Results 151 to 160 of about 39,377 (243)

Identification of chromatin loops from Hi-C interaction matrices by CTCF-CTCF topology classification. [PDF]

NAR Genom Bioinform, 2022
Galan S, Serra F, Marti-Renom MA.
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

GraphLooper: predicting chromatin loops based on hierarchical multi-view graph pooling method. [PDF]

Brief Bioinform
Wang S, Li Z, Feng H, Cui Z, Guo ZH, Liao Q, Hu Z, Liu W, Zhang Q, Huang DS.   +9 more
europepmc   +1 more source

Current Challenges of Transcription Compartmentalization Research

Advanced Science, EarlyView.
Transcription factors, coactivators, and RNA polymerase II assemble into transcription compartments ranging from small, defined complexes to liquid‐like condensates. This review unifies these seemingly competing descriptions along a single continuum and asks what these compartments have been shown to do, and what they have not, revealing that the most ...
Thomas Quail, Sina Wittmann
wiley   +1 more source

Cis-regulatory chromatin loops analysis identifies GRHL3 as a master regulator of surface epithelium commitment. [PDF]

Sci Adv, 2022
Huang H, Liu J, Li M, Guo H, Zhu J, Zhu L, Wu S, Mo K, Huang Y, Tan J, Chen C, Wang B, Yu Y, Wang L, Liu Y, Ouyang H.   +15 more
europepmc   +1 more source

Adaptive Responses of Tropical Crops: A Multi‐Scale Omics Integrated Perspective

Advanced Science, EarlyView.
Tropical crops integrate genomic, morphological, physiological, and ecological adaptations to thrive under extreme and variable environments. This review highlights how natural selection, domestication, and breeding shape stress resilience, resource‐use strategies, and productivity in sugarcane, banana, cassava, rubber and oil palm, offering new routes
Peilin Wang, Chenhui Li, Dongjiao Wang, Qibin Wu, Zhen Zeng, Huiming Guo, Han Cheng, Songbi Chen, Hongxing Cao, Hongmei Cheng, Jianghui Xie, Youxiong Que   +11 more
wiley   +1 more source

Engineering chromatin loops to control cell fate: LoopID reveals catalytic-independent functions of epigenetic regulators. [PDF]

Cell Transplant
Li H, Silva JCR.
europepmc   +1 more source

8-oxodG accumulation within super-enhancers marks fragile CTCF-mediated chromatin loops. [PDF]

Nucleic Acids Res, 2022
Scala G, Gorini F, Ambrosio S, Chiariello AM, Nicodemi M, Lania L, Majello B, Amente S.   +7 more
europepmc   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

A split luciferase biosensing platform for detection and imaging of chromatin loops in individual live cells. [PDF]

Nucleic Acids Res
Heath NG, Gomez JA, McGinty SP, O'Geen H, Segal DJ.   +4 more
europepmc   +1 more source