Results 181 to 190 of about 329,145 (275)

Characterization of Protein Co-Localization and Histone Modifications at Enhancers Anchored in Chromatin Loops. [PDF]

Biology (Basel)
Sheng W, Nie Y.
europepmc   +1 more source

CCIP: predicting CTCF-mediated chromatin loops with transitivity. [PDF]

Bioinformatics, 2021
Wang W, Gao L, Ye Y, Gao Y.
europepmc   +1 more source

DyProL: Dynamic Ensemble Representation Learning for Protein–Nucleic Acid Binding Site Prediction

Advanced Science, EarlyView.
Protein function is represented as a dynamic conformational ensemble rather than a single static structure. A multi‐conformation geometric attention framework aligns, clusters, and learns representative states to capture residue‐ and ensemble‐level signals. Integrating structural dynamics improves interpretable protein‐NA binding prediction and reveals
Pengpai Li, Yiman Liu, Liya Liang, Rongming Liu   +3 more
wiley   +1 more source

3D genome organization in tissue regeneration involves long-range chromatin loops. [PDF]

Sci Adv
Llorens-Giralt P, Camilleri-Robles C, Zuber L, Khadka J, Marti-Marimon M, Crespo-Pera A, Serras F, Gambetta MC, Marti-Renom MA, Corominas M.   +9 more
europepmc   +1 more source

Integrating extrusion complex-associated pattern to predict cell type-specific long-range chromatin loops. [PDF]

iScience, 2022
Deng Y, Tang L, Zhou X, Wang W, Li M.
europepmc   +1 more source

Single‐Molecule Imaging of Endogenous RNA Using a Miniaturized and Circularly Permuted CRISPR‐Cas13 Degron‐Masking System CDegSR

Advanced Science, EarlyView.
CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Lineage-specific rearrangement of chromatin loops and epigenomic features during adipocytes and osteoblasts commitment. [PDF]

Cell Death Differ, 2022
Hao RH, Guo Y, Wang C, Chen F, Di CX, Dong SS, Cao QL, Guo J, Rong Y, Yao S, Zhu DL, Chen YX, Chen H, Yang TL.   +13 more
europepmc   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

GraphLooper: predicting chromatin loops based on hierarchical multi-view graph pooling method. [PDF]

Brief Bioinform
Wang S, Li Z, Feng H, Cui Z, Guo ZH, Liao Q, Hu Z, Liu W, Zhang Q, Huang DS.   +9 more
europepmc   +1 more source