
Italo Tempera +2 more
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Chromatin looping is needed for iPSC induction [PDF]
Cell Cycle, 2013 Terminally differentiated somatic cells can be reset to pluripotent capability either by ectopic expression of defined factors to form so-called “induced pluripotent stem cells” (iPSCs)1 or by empl...
Hu, Ji-Fan, Hoffman, Andrew R
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HiCoP, a simple and robust method for detecting interactions of regulatory regions
Epigenetics & Chromatin, 2020 Background Chromatin physical interactions provide essential information for understanding the regulation of cis-elements like enhancers, promoters, and insulators in cell development and differentiation. The Hi-C assay is a technique detecting chromatin
Yan Zhang +8 more
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